Matches in SemOpenAlex for { <https://semopenalex.org/work/W2515471236> ?p ?o ?g. }
Showing items 1 to 70 of
70
with 100 items per page.
- W2515471236 endingPage "97" @default.
- W2515471236 startingPage "89" @default.
- W2515471236 abstract "Aneuploidy can have significant impact upon human health including reproductive problems and cancer. However, there is no test method currently that is widely used in routine screening assay for aneuploidy detection. In this study, in order to develop a routinely available screening assay, we evaluated the efficacy of our in vitro micronucleus (MN) test protocol. The MN test with a Chinese hamster lung cell line (CHL/IU) without cytochalasin B was conducted on seven chemicals, namely, five potential aneugens which induced polyploidy in the in vitro chromosomal aberration (CA) test and whose mechanism of action is unknown, and two well-known aneugens (colcemid and diethylstilbestrol). Besides micronucleated (MN) cells (parameter widely used for detecting clastogens and aneugens in the existing protocols), polynuclear (PN) cells and mitotic (M) cells were used for assessment of aneuploidy induction. In vitro CA tests were also performed to compare with the MN test. All seven chemicals induced polyploidy in the CA tests. While three chemicals significantly increased the frequency of MN, PN, and M cells in the MN tests, the other four chemicals increased only the frequency of PN cells. Based on the patterns of appearance of aberrant cells induced by test chemicals, the seven chemicals could be classified into two groups. It is thought that the difference in the patterns between the two groups reflects the difference in mechanisms of action. Our results indicate a possibility that aneuploidy and polyploidy can be distinguished by the analysis of patterns of appearance of aberrant cells in the MN test. We have concluded that our MN test protocol, easier-to-perform, and more sensitive for detecting potential aneugens as compared with the existing protocols, may be useful for routine screening." @default.
- W2515471236 created "2016-09-16" @default.
- W2515471236 creator A5012131904 @default.
- W2515471236 creator A5061012694 @default.
- W2515471236 creator A5075563895 @default.
- W2515471236 creator A5091137468 @default.
- W2515471236 date "2004-01-01" @default.
- W2515471236 modified "2023-09-24" @default.
- W2515471236 cites W1543721731 @default.
- W2515471236 cites W1967331918 @default.
- W2515471236 cites W1975404908 @default.
- W2515471236 cites W1976199579 @default.
- W2515471236 cites W1982566878 @default.
- W2515471236 cites W2005815786 @default.
- W2515471236 cites W2012077724 @default.
- W2515471236 cites W2016571415 @default.
- W2515471236 cites W2026958285 @default.
- W2515471236 cites W2027355586 @default.
- W2515471236 cites W2042667650 @default.
- W2515471236 cites W2048178689 @default.
- W2515471236 cites W2052825715 @default.
- W2515471236 cites W2059613902 @default.
- W2515471236 cites W2069170671 @default.
- W2515471236 cites W2088985983 @default.
- W2515471236 cites W2091356669 @default.
- W2515471236 cites W2105353553 @default.
- W2515471236 cites W2112560233 @default.
- W2515471236 cites W2116056093 @default.
- W2515471236 cites W2126137097 @default.
- W2515471236 cites W2127279305 @default.
- W2515471236 cites W2131036127 @default.
- W2515471236 cites W2137497507 @default.
- W2515471236 cites W2151613197 @default.
- W2515471236 cites W2154771600 @default.
- W2515471236 cites W2328016176 @default.
- W2515471236 cites W2399616656 @default.
- W2515471236 doi "https://doi.org/10.3123/jems.26.89" @default.
- W2515471236 hasPublicationYear "2004" @default.
- W2515471236 type Work @default.
- W2515471236 sameAs 2515471236 @default.
- W2515471236 citedByCount "1" @default.
- W2515471236 crossrefType "journal-article" @default.
- W2515471236 hasAuthorship W2515471236A5012131904 @default.
- W2515471236 hasAuthorship W2515471236A5061012694 @default.
- W2515471236 hasAuthorship W2515471236A5075563895 @default.
- W2515471236 hasAuthorship W2515471236A5091137468 @default.
- W2515471236 hasBestOaLocation W25154712361 @default.
- W2515471236 hasConcept C15744967 @default.
- W2515471236 hasConceptScore W2515471236C15744967 @default.
- W2515471236 hasIssue "2" @default.
- W2515471236 hasLocation W25154712361 @default.
- W2515471236 hasOpenAccess W2515471236 @default.
- W2515471236 hasPrimaryLocation W25154712361 @default.
- W2515471236 hasRelatedWork W1710126152 @default.
- W2515471236 hasRelatedWork W2053487507 @default.
- W2515471236 hasRelatedWork W2077865380 @default.
- W2515471236 hasRelatedWork W2134894512 @default.
- W2515471236 hasRelatedWork W2138503431 @default.
- W2515471236 hasRelatedWork W2748952813 @default.
- W2515471236 hasRelatedWork W2765597752 @default.
- W2515471236 hasRelatedWork W2899084033 @default.
- W2515471236 hasRelatedWork W2931662336 @default.
- W2515471236 hasRelatedWork W3049356719 @default.
- W2515471236 hasVolume "26" @default.
- W2515471236 isParatext "false" @default.
- W2515471236 isRetracted "false" @default.
- W2515471236 magId "2515471236" @default.
- W2515471236 workType "article" @default.