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- W2515694513 abstract "Oxidative stress induced by reactive oxygen species (ROS) plays an important role in the development of osteoporosis. Non-pharmacological measures, such as nutritional strategies that include antioxidant activities of food and vegetables, have been suggested to prevent age-related diseases. This study investigated whether nasunin, the major component of anthocyanin pigment of skin eggplant (Solanum melongena L), counteracts tert-butyl hydroperoxide (t-BHP)-induced oxidative damage in MC3T3-E1 osteoblastic cells. Pretreatment with purified nasunin (10-11 -10-5 M) increased viability and reduced apoptosis of MC3T3-E1 cells cultured with t-BHP (250 µM, 3h) and limited t-BHP induced reduction in osteoblast differentiation markers (alkaline phosphatase, collagen content). Furthermore, nasunin (10-9 M) prevented t-BHP-induced osteoblastic dysfunction and changes in the cytoskeleton organization due to both an increase of intracellular glutathione and a decrease of intracellular ROS. The nasunin-induced protective effects against t-BHP injury are mediated by the phosphoinositide 3-kinase (PI3K) /Akt signalling pathway since LY294002, a PI3K-specific inhibitor, worsened the cytotoxic effect of t-BHP and reversed the protective action of nasunin. Our results support nasunin as a possible valuable approach in the management of osteoblast dysfunction associated with oxidative stress, as occurs in osteoporosis." @default.
- W2515694513 created "2016-09-16" @default.
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- W2515694513 date "2016-05-04" @default.
- W2515694513 modified "2023-09-27" @default.
- W2515694513 title "NASUNIN, THE MAJOR COMPONENT OF ANTHOCYANIN PIGMENT OF EGGPLANT, PROTECTS CULTURED MC3T3-E1 OSTEOBLASTIC CELLS AGAINTS OXIDATIVE STRESS." @default.
- W2515694513 doi "https://doi.org/10.18143/jisanh_v3i3_1202" @default.
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