FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2515547223> ?p ?o ?g. }

• W2515547223 endingPage "2312" @default.
• W2515547223 startingPage "2301" @default.
• W2515547223 abstract "Human and animal studies have identified an especially critical role for the brainstem parabrachial (PB) complex in regulating electrocortical (electroencephalogram [EEG]) and behavioral arousal: lesions of the PB complex produce a monotonous high-voltage, slow-wave EEG and eliminate spontaneous behaviors. We report here that targeted chemogenetic activation of the PB complex produces sustained EEG and behavioral arousal in the rat. We further establish, using viral-mediated retrograde activation, that PB projections to the preoptic-basal forebrain and lateral hypothalamus, but not to the thalamus, mediate PB-driven wakefulness. We exploited this novel and noninvasive model of induced wakefulness to explore the EEG and metabolic consequences of extended wakefulness. Repeated (daily) chemogenetic activation of the PB was highly effective in extending wakefulness over 4 days, although subsequent PB activation produced progressively lesser wake amounts. Curiously, no EEG or behavioral sleep rebound was observed, even after 4 days of induced wakefulness. Following the last of the four daily induced wake bouts, we examined the brains and observed a chimeric pattern of c-Fos expression, with c-Fos expressed in subsets of both arousal- and sleep-promoting nuclei. From a metabolic standpoint, induced extended wakefulness significantly reduced body weight and leptin but was without significant effect on cholesterol, triglyceride, or insulin levels, suggesting that high sleep pressure or sleep debt per se does not, as previously implicated, result in a deleterious metabolic phenotype." @default.
• W2515547223 created "2016-09-16" @default.
• W2515547223 creator A5017630892 @default.
• W2515547223 creator A5050298481 @default.
• W2515547223 creator A5055163801 @default.
• W2515547223 creator A5073872497 @default.
• W2515547223 date "2016-09-01" @default.
• W2515547223 modified "2023-10-15" @default.
• W2515547223 title "Stimulation of the Pontine Parabrachial Nucleus Promotes Wakefulness via Extra-thalamic Forebrain Circuit Nodes" @default.
• W2515547223 cites W1526357021 @default.
• W2515547223 cites W1965164490 @default.
• W2515547223 cites W1967534613 @default.
• W2515547223 cites W1971355925 @default.
• W2515547223 cites W1973614121 @default.
• W2515547223 cites W1978920053 @default.
• W2515547223 cites W1980603718 @default.
• W2515547223 cites W1985681303 @default.
• W2515547223 cites W1992138108 @default.
• W2515547223 cites W1998722012 @default.
• W2515547223 cites W1999080748 @default.
• W2515547223 cites W2000140223 @default.
• W2515547223 cites W2002338746 @default.
• W2515547223 cites W2009354967 @default.
• W2515547223 cites W2020694953 @default.
• W2515547223 cites W2022979342 @default.
• W2515547223 cites W2029035945 @default.
• W2515547223 cites W2029048820 @default.
• W2515547223 cites W2031635252 @default.
• W2515547223 cites W2038008568 @default.
• W2515547223 cites W2038429516 @default.
• W2515547223 cites W2039672492 @default.
• W2515547223 cites W2040991910 @default.
• W2515547223 cites W2045226019 @default.
• W2515547223 cites W2054281595 @default.
• W2515547223 cites W2059226449 @default.
• W2515547223 cites W2063210874 @default.
• W2515547223 cites W2065835848 @default.
• W2515547223 cites W2070373962 @default.
• W2515547223 cites W2102884007 @default.
• W2515547223 cites W2107100408 @default.
• W2515547223 cites W2113836851 @default.
• W2515547223 cites W2115070641 @default.
• W2515547223 cites W2115361864 @default.
• W2515547223 cites W2132320914 @default.
• W2515547223 cites W2145501808 @default.
• W2515547223 cites W2151102772 @default.
• W2515547223 cites W2152527426 @default.
• W2515547223 cites W2154037423 @default.
• W2515547223 cites W2159953069 @default.
• W2515547223 cites W2161241864 @default.
• W2515547223 cites W2185009682 @default.
• W2515547223 cites W2359465695 @default.
• W2515547223 cites W2409837131 @default.
• W2515547223 cites W62951107 @default.
• W2515547223 cites W84689042 @default.
• W2515547223 doi "https://doi.org/10.1016/j.cub.2016.07.054" @default.
• W2515547223 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5025760" @default.
• W2515547223 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27546576" @default.
• W2515547223 hasPublicationYear "2016" @default.
• W2515547223 type Work @default.
• W2515547223 sameAs 2515547223 @default.
• W2515547223 citedByCount "69" @default.
• W2515547223 countsByYear W25155472232016 @default.
• W2515547223 countsByYear W25155472232017 @default.
• W2515547223 countsByYear W25155472232018 @default.
• W2515547223 countsByYear W25155472232019 @default.
• W2515547223 countsByYear W25155472232020 @default.
• W2515547223 countsByYear W25155472232021 @default.
• W2515547223 countsByYear W25155472232022 @default.
• W2515547223 countsByYear W25155472232023 @default.
• W2515547223 crossrefType "journal-article" @default.
• W2515547223 hasAuthorship W2515547223A5017630892 @default.
• W2515547223 hasAuthorship W2515547223A5050298481 @default.
• W2515547223 hasAuthorship W2515547223A5055163801 @default.
• W2515547223 hasAuthorship W2515547223A5073872497 @default.
• W2515547223 hasBestOaLocation W25155472231 @default.
• W2515547223 hasConcept C126322002 @default.
• W2515547223 hasConcept C134018914 @default.
• W2515547223 hasConcept C169760540 @default.
• W2515547223 hasConcept C2776287375 @default.
• W2515547223 hasConcept C2777003273 @default.
• W2515547223 hasConcept C2777820223 @default.
• W2515547223 hasConcept C2779246727 @default.
• W2515547223 hasConcept C2779320081 @default.
• W2515547223 hasConcept C2779715522 @default.
• W2515547223 hasConcept C2780714764 @default.
• W2515547223 hasConcept C2910823151 @default.
• W2515547223 hasConcept C36951298 @default.
• W2515547223 hasConcept C522805319 @default.
• W2515547223 hasConcept C529278444 @default.
• W2515547223 hasConcept C551621295 @default.
• W2515547223 hasConcept C71924100 @default.
• W2515547223 hasConcept C86803240 @default.
• W2515547223 hasConceptScore W2515547223C126322002 @default.
• W2515547223 hasConceptScore W2515547223C134018914 @default.
• W2515547223 hasConceptScore W2515547223C169760540 @default.
• W2515547223 hasConceptScore W2515547223C2776287375 @default.
• W2515547223 hasConceptScore W2515547223C2777003273 @default.

• next