Matches in SemOpenAlex for { <https://semopenalex.org/work/W2516052007> ?p ?o ?g. }
- W2516052007 abstract "Human DNA2 (hDNA2) contains both a helicase and a nuclease domain within the same polypeptide. The nuclease of hDNA2 is involved in a variety of DNA metabolic processes. Little is known about the role of the hDNA2 helicase. Using bulk and single-molecule approaches, we show that hDNA2 is a processive helicase capable of unwinding kilobases of dsDNA in length. The nuclease activity prevents the engagement of the helicase by competing for the same substrate, hence prominent DNA unwinding by hDNA2 alone can only be observed using the nuclease-deficient variant. We show that the helicase of hDNA2 functionally integrates with BLM or WRN helicases to promote dsDNA degradation by forming a heterodimeric molecular machine. This collectively suggests that the hDNA2 motor promotes the enzyme's capacity to degrade dsDNA in conjunction with BLM or WRN and thus promote the repair of broken DNA." @default.
- W2516052007 created "2016-09-16" @default.
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- W2516052007 creator A5074416216 @default.
- W2516052007 date "2016-09-09" @default.
- W2516052007 modified "2023-09-24" @default.
- W2516052007 title "Human DNA2 possesses a cryptic DNA unwinding activity that functionally integrates with BLM or WRN helicases" @default.
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- W2516052007 doi "https://doi.org/10.7554/elife.18574" @default.
- W2516052007 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5030094" @default.
- W2516052007 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27612385" @default.
- W2516052007 hasPublicationYear "2016" @default.
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