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• W2516272580 abstract "Event Abstract Back to Event Abnormal functional connectivity in progressive supra nuclear palsy and cortico basal syndrome:A resting state fMRI study Komal Bharti1, Matteo Bologna2, Neeraj Upadhyay1, Maria Cristina Piatella1, Antonio Suppa1, 2, Nikolaos Petsas1, Costanza Gianni1, Francesca Tona1, Alfredo Berardelli1, 2 and Patrizia Pantano1, 2* 1 Sapienza University of Rome, Department of Neurology and Psychiatry, Italy 2 Neuromed Institute IRCCS, Italy Studies on resting state functional connectivity (rsFC) in patients affected by taupathies with parkinsonism are scarce in literature. Few studies are available in patients with progressive supranuclear palsy (PSP), while no study has been performed in patients with corticobasal syndrome (CBS). The purpose of this study was to investigate within- and between-network rsFC abnormalities in these two forms of taupathies, using independent component analysis. For this purpose we recruited eleven patients with PSP, 11 patients with CBS and 11 age and gender matched healthy subjects. Compared to healthy subjects, significant increase in within-network rsFC was observed in both PSP and CBS patients with more widespread abnormalities being present in PSP. Increased rsFC within the cerebellar network was positively correlated with motor scores. With respect to healthy subjects, functional connections between the salience network and executive control network as well as between the anterior and posterior components of default mode network were significantly decreased in PSP, those between the cerebellum and orbitofrontal networks were significantly increased in both PSP and CBS patients; rsFC between the orbitofrontal and sensorimotor networks was lower in PSP than in CBS. We also found between-network rsFC in salience network and executive control network positively correlated with Mini-Mental State Examination (MMSE) and negatively with motor severity in patients with PSP. The study provides evidence of functional brain reorganisation in both forms of taupathies, with more severe rsFC abnormalities in PSP. Within-network rsFC increase may represent low-frequency higher synchronisation in damaged neurons while between-network rsFC abnormalities may reflect loss of structural integrity of long–range white matter fibers. Keywords: Resting state functional magnetic resonance imaging, resting state networks, functional connectivity, progressive supra nuclear palsy, Corticobasal Syndrome Conference: SAN2016 Meeting, Corfu, Greece, 6 Oct - 9 Oct, 2016. Presentation Type: Oral Presentation in SAN 2016 Conference Topic: Oral Presentations Citation: Bharti K, Bologna M, Upadhyay N, Piatella M, Suppa A, Petsas N, Gianni C, Tona F, Berardelli A and Pantano P (2016). Abnormal functional connectivity in progressive supra nuclear palsy and cortico basal syndrome:A resting state fMRI study. Conference Abstract: SAN2016 Meeting. doi: 10.3389/conf.fnhum.2016.220.00027 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 29 Jul 2016; Published Online: 30 Jul 2016. * Correspondence: Prof. Patrizia Pantano, Sapienza University of Rome, Department of Neurology and Psychiatry, Rome, 00185, Italy, patrizia.pantano@uniroma1.it Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Komal Bharti Matteo Bologna Neeraj Upadhyay Maria Cristina Piatella Antonio Suppa Nikolaos Petsas Costanza Gianni Francesca Tona Alfredo Berardelli Patrizia Pantano Google Komal Bharti Matteo Bologna Neeraj Upadhyay Maria Cristina Piatella Antonio Suppa Nikolaos Petsas Costanza Gianni Francesca Tona Alfredo Berardelli Patrizia Pantano Google Scholar Komal Bharti Matteo Bologna Neeraj Upadhyay Maria Cristina Piatella Antonio Suppa Nikolaos Petsas Costanza Gianni Francesca Tona Alfredo Berardelli Patrizia Pantano PubMed Komal Bharti Matteo Bologna Neeraj Upadhyay Maria Cristina Piatella Antonio Suppa Nikolaos Petsas Costanza Gianni Francesca Tona Alfredo Berardelli Patrizia Pantano Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2516272580 title "Abnormal functional connectivity in progressive supra nuclear palsy and cortico basal syndrome:A resting state fMRI study" @default.
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