FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2515702573> ?p ?o ?g. }

• W2515702573 endingPage "70027" @default.
• W2515702573 startingPage "70011" @default.
• W2515702573 abstract "// Takaaki Oba 1 , Hiroto Izumi 2 , Ken-ichi Ito 1 1 Division of Breast, Endocrine and Respiratory Surgery, Department of Surgery (II), Shinshu University School of Medicine, Matsumoto, Japan 2 Department of Occupational Pneumology, Institute of Industrial Ecological Sciences, University of Occupational and Environmental Health, Kitakyushu, Japan Correspondence to: Ken-ichi Ito, email: kenito@shinshu-u.ac.jp Keywords: eribulin, drug resistance, breast cancer, ABCB1, ABCC11 Received: May 13, 2016      Accepted: August 09, 2016      Published: August 31, 2016 ABSTRACT This study aimed to elucidate the mechanisms underlying the resistance of breast cancer to eribulin. Seven eribulin-resistant breast cancer cell lines (MCF7/E, BT474/E, ZR75-1/E, SKBR3/E, MDA-MB-231/E, Hs578T/E, and MDA-MB-157/E) were established. mRNA and protein expression of ATP-binding cassette subfamily B member 1 (ABCB1) and subfamily C member 11 (ABCC11) increased in all eribulin-resistant cell lines compared to the parental cell lines. When ABCB1 or ABCC11 expression was inhibited by small interfering RNA in MCF7/E, BT474/E, and MDA-MB-231/E cells, eribulin sensitivity was partially restored. Moreover, eribulin resistance was attenuated additively by inhibiting ABCB1 and ABCC11 in MCF7/E cells. Additionally, overexpression of exogenous ABCB1 or ABCC11 in HEK293T cells conferred resistance to eribulin. MCF7/E and MDA-MB-231/E cells showed cross-resistance to paclitaxel, doxorubicin, and fluorouracil. Inhibition of ABCB1 partially restored paclitaxel and doxorubicin sensitivity. Partial restoration of fluorouracil sensitivity was induced by inhibiting ABCC11 in MCF7/E and MDA-MB-231/E cells. Both ABCB1 and ABCC11 are involved in the development of eribulin resistance in breast cancer cells in vitro regardless of the breast cancer subtype. Thus, ABCB1 and ABCC11 expression may be used as a biomarker for predicting the response to eribulin in patients with breast cancer. Concomitant inhibition of ABCB1 and ABCC11 might help enhance the antitumor effects of eribulin." @default.
• W2515702573 created "2016-09-16" @default.
• W2515702573 creator A5014931636 @default.
• W2515702573 creator A5049076885 @default.
• W2515702573 creator A5086349111 @default.
• W2515702573 date "2016-08-31" @default.
• W2515702573 modified "2023-10-08" @default.
• W2515702573 title "ABCB1 and ABCC11 confer resistance to eribulin in breast cancer cell lines" @default.
• W2515702573 cites W1494949608 @default.
• W2515702573 cites W1605523334 @default.
• W2515702573 cites W1721237546 @default.
• W2515702573 cites W1907447669 @default.
• W2515702573 cites W1967314557 @default.
• W2515702573 cites W1985998919 @default.
• W2515702573 cites W1986040702 @default.
• W2515702573 cites W1992069798 @default.
• W2515702573 cites W1999203523 @default.
• W2515702573 cites W2000610587 @default.
• W2515702573 cites W2005064657 @default.
• W2515702573 cites W2022008113 @default.
• W2515702573 cites W2024317644 @default.
• W2515702573 cites W2026986078 @default.
• W2515702573 cites W2028533496 @default.
• W2515702573 cites W2035248522 @default.
• W2515702573 cites W2037103758 @default.
• W2515702573 cites W2040315766 @default.
• W2515702573 cites W2040628852 @default.
• W2515702573 cites W2042674837 @default.
• W2515702573 cites W2055142365 @default.
• W2515702573 cites W2065508314 @default.
• W2515702573 cites W2071831214 @default.
• W2515702573 cites W2101830709 @default.
• W2515702573 cites W2110790042 @default.
• W2515702573 cites W2110980033 @default.
• W2515702573 cites W2113637823 @default.
• W2515702573 cites W2115044497 @default.
• W2515702573 cites W2116400584 @default.
• W2515702573 cites W2123851255 @default.
• W2515702573 cites W2127152525 @default.
• W2515702573 cites W2127564111 @default.
• W2515702573 cites W2133408654 @default.
• W2515702573 cites W2137221887 @default.
• W2515702573 cites W2148365177 @default.
• W2515702573 cites W2158351297 @default.
• W2515702573 cites W2168070336 @default.
• W2515702573 cites W2171172435 @default.
• W2515702573 cites W2173858545 @default.
• W2515702573 cites W2174049160 @default.
• W2515702573 cites W2297248108 @default.
• W2515702573 cites W2422600887 @default.
• W2515702573 cites W2512454832 @default.
• W2515702573 cites W43589343 @default.
• W2515702573 cites W4362218353 @default.
• W2515702573 doi "https://doi.org/10.18632/oncotarget.11727" @default.
• W2515702573 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5342531" @default.
• W2515702573 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27588398" @default.
• W2515702573 hasPublicationYear "2016" @default.
• W2515702573 type Work @default.
• W2515702573 sameAs 2515702573 @default.
• W2515702573 citedByCount "26" @default.
• W2515702573 countsByYear W25157025732017 @default.
• W2515702573 countsByYear W25157025732018 @default.
• W2515702573 countsByYear W25157025732019 @default.
• W2515702573 countsByYear W25157025732020 @default.
• W2515702573 countsByYear W25157025732021 @default.
• W2515702573 countsByYear W25157025732022 @default.
• W2515702573 countsByYear W25157025732023 @default.
• W2515702573 crossrefType "journal-article" @default.
• W2515702573 hasAuthorship W2515702573A5014931636 @default.
• W2515702573 hasAuthorship W2515702573A5049076885 @default.
• W2515702573 hasAuthorship W2515702573A5086349111 @default.
• W2515702573 hasBestOaLocation W25157025731 @default.
• W2515702573 hasConcept C121608353 @default.
• W2515702573 hasConcept C126322002 @default.
• W2515702573 hasConcept C143998085 @default.
• W2515702573 hasConcept C1491633281 @default.
• W2515702573 hasConcept C185592680 @default.
• W2515702573 hasConcept C191560914 @default.
• W2515702573 hasConcept C2775930923 @default.
• W2515702573 hasConcept C2776387010 @default.
• W2515702573 hasConcept C2776694085 @default.
• W2515702573 hasConcept C2777292972 @default.
• W2515702573 hasConcept C2780932548 @default.
• W2515702573 hasConcept C2781303535 @default.
• W2515702573 hasConcept C2994423619 @default.
• W2515702573 hasConcept C502942594 @default.
• W2515702573 hasConcept C530470458 @default.
• W2515702573 hasConcept C55493867 @default.
• W2515702573 hasConcept C71924100 @default.
• W2515702573 hasConcept C98274493 @default.
• W2515702573 hasConceptScore W2515702573C121608353 @default.
• W2515702573 hasConceptScore W2515702573C126322002 @default.
• W2515702573 hasConceptScore W2515702573C143998085 @default.
• W2515702573 hasConceptScore W2515702573C1491633281 @default.
• W2515702573 hasConceptScore W2515702573C185592680 @default.
• W2515702573 hasConceptScore W2515702573C191560914 @default.
• W2515702573 hasConceptScore W2515702573C2775930923 @default.
• W2515702573 hasConceptScore W2515702573C2776387010 @default.

• next