FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2515362935> ?p ?o ?g. }

• W2515362935 endingPage "617" @default.
• W2515362935 startingPage "606" @default.
• W2515362935 abstract "Partial nephrectomy (PN) is the reference standard of management for a cT1a renal mass. However, its role in the management of larger tumors (cT1b and cT2) is still under scrutiny.To conduct a meta-analysis assessing functional, oncologic, and perioperative outcomes of PN and radical nephrectomy (RN) in the specific case of larger renal tumors (≥cT1b). The primary endpoint was an overall analysis of cT1b and cT2 masses. The secondary endpoint was a sensitivity analysis for cT2 only.A systematic literature review was performed up to December 2015 using multiple search engines to identify eligible comparative studies. A formal meta-analysis was performed for studies comparing PN to RN for both cT1b and cT2 tumors. In addition, a sensitivity analysis including the subgroup of studies comparing PN to RN for cT2 only was conducted. Pooled estimates were calculated using a fixed-effects model if no significant heterogeneity was identified; alternatively, a random-effects model was used when significant heterogeneity was detected. For continuous outcomes, the weighted mean difference (WMD) was used as summary measure. For binary variables, the odds ratio (OR) or risk ratio (RR) was calculated with 95% confidence interval (CI). Statistical analyses were performed using Review Manager 5 (Cochrane Collaboration, Oxford, UK).Overall, 21 case-control studies including 11204 patients (RN 8620; PN 2584) were deemed eligible and included in the analysis. Patients undergoing PN were younger (WMD -2.3 yr; p<0.001) and had smaller masses (WMD -0.65cm; p<0.001). Lower estimated blood loss was found for RN (WMD 102.6ml; p<0.001). There was a higher likelihood of postoperative complications for PN (RR 1.74, 95% CI 1.34-2.2; p<0.001). Pathology revealed a higher rate of malignant histology for the RN group (RR 0.97; p=0.02). PN was associated with better postoperative renal function, as shown by higher postoperative estimated glomerular filtration rate (eGFR; WMD 12.4ml/min; p<0.001), lower likelihood of postoperative onset of chronic kidney disease (RR 0.36; p<0.001), and lower decline in eGFR (WMD -8.6ml/min; p<0.001). The PN group had a lower likelihood of tumor recurrence (OR 0.6; p<0.001), cancer-specific mortality (OR 0.58; p=0.001), and all-cause mortality (OR 0.67; p=0.005). Four studies compared PN (n=212) to RN (n=1792) in the specific case of T2 tumors (>7cm). In this subset of patients, the estimated blood loss was higher for PN (WMD 107.6ml; p<0.001), as was the likelihood of complications (RR 2.0; p<0.001). Both the recurrence rate (RR 0.61; p=0.004) and cancer-specific mortality (RR 0.65; p=0.03) were lower for PN.PN is a viable treatment option for larger renal tumors, as it offers acceptable surgical morbidity, equivalent cancer control, and better preservation of renal function, with potential for better long-term survival. For T2 tumors, PN use should be more selective, and specific patient and tumor factors should be considered. Further investigation, ideally in a prospective randomized fashion, is warranted to better define the role of PN in this challenging clinical scenario.We performed a cumulative analysis of the literature to determine the best treatment option in cases of localized kidney tumor of higher clinical stage (T1b and T2, as based on preoperative imaging). Our findings suggest that removing only the tumor and saving the kidney might be an effective treatment modality in terms of cancer control, with the advantage of preserving the kidney function. However, a higher risk of perioperative complications should be taken into account when facing larger tumors (clinical stage T2) with kidney-sparing surgery." @default.
• W2515362935 created "2016-09-16" @default.
• W2515362935 creator A5013888713 @default.
• W2515362935 creator A5015528444 @default.
• W2515362935 creator A5028580518 @default.
• W2515362935 creator A5032156511 @default.
• W2515362935 creator A5050834286 @default.
• W2515362935 creator A5091807397 @default.
• W2515362935 date "2017-04-01" @default.
• W2515362935 modified "2023-10-17" @default.
• W2515362935 title "Partial Nephrectomy Versus Radical Nephrectomy for Clinical T1b and T2 Renal Tumors: A Systematic Review and Meta-analysis of Comparative Studies" @default.
• W2515362935 cites W1499681906 @default.
• W2515362935 cites W1537972189 @default.
