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- W2515722568 abstract "This study aimed to determine the prevalence and factors associated with Potentially Harmful Drug-drug interactions (PHDDIs) in community-dwelling elderly people (60 + years) in Bambui and identify the drugs most frequently involved in these events and characterize these interactions regard to severity. The study included 1,132 elderly people who used two or more drugs simultaneously. These participants were predominantly female (68.6%), aged between60-69 years (54.8%), and 84.2 % had at least one of the studied chronic diseases. Were consumed on average 4.2 drugs per participant, and the median prevalence of consumed the five or more drugs was 36.1%. The prevalence of PHDDIs was 11.9%, of which 13.2% were classified as severe and 66.5% moderate. The drugs most frequently involved in PHDDIs werediclofenac (10.2%) and ephedrine (9.8%) and the most common combination wastheophylline + ephedrine (18.2%). The therapeutic classes acting on cardiovascular system (36.8%) and musculoskeletal system (27.8%) were the most frequent in all PHDDIs. The occurrence of IMPPs was more frequent among users of polypharmacy among those undergoing hospitalization and with a greater number of medical visits,but only polypharmacy remained independently associated with the event (OR = 4.49, 95% CI 2.93 to 6.87). In multivariate analysis, the chance of exposure to PHDDIs were lower among those with one or two chronic conditions investigated, compared to those without these conditions. The study have a contribution relevant to improving quality of prescribing, integrating the efforts to strengthen pharmacovigilance actions, especially in the elderly population, where the risk the use of medicines are exacerbated by physiological problems own aging. Also, come help fill the lack of scientific literature on the topic in elderly populations residing inthe community, in a distinctive setting of the health service, especially the hospital." @default.
- W2515722568 created "2016-09-16" @default.
- W2515722568 creator A5016116910 @default.
- W2515722568 date "2014-01-01" @default.
- W2515722568 modified "2023-09-23" @default.
- W2515722568 title "Detecção e avaliação das interações medicamentosas potencialmente prejudiciais em idosos: projeto Bambuí" @default.
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