FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2515669969> ?p ?o ?g. }

• W2515669969 endingPage "471" @default.
• W2515669969 startingPage "456" @default.
• W2515669969 abstract "Autism spectrum disorder (ASD) is a prevalent and heterogeneous neurodevelopmental disorder characterized by hallmark behavioral features. The spectrum of disorders that fall within the ASD umbrella encompass a distinct but overlapping symptom complex that likely results from an array of molecular and genetic aberrations rather than a single genetic mutation. The ketogenic diet (KD) is a high-fat low-carbohydrate anti-seizure and neuroprotective diet that has demonstrated efficacy in the treatment of ASD-like behaviors in animal and human studies.We investigated changes in mRNA and gene expression in the BTBR mouse model of ASD that may contribute to the behavioral phenotype. In addition, we sought to examine changes in gene expression following KD treatment in BTBR mice.Despite significant behavioral abnormalities, expression changes in BTBR mice did not differ substantially from controls; only 33 genes were differentially expressed in the temporal cortex, and 48 in the hippocampus. Examination of these differentially expressed genes suggested deficits in the stress response and in neuronal signaling/communication. After treatment with the KD, both brain regions demonstrated improvements in ASD deficits associated with myelin formation and white matter development.Although our study supports many of the previously known impairments associated with ASD, such as excessive myelin formation and impaired GABAergic transmission, the RNAseq data and pathway analysis utilized here identified new therapeutic targets for analysis, such as Vitamin D pathways and cAMP signaling. Autism Res 2017, 10: 456-471. © 2016 International Society for Autism Research, Wiley Periodicals, Inc." @default.
• W2515669969 created "2016-09-16" @default.
• W2515669969 creator A5010085174 @default.
• W2515669969 creator A5059300979 @default.
• W2515669969 date "2016-08-16" @default.
• W2515669969 modified "2023-10-18" @default.
• W2515669969 title "Genetic modifications associated with ketogenic diet treatment in the BTBR^T+Tf/Jmouse model of autism spectrum disorder" @default.
• W2515669969 cites W1172792186 @default.
• W2515669969 cites W1562466038 @default.
• W2515669969 cites W1572146622 @default.
• W2515669969 cites W1964262871 @default.
• W2515669969 cites W1966556786 @default.
• W2515669969 cites W1978992015 @default.
• W2515669969 cites W1985559859 @default.
• W2515669969 cites W1986863562 @default.
• W2515669969 cites W1989812280 @default.
• W2515669969 cites W1995289028 @default.
• W2515669969 cites W1996441448 @default.
• W2515669969 cites W1998944144 @default.
• W2515669969 cites W2002012536 @default.
• W2515669969 cites W2004413954 @default.
• W2515669969 cites W2013859310 @default.
• W2515669969 cites W2014619876 @default.
• W2515669969 cites W2014814414 @default.
• W2515669969 cites W2030602458 @default.
• W2515669969 cites W2032693719 @default.
• W2515669969 cites W2033815458 @default.
• W2515669969 cites W2035027696 @default.
• W2515669969 cites W2037380656 @default.
• W2515669969 cites W2045313390 @default.
• W2515669969 cites W2050550932 @default.
• W2515669969 cites W2053590636 @default.
• W2515669969 cites W2053702156 @default.
• W2515669969 cites W2062447656 @default.
• W2515669969 cites W2067213832 @default.
• W2515669969 cites W2068513712 @default.
• W2515669969 cites W2071797996 @default.
• W2515669969 cites W2074457840 @default.
• W2515669969 cites W2075364461 @default.
• W2515669969 cites W2082023836 @default.
• W2515669969 cites W2082548421 @default.
• W2515669969 cites W2085377666 @default.
• W2515669969 cites W2086576625 @default.
• W2515669969 cites W2089139236 @default.
• W2515669969 cites W2090153386 @default.
• W2515669969 cites W2093418477 @default.
• W2515669969 cites W2095602246 @default.
• W2515669969 cites W2096358139 @default.
• W2515669969 cites W2098277878 @default.
• W2515669969 cites W2099440139 @default.
• W2515669969 cites W2100972564 @default.
• W2515669969 cites W2103441770 @default.
• W2515669969 cites W2105293542 @default.
• W2515669969 cites W2110065044 @default.
• W2515669969 cites W2111499866 @default.
• W2515669969 cites W2112144930 @default.
• W2515669969 cites W2112805830 @default.
• W2515669969 cites W2116449899 @default.
• W2515669969 cites W2118550312 @default.
• W2515669969 cites W2131545168 @default.
• W2515669969 cites W2136189765 @default.
• W2515669969 cites W2142037700 @default.
• W2515669969 cites W2152239989 @default.
• W2515669969 cites W2155347288 @default.
• W2515669969 cites W2160365682 @default.
• W2515669969 cites W2161450501 @default.
• W2515669969 cites W2163282756 @default.
• W2515669969 cites W2164808967 @default.
• W2515669969 cites W2167906737 @default.
• W2515669969 cites W2171804213 @default.
• W2515669969 cites W2291072263 @default.
• W2515669969 cites W4214953333 @default.
• W2515669969 cites W4247665917 @default.
• W2515669969 doi "https://doi.org/10.1002/aur.1682" @default.
• W2515669969 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27529337" @default.
• W2515669969 hasPublicationYear "2016" @default.
• W2515669969 type Work @default.
• W2515669969 sameAs 2515669969 @default.
• W2515669969 citedByCount "36" @default.
• W2515669969 countsByYear W25156699692017 @default.
• W2515669969 countsByYear W25156699692018 @default.
• W2515669969 countsByYear W25156699692019 @default.
• W2515669969 countsByYear W25156699692020 @default.
• W2515669969 countsByYear W25156699692021 @default.
• W2515669969 countsByYear W25156699692022 @default.
• W2515669969 countsByYear W25156699692023 @default.
• W2515669969 crossrefType "journal-article" @default.
• W2515669969 hasAuthorship W2515669969A5010085174 @default.
• W2515669969 hasAuthorship W2515669969A5059300979 @default.
• W2515669969 hasConcept C118552586 @default.
• W2515669969 hasConcept C15744967 @default.
• W2515669969 hasConcept C169760540 @default.
• W2515669969 hasConcept C205778803 @default.
• W2515669969 hasConcept C2778186239 @default.
• W2515669969 hasConcept C2778538070 @default.
• W2515669969 hasConcept C2778587478 @default.
• W2515669969 hasConcept C2779388368 @default.
• W2515669969 hasConcept C2781161787 @default.

• next