FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2515690785> ?p ?o ?g. }

• W2515690785 endingPage "2647" @default.
• W2515690785 startingPage "2641" @default.
• W2515690785 abstract "Ki-67 is one of the most useful markers to evaluate cell proliferative activity and has been widely used in tumor treatment and research. However, its role in human laryngeal carcinoma remains poorly defined. The aim of the present study was to investigate the expression of Ki-67 in human laryngeal squamous carcinoma and the effect of Ki-67 gene silencing by small interfering (si)RNA on the proliferation of human laryngocarcinoma HEp2 cells. Immunohistochemistry and reverse transcription-quantitative polymerase chain reaction were performed to examine the expression of Ki-67 in human laryngeal squamous carcinoma tissues and adjacent non-cancer tissues from 50 patients with laryngeal squamous carcinoma. RNA interference was used to knock down the expression of Ki-67 in the HEp2 cell line, and the proliferation of the treated cells was observed in vitro. Western blot analysis was used to determine the expression levels of epidermal growth factor receptor (EGFR) and E-cadherin in the treated cells. The expression of Ki-67 in the laryngeal squamous carcinoma tissues was significantly higher than that of the adjacent non-tumor tissues (P=0.028). The high expression of Ki-67 in cancer was significantly correlated with cervical lymph node metastasis and clinical outcomes (all P<0.001). The silencing of Ki-67 resulted in the inhibition of proliferation of the HEp2 human laryngocarcinoma cells (P<0.001). In addition, compared with the control group, the expression levels of EGFR and E-cadherin in the Ki-67 siRNA-treated cells were significantly decreased (P<0.001) and increased (P<0.001), respectively. These results suggested that Ki-67 is important in regulating the proliferation of human laryngocarcinoma HEp2 cells and that the mechanism may at least partially be associated with the upregulation of EGFR and the downregulation of E-cadherin. Overall, Ki-67 can be used as an important indicator for judging clinical progress and estimating prognosis in human laryngeal squamous carcinoma." @default.
• W2515690785 created "2016-09-16" @default.
• W2515690785 creator A5002163860 @default.
• W2515690785 creator A5027220635 @default.
• W2515690785 creator A5035833814 @default.
• W2515690785 creator A5078578035 @default.
• W2515690785 creator A5082818660 @default.
• W2515690785 creator A5086058158 @default.
• W2515690785 date "2016-08-08" @default.
• W2515690785 modified "2023-10-16" @default.
• W2515690785 title "Ki-67 is overexpressed in human laryngeal carcinoma and contributes to the proliferation of HEp2 cells" @default.
• W2515690785 cites W146902904 @default.
• W2515690785 cites W1489118867 @default.
• W2515690785 cites W1974880343 @default.
• W2515690785 cites W1976454566 @default.
• W2515690785 cites W1983356414 @default.
• W2515690785 cites W1985213644 @default.
• W2515690785 cites W1996639057 @default.
• W2515690785 cites W2007649418 @default.
• W2515690785 cites W2015628580 @default.
• W2515690785 cites W2019114472 @default.
• W2515690785 cites W2038047082 @default.
• W2515690785 cites W2042965279 @default.
• W2515690785 cites W2047781274 @default.
• W2515690785 cites W2062100928 @default.
• W2515690785 cites W2068989532 @default.
• W2515690785 cites W2093977679 @default.
• W2515690785 cites W2103564356 @default.
• W2515690785 cites W2103706721 @default.
• W2515690785 cites W2114570899 @default.
• W2515690785 cites W2134171958 @default.
• W2515690785 cites W2148154878 @default.
• W2515690785 cites W2166946831 @default.
• W2515690785 cites W2187601106 @default.
• W2515690785 cites W2375262385 @default.
• W2515690785 cites W2397854728 @default.
• W2515690785 cites W2398296636 @default.
• W2515690785 cites W2414901963 @default.
• W2515690785 cites W2416217862 @default.
• W2515690785 cites W2437941778 @default.
• W2515690785 cites W2597872842 @default.
• W2515690785 cites W2105700721 @default.
• W2515690785 doi "https://doi.org/10.3892/ol.2016.4980" @default.
• W2515690785 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5038896" @default.
• W2515690785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27703526" @default.
• W2515690785 hasPublicationYear "2016" @default.
• W2515690785 type Work @default.
• W2515690785 sameAs 2515690785 @default.
• W2515690785 citedByCount "10" @default.
• W2515690785 countsByYear W25156907852017 @default.
• W2515690785 countsByYear W25156907852018 @default.
• W2515690785 countsByYear W25156907852019 @default.
• W2515690785 countsByYear W25156907852020 @default.
• W2515690785 countsByYear W25156907852021 @default.
• W2515690785 crossrefType "journal-article" @default.
• W2515690785 hasAuthorship W2515690785A5002163860 @default.
• W2515690785 hasAuthorship W2515690785A5027220635 @default.
• W2515690785 hasAuthorship W2515690785A5035833814 @default.
• W2515690785 hasAuthorship W2515690785A5078578035 @default.
• W2515690785 hasAuthorship W2515690785A5082818660 @default.
• W2515690785 hasAuthorship W2515690785A5086058158 @default.
• W2515690785 hasBestOaLocation W25156907851 @default.
• W2515690785 hasConcept C104317684 @default.
• W2515690785 hasConcept C119056186 @default.
• W2515690785 hasConcept C121608353 @default.
• W2515690785 hasConcept C142724271 @default.
• W2515690785 hasConcept C1491633281 @default.
• W2515690785 hasConcept C166703698 @default.
• W2515690785 hasConcept C204232928 @default.
• W2515690785 hasConcept C22615655 @default.
• W2515690785 hasConcept C2777546739 @default.
• W2515690785 hasConcept C2777751288 @default.
• W2515690785 hasConcept C2781018059 @default.
• W2515690785 hasConcept C29537977 @default.
• W2515690785 hasConcept C47170353 @default.
• W2515690785 hasConcept C502942594 @default.
• W2515690785 hasConcept C54009773 @default.
• W2515690785 hasConcept C54355233 @default.
• W2515690785 hasConcept C55493867 @default.
• W2515690785 hasConcept C62112901 @default.
• W2515690785 hasConcept C67705224 @default.
• W2515690785 hasConcept C71924100 @default.
• W2515690785 hasConcept C81885089 @default.
• W2515690785 hasConcept C86803240 @default.
• W2515690785 hasConceptScore W2515690785C104317684 @default.
• W2515690785 hasConceptScore W2515690785C119056186 @default.
• W2515690785 hasConceptScore W2515690785C121608353 @default.
• W2515690785 hasConceptScore W2515690785C142724271 @default.
• W2515690785 hasConceptScore W2515690785C1491633281 @default.
• W2515690785 hasConceptScore W2515690785C166703698 @default.
• W2515690785 hasConceptScore W2515690785C204232928 @default.
• W2515690785 hasConceptScore W2515690785C22615655 @default.
• W2515690785 hasConceptScore W2515690785C2777546739 @default.
• W2515690785 hasConceptScore W2515690785C2777751288 @default.
• W2515690785 hasConceptScore W2515690785C2781018059 @default.
• W2515690785 hasConceptScore W2515690785C29537977 @default.
• W2515690785 hasConceptScore W2515690785C47170353 @default.
• W2515690785 hasConceptScore W2515690785C502942594 @default.

• next