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- W2515691045 abstract "Marek’s disease virus (MDV), a highly cell-associated lymphotropic α-herpesvirus, is the causative agent of Marek’s disease (MD) in domestic chickens. MDV replicates in chicken lymphocytes and establishes a latent infection within CD4+ T cells. The latently infected CD4+ T cells carry the virus to visceral organs, peripheral nerves, and feather follicle epithelium (FFE). FFE is the only anatomical site where infectious enveloped cell-free virus particles are produced and disseminated into the environment. This study investigated the immunological responses and mechanism of viral-induced immunosuppression and immune evasion in the FFE. Strong viral replication and lack of a significant number of cytotoxic T lymphocytes (CTL) in the infected tissues was prominent. Although the overall gene expression pattern was suggestive of a Th1 type immune response, the expression levels of several key immune genes were down regulated in the infected tissues. The mechanism of MDV-induced immunosuppression appears to be through inhibition of CTL function due to down regulation of CD8 glycoprotein and/or blocking of CTL migration due to decrease expression of cell adhesion molecules." @default.
- W2515691045 created "2016-09-16" @default.
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- W2515691045 date "2016-11-01" @default.
- W2515691045 modified "2023-10-17" @default.
- W2515691045 title "Marek’s disease virus immunosuppression alters host cellular responses and immune gene expression in the skin of infected chickens" @default.
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- W2515691045 doi "https://doi.org/10.1016/j.vetimm.2016.08.013" @default.
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