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- W2515678770 abstract "This study evaluated the efficacy, safety and impact on quality of life (QoL) of a dose-dense biweekly regimen of docetaxel and 5-fluorouracil in first-line treat- ment of advanced gastric cancer (AGC). Eligible patients received docetaxel 60 mg/m 2 and 5-fluorouracil (400 mg/ m 2 bolus followed by 2,400 mg/m 2 46-h infusion), fort- nightly. Prophylactic use of G-CSF was adopted in all patients. The primary end point was response rate (RR). Secondary end points were progression-free survival (PFS), overall survival (OS), toxicity and QoL. Thirty-nine patients with a median age of 55 (28-80) were included. The RR was 51.3 %. Median PFS and OS were 6.7 and 14.0 months, respectively. The most common adverse events (all grades) were anemia (34, 87.2 %), fatigue (29, 74.4 %), neutropenia (26, 66.7 %), nail change (19, 48.7 %) and liver dysfunction (15, 38.5 %). In QoL ana- lysis, improvements were obtained in seven scales, whereas drops were seen in three scales. Common Grade 3/4 tox- icities included anemia (28.2 %), liver dysfunction (7.7 %) and fatigue (7.7 %). This novel regimen is a promising option for AGC, showing high RR, improvement on QoL and acceptable toxicity." @default.
- W2515678770 created "2016-09-16" @default.
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- W2515678770 date "2015-01-01" @default.
- W2515678770 modified "2023-09-27" @default.
- W2515678770 title "Dose-dense biweekly docetaxel combined with 5-fluorouracil as first-line treatment in advanced gastric cancer: a phase II trial Jian XiaoYonghe ChenWenyun LiJiaying Gong • Zhiyang ZhouYanhong DengLei WangDonglin Ren •" @default.
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