FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2515958533> ?p ?o ?g. }

• W2515958533 endingPage "3959" @default.
• W2515958533 startingPage "3948" @default.
• W2515958533 abstract "Linker histones bind to the nucleosome and regulate the structure and function of chromatin. We have previously shown that the globular domains of chicken H5 and Drosophila H1 linker histones bind to the nucleosome with on- or off-dyad modes, respectively. To explore the determinant for the distinct binding modes, we investigated the binding of a mutant globular domain of H5 to the nucleosome. This mutant, termed GH5_pMut, includes substitutions of five globular domain residues of H5 with the corresponding residues in the globular domain of Drosophila H1. The residues at these five positions play important roles in nucleosome binding by either H5 or Drosophila H1. NMR and spin-labeling experiments showed that GH5_pMut bound to the nucleosome off the dyad. We further found that the nucleosome array condensed by either the GH5_pMut or the globular domain of Drosophila H1 displayed a similar sedimentation coefficient, whereas the same nucleosome array condensed by the wild-type globular domain of H5 showed a much larger sedimentation coefficient. Moreover, NMR and spin-labeling results from the study of the nucleosome in complex with the full-length human linker histone H1.0, whose globular domain shares high sequence conservation with the corresponding globular domain of H5, are consistent with an on-dyad binding mode. Taken together, our results suggest that a small number of residues in the globular domain of a linker histone can control its binding location on the nucleosome and higher-order chromatin structure." @default.
• W2515958533 created "2016-09-16" @default.
• W2515958533 creator A5002454695 @default.
• W2515958533 creator A5034992673 @default.
• W2515958533 creator A5068709307 @default.
• W2515958533 creator A5069137667 @default.
• W2515958533 creator A5072545375 @default.
• W2515958533 creator A5074374757 @default.
• W2515958533 date "2016-10-01" @default.
• W2515958533 modified "2023-10-16" @default.
• W2515958533 title "A Small Number of Residues Can Determine if Linker Histones Are Bound On or Off Dyad in the Chromatosome" @default.
• W2515958533 cites W135309739 @default.
• W2515958533 cites W1496958584 @default.
• W2515958533 cites W1568313174 @default.
• W2515958533 cites W1571482483 @default.
• W2515958533 cites W1572088192 @default.
• W2515958533 cites W160911776 @default.
• W2515958533 cites W1642886682 @default.
• W2515958533 cites W1773400868 @default.
• W2515958533 cites W1813751289 @default.
• W2515958533 cites W1963525648 @default.
• W2515958533 cites W1966182688 @default.
• W2515958533 cites W1975317507 @default.
• W2515958533 cites W1978107331 @default.
• W2515958533 cites W1981831332 @default.
• W2515958533 cites W1983159345 @default.
• W2515958533 cites W1985367658 @default.
• W2515958533 cites W1988294401 @default.
• W2515958533 cites W1993633154 @default.
• W2515958533 cites W1993646828 @default.
• W2515958533 cites W1993822465 @default.
• W2515958533 cites W1996683105 @default.
• W2515958533 cites W2000392583 @default.
• W2515958533 cites W2001591980 @default.
• W2515958533 cites W2003727007 @default.
• W2515958533 cites W2006794421 @default.
• W2515958533 cites W2008890975 @default.
• W2515958533 cites W2010048885 @default.
• W2515958533 cites W2013571070 @default.
• W2515958533 cites W2017314177 @default.
• W2515958533 cites W2024438743 @default.
• W2515958533 cites W2029872364 @default.
• W2515958533 cites W2030023744 @default.
• W2515958533 cites W2030728145 @default.
• W2515958533 cites W2042225218 @default.
• W2515958533 cites W2047422719 @default.
• W2515958533 cites W2050489395 @default.
• W2515958533 cites W2053538195 @default.
• W2515958533 cites W2064008318 @default.
• W2515958533 cites W2064944332 @default.
• W2515958533 cites W2071478793 @default.
• W2515958533 cites W2076446466 @default.
• W2515958533 cites W2080479776 @default.
• W2515958533 cites W2083959000 @default.
• W2515958533 cites W2093369049 @default.
• W2515958533 cites W2097041586 @default.
• W2515958533 cites W2101002332 @default.
• W2515958533 cites W2102971263 @default.
• W2515958533 cites W2122953886 @default.
• W2515958533 cites W2128254777 @default.
• W2515958533 cites W2133481388 @default.
• W2515958533 cites W2144792857 @default.
• W2515958533 cites W2145379834 @default.
• W2515958533 cites W2153983456 @default.
• W2515958533 cites W2158060231 @default.
• W2515958533 cites W2169782046 @default.
• W2515958533 cites W2169821755 @default.
• W2515958533 cites W2233692211 @default.
• W2515958533 cites W2234142868 @default.
• W2515958533 doi "https://doi.org/10.1016/j.jmb.2016.08.016" @default.
• W2515958533 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/6291011" @default.
• W2515958533 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27558112" @default.
• W2515958533 hasPublicationYear "2016" @default.
• W2515958533 type Work @default.
• W2515958533 sameAs 2515958533 @default.
• W2515958533 citedByCount "45" @default.
• W2515958533 countsByYear W25159585332017 @default.
• W2515958533 countsByYear W25159585332018 @default.
• W2515958533 countsByYear W25159585332019 @default.
• W2515958533 countsByYear W25159585332020 @default.
• W2515958533 countsByYear W25159585332021 @default.
• W2515958533 countsByYear W25159585332022 @default.
• W2515958533 countsByYear W25159585332023 @default.
• W2515958533 crossrefType "journal-article" @default.
• W2515958533 hasAuthorship W2515958533A5002454695 @default.
• W2515958533 hasAuthorship W2515958533A5034992673 @default.
• W2515958533 hasAuthorship W2515958533A5068709307 @default.
• W2515958533 hasAuthorship W2515958533A5069137667 @default.
• W2515958533 hasAuthorship W2515958533A5072545375 @default.
• W2515958533 hasAuthorship W2515958533A5074374757 @default.
• W2515958533 hasBestOaLocation W25159585332 @default.
• W2515958533 hasConcept C101152365 @default.
• W2515958533 hasConcept C105168689 @default.
• W2515958533 hasConcept C111919701 @default.
• W2515958533 hasConcept C12554922 @default.
• W2515958533 hasConcept C164974683 @default.
• W2515958533 hasConcept C185592680 @default.
• W2515958533 hasConcept C193646685 @default.

• next