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- W2515673729 abstract "Background: Ionizing radia�on irradiated from iodine-131 can induce DNA damage and cell death. The cellular DNA damage is the cause of muta�on and cancer. The micronucleus assay in polychroma�c erythrocytes was applied toassess the radio-protec�ve effect of Turmeric extract on genotoxic poten�al of iodine therapy. Materials and Methods: Thirty six male albino rats were randomly divided in six groups. A single dose (200 or 500 mg/kg) of Turmericextract was injected to the rats 30 min before iodine therapy. Iodine-131 (5.55 MBq) was administrated intra peritoneal to the experimental animals. The percentage of micronuclei in PCE, NCE and ra�o of PCE / (PCE + NCE) wasdetermined 48 h a6er iodine injec�on for each experimental group to assess iodine-131 radia�on effects with or without Turmeric extract. Results: Iodine therapy showed a significant increase in the number of micronucleus forma�on. The animals treated with different doses of Turmeric extract + iodine showed a significant reduc�on in the frequency of micronucleus compared to the animals treated with iodine-131 alone. Both doses of Turmeric extract had the same effect when injected 30 min prior to iodine therapy. Conclusion: Our results indicate protec�ve effect of Turmericextract against gene�c damages induced by iodine-131 administra�on.Keywords: Turmeric, iodine-131, micronucleus." @default.
- W2515673729 created "2016-09-16" @default.
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- W2515673729 date "2016-01-01" @default.
- W2515673729 modified "2023-09-26" @default.
- W2515673729 title "Turmeric extract decreased frequency of polychromatic erythrocytes micronuclei induced by iodine-131" @default.
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- W2515673729 doi "https://doi.org/10.18869/acadpub.ijrr.14.1.47" @default.
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