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• W251569704 abstract "While target potency and selectivity are important attributes to consider as candidate compounds are evaluated, there are other important properties that must be evaluated before a candidate compound can move into the realm of in vivo efficacy testing. The pharmacokinetic (PK) properties of the candidate must also be suitable for the desired physiological response. In vitro absorption, distribution, metabolism, excretion, and toxicology screening systems can provide an opportunity to predict performance in an in vivo setting. Compounds that meet the program's criteria for advancement can then be tested in an in vivo setting to determine their clearance, volume of distribution, half-life, bioavailability, and related PK parameters. This information can be used to facilitate the design of improved analogs and to set the dosing levels for animal efficacy studies. In the absence of suitable PK properties, a lead compound cannot progress beyond the in vitro stage of discovery." @default.
• W251569704 created "2016-06-24" @default.
• W251569704 creator A5048982391 @default.
• W251569704 date "2015-01-01" @default.
• W251569704 modified "2023-10-14" @default.
• W251569704 title "In vitro ADME and In vivo Pharmacokinetics" @default.
• W251569704 cites W128151115 @default.
• W251569704 cites W1498305210 @default.
• W251569704 cites W152943885 @default.
• W251569704 cites W1580142972 @default.
• W251569704 cites W1812532407 @default.
• W251569704 cites W1859096580 @default.
• W251569704 cites W1895187576 @default.
• W251569704 cites W1896494894 @default.
• W251569704 cites W1904678284 @default.
• W251569704 cites W1910056530 @default.
• W251569704 cites W1917367513 @default.
• W251569704 cites W1965129145 @default.
• W251569704 cites W1968324829 @default.
• W251569704 cites W1968817047 @default.
• W251569704 cites W1971901938 @default.
• W251569704 cites W1974290383 @default.
• W251569704 cites W1977003376 @default.
• W251569704 cites W1978245422 @default.
• W251569704 cites W1981299770 @default.
• W251569704 cites W1981871034 @default.
• W251569704 cites W1982077060 @default.
• W251569704 cites W1982604624 @default.
• W251569704 cites W1983332175 @default.
• W251569704 cites W1985108123 @default.
• W251569704 cites W1990129121 @default.
• W251569704 cites W1992364351 @default.
• W251569704 cites W1996161358 @default.
• W251569704 cites W1998337283 @default.
• W251569704 cites W2003512894 @default.
• W251569704 cites W2005753373 @default.
• W251569704 cites W2009938237 @default.
• W251569704 cites W2012315536 @default.
• W251569704 cites W2014685553 @default.
• W251569704 cites W2015159875 @default.
• W251569704 cites W2026976753 @default.
• W251569704 cites W2027217743 @default.
• W251569704 cites W2027549508 @default.
• W251569704 cites W2028360056 @default.
• W251569704 cites W2029007410 @default.
• W251569704 cites W2032865438 @default.
• W251569704 cites W2035560231 @default.
• W251569704 cites W2036682576 @default.
• W251569704 cites W2041755232 @default.
• W251569704 cites W2046826638 @default.
• W251569704 cites W2046827775 @default.
• W251569704 cites W2047186810 @default.
• W251569704 cites W2048541050 @default.
• W251569704 cites W2049684731 @default.
• W251569704 cites W2057041031 @default.
• W251569704 cites W2058557855 @default.
• W251569704 cites W2058663941 @default.
• W251569704 cites W2058953230 @default.
• W251569704 cites W2060087768 @default.
• W251569704 cites W2061650979 @default.
• W251569704 cites W2061657752 @default.
• W251569704 cites W2066790410 @default.
• W251569704 cites W2068154536 @default.
• W251569704 cites W2074332625 @default.
• W251569704 cites W2077162530 @default.
• W251569704 cites W2077984371 @default.
• W251569704 cites W2078486393 @default.
• W251569704 cites W2088444678 @default.
• W251569704 cites W2088788142 @default.
• W251569704 cites W2091699724 @default.
• W251569704 cites W2093020725 @default.
• W251569704 cites W2094855482 @default.
• W251569704 cites W2106941934 @default.
• W251569704 cites W2108675611 @default.
• W251569704 cites W2111937069 @default.
• W251569704 cites W2117753715 @default.
• W251569704 cites W2120586432 @default.
• W251569704 cites W2122010784 @default.
• W251569704 cites W2129863852 @default.
• W251569704 cites W2131803903 @default.
• W251569704 cites W2134906181 @default.
• W251569704 cites W2137037573 @default.
• W251569704 cites W2142024216 @default.
• W251569704 cites W2148820240 @default.
• W251569704 cites W2153450890 @default.
• W251569704 cites W2155201524 @default.
• W251569704 cites W2156645589 @default.
• W251569704 cites W2162904105 @default.
• W251569704 cites W2313968233 @default.
• W251569704 cites W2317224907 @default.
• W251569704 cites W2319406060 @default.
• W251569704 cites W2326124692 @default.
• W251569704 cites W2335362604 @default.
• W251569704 cites W2419439396 @default.
• W251569704 cites W2030162611 @default.
• W251569704 doi "https://doi.org/10.1016/b978-0-12-411508-8.00006-2" @default.
• W251569704 hasPublicationYear "2015" @default.
• W251569704 type Work @default.
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• W251569704 citedByCount "2" @default.

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