Matches in SemOpenAlex for { <https://semopenalex.org/work/W2516133025> ?p ?o ?g. }
- W2516133025 abstract "Resistance to the carbamate insecticide bendiocarb is emerging in Anopheles gambiae populations from the city of Yaoundé in Cameroon. However, the molecular basis of this resistance remains uncharacterized. The present study objective is to investigate mechanisms promoting resistance to bendiocarb in An. gambiae populations from Yaoundé. The level of susceptibility of An. gambiae s.l. to bendiocarb 0.1 % was assessed from 2010 to 2013 using bioassays. Mosquitoes resistant to bendiocarb, unexposed and susceptible mosquitoes were screened for the presence of the Ace-1R mutation using TaqMan assays. Microarray analyses were performed to assess the pattern of genes differentially expressed between resistant, unexposed and susceptible. Bendiocarb resistance was more prevalent in mosquitoes originating from cultivated sites compared to those from polluted and unpolluted sites. Both An. gambiae and Anopheles coluzzii were found to display resistance to bendiocarb. No G119S mutation was detected suggesting that resistance was mainly metabolic. Microarray analysis revealed the over-expression of several cytochrome P450 s genes including cyp6z3, cyp6z1, cyp12f2, cyp6m3 and cyp6p4. Gene ontology (GO) enrichment analysis supported the detoxification role of cytochrome P450 s with several GO terms associated with P450 activity significantly enriched in resistant samples. Other detoxification genes included UDP-glucosyl transferases, glutathione-S transferases and ABC transporters. The study highlights the probable implication of metabolic mechanisms in bendiocarb resistance in An. gambiae populations from Yaoundé and stresses the need for further studies leading to functional validation of detoxification genes involved in this resistance." @default.
- W2516133025 created "2016-09-16" @default.
- W2516133025 creator A5004267917 @default.
- W2516133025 creator A5008540849 @default.
- W2516133025 creator A5008576984 @default.
- W2516133025 creator A5009370045 @default.
- W2516133025 creator A5009775338 @default.
- W2516133025 creator A5037724218 @default.
- W2516133025 creator A5056177272 @default.
- W2516133025 date "2016-08-22" @default.
- W2516133025 modified "2023-10-18" @default.
- W2516133025 title "Investigation of mechanisms of bendiocarb resistance in Anopheles gambiae populations from the city of Yaoundé, Cameroon" @default.
- W2516133025 cites W1644246264 @default.
- W2516133025 cites W1838539100 @default.
- W2516133025 cites W1894396536 @default.
- W2516133025 cites W1911482274 @default.
- W2516133025 cites W1960744434 @default.
- W2516133025 cites W1967564010 @default.
- W2516133025 cites W1969935265 @default.
- W2516133025 cites W1980750519 @default.
- W2516133025 cites W1985288268 @default.
- W2516133025 cites W1985596043 @default.
- W2516133025 cites W1993782327 @default.
- W2516133025 cites W2003271727 @default.
- W2516133025 cites W2014404765 @default.
- W2516133025 cites W2015825096 @default.
- W2516133025 cites W2022220017 @default.
- W2516133025 cites W2025408345 @default.
- W2516133025 cites W2035282516 @default.
- W2516133025 cites W2060444887 @default.
- W2516133025 cites W2062155365 @default.
- W2516133025 cites W2063113424 @default.
- W2516133025 cites W2064261657 @default.
- W2516133025 cites W2068438096 @default.
- W2516133025 cites W2070737194 @default.
- W2516133025 cites W2071243401 @default.
- W2516133025 cites W2071718890 @default.
- W2516133025 cites W2081207002 @default.
- W2516133025 cites W2095277223 @default.
- W2516133025 cites W2096953437 @default.
- W2516133025 cites W2097381571 @default.
- W2516133025 cites W2098086227 @default.
- W2516133025 cites W2102566739 @default.
- W2516133025 cites W2104103976 @default.
- W2516133025 cites W2105640468 @default.
- W2516133025 cites W2105672275 @default.
- W2516133025 cites W2106392681 @default.
- W2516133025 cites W2108244474 @default.
- W2516133025 cites W2108685809 @default.
- W2516133025 cites W2114570899 @default.
- W2516133025 cites W2119285126 @default.
- W2516133025 cites W2121256782 @default.
- W2516133025 cites W2121626072 @default.
- W2516133025 cites W2123036062 @default.
- W2516133025 cites W2126196713 @default.
- W2516133025 cites W2127704588 @default.
- W2516133025 cites W2128287083 @default.
- W2516133025 cites W2128444567 @default.
- W2516133025 cites W2130164188 @default.
- W2516133025 cites W2131181401 @default.
- W2516133025 cites W2131345844 @default.
- W2516133025 cites W2133465414 @default.
- W2516133025 cites W2138679098 @default.
- W2516133025 cites W2148279352 @default.
- W2516133025 cites W2152161309 @default.
- W2516133025 cites W2153086414 @default.
- W2516133025 cites W2158217645 @default.
- W2516133025 cites W2159147345 @default.
- W2516133025 cites W2164665366 @default.
- W2516133025 cites W2166537326 @default.
- W2516133025 cites W2171454222 @default.
- W2516133025 cites W4239894333 @default.
- W2516133025 cites W4298218543 @default.
- W2516133025 doi "https://doi.org/10.1186/s12936-016-1483-3" @default.
- W2516133025 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/4994282" @default.
- W2516133025 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27549778" @default.
- W2516133025 hasPublicationYear "2016" @default.
- W2516133025 type Work @default.
- W2516133025 sameAs 2516133025 @default.
- W2516133025 citedByCount "44" @default.
- W2516133025 countsByYear W25161330252017 @default.
- W2516133025 countsByYear W25161330252018 @default.
- W2516133025 countsByYear W25161330252019 @default.
- W2516133025 countsByYear W25161330252020 @default.
- W2516133025 countsByYear W25161330252021 @default.
- W2516133025 countsByYear W25161330252022 @default.
- W2516133025 countsByYear W25161330252023 @default.
- W2516133025 crossrefType "journal-article" @default.
- W2516133025 hasAuthorship W2516133025A5004267917 @default.
- W2516133025 hasAuthorship W2516133025A5008540849 @default.
- W2516133025 hasAuthorship W2516133025A5008576984 @default.
- W2516133025 hasAuthorship W2516133025A5009370045 @default.
- W2516133025 hasAuthorship W2516133025A5009775338 @default.
- W2516133025 hasAuthorship W2516133025A5037724218 @default.
- W2516133025 hasAuthorship W2516133025A5056177272 @default.
- W2516133025 hasBestOaLocation W25161330251 @default.
- W2516133025 hasConcept C161176658 @default.
- W2516133025 hasConcept C18903297 @default.
- W2516133025 hasConcept C190612196 @default.
- W2516133025 hasConcept C203014093 @default.