FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2516269358> ?p ?o ?g. }

• W2516269358 endingPage "432" @default.
• W2516269358 startingPage "424" @default.
• W2516269358 abstract "Transplantation of pancreatic islets is the most reliable treatment for Type 1 diabetes. However cell death mediated by hypoxia is considered as one of the main difficulties hindering success in islet transplantation. The aim of our experiment was to investigate the role of small molecules in survival of Islet like cell aggregates (ICAs) engineered from umbilical cord matrix under oxygen deprived condition (<5% O2). ICAs were analyzed for cell death via fluoroscein diacetate/propidium iodide (FDA/PI) staining, estimation of Caspase 3 and free radical release in presence and absence of small molecules. The samples were also analyzed for the presence of hypoxia inducible factor 1α (HIF1α) at both transcriptional and translational level. The addition of small molecules showed profound defensive effect on ICAs under hypoxic environment as evidenced by their viability and insulin secretion compared to untreated ICAs. The combinations of Eicosapentaenoic acid (EPA), Docosahexaenoic acid(DHA) and metformin and EPA, DHAandγ amino butyric acid (GABA) acted as anti-apoptotic agents for human ICAs when exposed to 1% O2 for 48 h. The combinations of the small molecules reduced the total reactive oxygen species and malonaldehyde (MDA) levels and enhanced the production of glutathione peroxidise (GPx) enzyme under hypoxic conditions. Finally the increase in HIF1α at both protein and gene level confirmed the defensive effect of the additives in hypoxia. These results suggest that the combination of small molecules maintained the viability and functionality of the ICAs in hypoxia by up-regulating HIF1α expression and down regulating the Caspase 3 activity." @default.
• W2516269358 created "2016-09-16" @default.
• W2516269358 creator A5053638858 @default.
• W2516269358 creator A5084809927 @default.
• W2516269358 date "2016-11-01" @default.
• W2516269358 modified "2023-10-17" @default.
• W2516269358 title "Small molecules exert anti-apoptotic effect and reduce oxidative stress augmenting insulin secretion in stem cells engineered islets against hypoxia" @default.
• W2516269358 cites W1486008282 @default.
• W2516269358 cites W1842144698 @default.
• W2516269358 cites W1968691147 @default.
• W2516269358 cites W1976887222 @default.
• W2516269358 cites W1981106016 @default.
• W2516269358 cites W2025725129 @default.
• W2516269358 cites W2031778182 @default.
• W2516269358 cites W2033300061 @default.
• W2516269358 cites W2047136983 @default.
• W2516269358 cites W2047786130 @default.
• W2516269358 cites W2050397606 @default.
• W2516269358 cites W2051135812 @default.
• W2516269358 cites W2069160249 @default.
• W2516269358 cites W2087497757 @default.
• W2516269358 cites W2098760341 @default.
• W2516269358 cites W2104622496 @default.
• W2516269358 cites W2106964014 @default.
• W2516269358 cites W2113544353 @default.
• W2516269358 cites W2123838232 @default.
• W2516269358 cites W2145852003 @default.
• W2516269358 cites W2150803022 @default.
• W2516269358 cites W2154024784 @default.
• W2516269358 cites W2156044622 @default.
• W2516269358 cites W2163579288 @default.
• W2516269358 cites W2165571979 @default.
• W2516269358 cites W2315296675 @default.
• W2516269358 cites W2341492543 @default.
• W2516269358 cites W318506521 @default.
• W2516269358 doi "https://doi.org/10.1016/j.ejphar.2016.09.012" @default.
• W2516269358 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27614129" @default.
• W2516269358 hasPublicationYear "2016" @default.
• W2516269358 type Work @default.
• W2516269358 sameAs 2516269358 @default.
• W2516269358 citedByCount "6" @default.
• W2516269358 countsByYear W25162693582017 @default.
• W2516269358 countsByYear W25162693582018 @default.
• W2516269358 countsByYear W25162693582020 @default.
• W2516269358 countsByYear W25162693582021 @default.
• W2516269358 crossrefType "journal-article" @default.
• W2516269358 hasAuthorship W2516269358A5053638858 @default.
• W2516269358 hasAuthorship W2516269358A5084809927 @default.
• W2516269358 hasConcept C126322002 @default.
• W2516269358 hasConcept C134018914 @default.
• W2516269358 hasConcept C165220095 @default.
• W2516269358 hasConcept C178790620 @default.
• W2516269358 hasConcept C185592680 @default.
• W2516269358 hasConcept C190283241 @default.
• W2516269358 hasConcept C2775934118 @default.
• W2516269358 hasConcept C2776151105 @default.
• W2516269358 hasConcept C2779306644 @default.
• W2516269358 hasConcept C2911091166 @default.
• W2516269358 hasConcept C31573885 @default.
• W2516269358 hasConcept C48349386 @default.
• W2516269358 hasConcept C53227056 @default.
• W2516269358 hasConcept C540031477 @default.
• W2516269358 hasConcept C55493867 @default.
• W2516269358 hasConcept C71924100 @default.
• W2516269358 hasConcept C7836513 @default.
• W2516269358 hasConcept C86803240 @default.
• W2516269358 hasConcept C98274493 @default.
• W2516269358 hasConceptScore W2516269358C126322002 @default.
• W2516269358 hasConceptScore W2516269358C134018914 @default.
• W2516269358 hasConceptScore W2516269358C165220095 @default.
• W2516269358 hasConceptScore W2516269358C178790620 @default.
• W2516269358 hasConceptScore W2516269358C185592680 @default.
• W2516269358 hasConceptScore W2516269358C190283241 @default.
• W2516269358 hasConceptScore W2516269358C2775934118 @default.
• W2516269358 hasConceptScore W2516269358C2776151105 @default.
• W2516269358 hasConceptScore W2516269358C2779306644 @default.
• W2516269358 hasConceptScore W2516269358C2911091166 @default.
• W2516269358 hasConceptScore W2516269358C31573885 @default.
• W2516269358 hasConceptScore W2516269358C48349386 @default.
• W2516269358 hasConceptScore W2516269358C53227056 @default.
• W2516269358 hasConceptScore W2516269358C540031477 @default.
• W2516269358 hasConceptScore W2516269358C55493867 @default.
• W2516269358 hasConceptScore W2516269358C71924100 @default.
• W2516269358 hasConceptScore W2516269358C7836513 @default.
• W2516269358 hasConceptScore W2516269358C86803240 @default.
• W2516269358 hasConceptScore W2516269358C98274493 @default.
• W2516269358 hasFunder F4320322932 @default.
• W2516269358 hasLocation W25162693581 @default.
• W2516269358 hasLocation W25162693582 @default.
• W2516269358 hasOpenAccess W2516269358 @default.
• W2516269358 hasPrimaryLocation W25162693581 @default.
• W2516269358 hasRelatedWork W1965464649 @default.
• W2516269358 hasRelatedWork W2009294659 @default.
• W2516269358 hasRelatedWork W2066399525 @default.
• W2516269358 hasRelatedWork W2165817281 @default.
• W2516269358 hasRelatedWork W2348080834 @default.
• W2516269358 hasRelatedWork W2349543669 @default.
• W2516269358 hasRelatedWork W2373944708 @default.

• next