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• W2515394998 abstract "Abstract Background Helicobacter pylori can cause many gastrointestinal and also extra‐gastrointestinal disorders and is a major risk factor for gastric carcinoma and MALT lymphoma. Currently, numerous antibiotic‐based therapies are available; however, these therapies have numerous drawbacks, mainly due to increasing prevalence of antibiotic resistant strains. Thus, there is an urgent need to develop novel therapeutic agents against H. pylori infections. Materials and Methods In this study, the anti‐ H. pylori activity of 2:1 mixture of Satureja hortensis and Origanum vulgare subsp. hirtum essential oils (2 MIX ) was investigated in vivo. After screening in vitro cytotoxicity of 2 MIX on mammalian cell lines, the therapeutic efficiency was studied in a mouse model, where changes in H. pylori colonization were detected by PCR and histology of gastric samples. The immune reaction of mice was tested based on cytokine and chemokine production, and the in vivo toxicity of 2 MIX was also investigated by measuring ALT and AST enzyme activities and Cyp3a11 and HO ‐1 mRNA levels in livers of mice. Results 2 MIX had not shown in vitro cytotoxicity against cell lines, only the highest concentration caused significant decrease in their survival rates. In the in vivo experiments, 2 MIX successfully eradicated the pathogen in 70% of the mice. We could not detect toxicity or altered cytokine and chemokine balance after in vivo treatments in mice. Conclusions These results show that 2 MIX is effective in reducing H. pylori colonization suggesting that this essential oil mixture has great potential as a new, effective, and safe therapeutic agent against H. pylori ." @default.
• W2515394998 created "2016-09-16" @default.
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• W2515394998 date "2016-08-31" @default.
• W2515394998 modified "2023-09-27" @default.
• W2515394998 title "Binary mixture of<i>Satureja hortensis</i>and<i>Origanum vulgare</i>subsp.<i>hirtum</i>essential oils: in vivo therapeutic efficiency against<i>Helicobacter pylori</i>infection" @default.
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• W2515394998 doi "https://doi.org/10.1111/hel.12350" @default.
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