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- W2516065887 abstract "Toxicity studies of nivalenol (NIV) by single and repeated oral administrations were carried out using male and female F344 rats (5 weeks old). NIV solution was given by single administration using a stomach tube. Sedation, eyelid closure, staggering gait and diarrhea, and congestion of the lung and digestive tract were observed. Oral LD50 value was 19.5mg/kg in both sexes. As a subacute toxicity test, NIV solution was given orally at daily doses of 0.4 and 2.0mg/kg·bw for 30 days, and animals were killed on the 15th and 30th days. No significant changes were found in hematological or biochemical parameters. The liver and spleen weights were significantly increased at the dose of 2.0mg/kg·bw/day, but no histological changes were seen. Further tests will be needed to identify the no-observable-effect level of NIV." @default.
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- W2516065887 date "1990-01-01" @default.
- W2516065887 modified "2023-09-27" @default.
- W2516065887 title "Single and Repeated Oral Administration Toxicity Studies of Nivalenol in F344 Rats" @default.
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