• W2515362935 cites W1566691583 @default.
• W2515362935 cites W1568762723 @default.
• W2515362935 cites W1607603615 @default.
• W2515362935 cites W1883990073 @default.
• W2515362935 cites W1904470192 @default.
• W2515362935 cites W1918853894 @default.
• W2515362935 cites W1944020713 @default.
• W2515362935 cites W1969757544 @default.
• W2515362935 cites W1972835830 @default.
• W2515362935 cites W1974201878 @default.
• W2515362935 cites W1978281887 @default.
• W2515362935 cites W1981972946 @default.
• W2515362935 cites W1984772825 @default.
• W2515362935 cites W1989246227 @default.
• W2515362935 cites W1991234265 @default.
• W2515362935 cites W1992882990 @default.
• W2515362935 cites W1993844148 @default.
• W2515362935 cites W1994604939 @default.
• W2515362935 cites W1998940579 @default.
• W2515362935 cites W2000785370 @default.
• W2515362935 cites W2001469462 @default.
• W2515362935 cites W2004650249 @default.
• W2515362935 cites W2006610247 @default.
• W2515362935 cites W2007991740 @default.
• W2515362935 cites W2009716110 @default.
• W2515362935 cites W2009997966 @default.
• W2515362935 cites W2012937637 @default.
• W2515362935 cites W2019192689 @default.
• W2515362935 cites W2023574066 @default.
• W2515362935 cites W2031087535 @default.
• W2515362935 cites W2031498413 @default.
• W2515362935 cites W2032692428 @default.
• W2515362935 cites W2041765997 @default.
• W2515362935 cites W2050836049 @default.
• W2515362935 cites W2058646774 @default.
• W2515362935 cites W2064072638 @default.
• W2515362935 cites W2080047068 @default.
• W2515362935 cites W2086105135 @default.
• W2515362935 cites W2086431532 @default.
• W2515362935 cites W2097975386 @default.
• W2515362935 cites W2107640783 @default.
• W2515362935 cites W2114465293 @default.
• W2515362935 cites W2115303260 @default.
• W2515362935 cites W2123344349 @default.
• W2515362935 cites W2125200750 @default.
• W2515362935 cites W2128922938 @default.
• W2515362935 cites W2141036520 @default.
• W2515362935 cites W2145632027 @default.
• W2515362935 cites W2156069570 @default.
• W2515362935 cites W2164317031 @default.
• W2515362935 cites W2167545922 @default.
• W2515362935 cites W2170912946 @default.
• W2515362935 cites W2171657748 @default.
• W2515362935 cites W2332861055 @default.
• W2515362935 cites W4238261079 @default.
• W2515362935 cites W4245722877 @default.
• W2515362935 cites W4245766263 @default.
• W2515362935 cites W4361744597 @default.
• W2515362935 doi "https://doi.org/10.1016/j.eururo.2016.08.060" @default.
• W2515362935 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27614693" @default.
• W2515362935 hasPublicationYear "2017" @default.
• W2515362935 type Work @default.
• W2515362935 sameAs 2515362935 @default.
• W2515362935 citedByCount "298" @default.
• W2515362935 countsByYear W25153629352017 @default.
• W2515362935 countsByYear W25153629352018 @default.
• W2515362935 countsByYear W25153629352019 @default.
• W2515362935 countsByYear W25153629352020 @default.
• W2515362935 countsByYear W25153629352021 @default.
• W2515362935 countsByYear W25153629352022 @default.
• W2515362935 countsByYear W25153629352023 @default.
• W2515362935 crossrefType "journal-article" @default.
• W2515362935 hasAuthorship W2515362935A5013888713 @default.
• W2515362935 hasAuthorship W2515362935A5015528444 @default.
• W2515362935 hasAuthorship W2515362935A5028580518 @default.
• W2515362935 hasAuthorship W2515362935A5032156511 @default.
• W2515362935 hasAuthorship W2515362935A5050834286 @default.
• W2515362935 hasAuthorship W2515362935A5091807397 @default.
• W2515362935 hasConcept C126322002 @default.
• W2515362935 hasConcept C126894567 @default.
• W2515362935 hasConcept C141071460 @default.
• W2515362935 hasConcept C156957248 @default.
• W2515362935 hasConcept C187960798 @default.
• W2515362935 hasConcept C2776478404 @default.
• W2515362935 hasConcept C2780091579 @default.

• next