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- W2516347749 abstract "Background: Ring Finger protein 135 (RNF135), located on 17q11.2, is a RING domain containing E3 ubiquitin ligase and functioned as the E3 ubiquitin ligase. Objective: The aim of this study was to investigate the expression and function of RNF135 in human glioblastoma. Material and methods: Levels of RNF135 expression were measured in glioblastoma and normal brain (NB) tissues samples. Stably decreased expression of RNF135 was established by the pLVTHM-GFP lentiviral RNAi expression system. Molecular mechanisms and the effect of RNF135 on cell growth and migration were investigated using MTT assay, wound healing assay, transwell migration assay, Flow cytometry analysis, western blot assay, immunofluorescence double labeling and tumorigenesis in nude mice. Results: In our study, we confirmed that RNF135 was up-regulated in glioblastoma tissues compared with normal tissues, and RNF135 knockdown inhibited proliferation, migration and cell cycle arrested in G0/G1 phase of glioblastoma U87 cells in vitro.Depressing RNF135 expression, the p-Erk, and cell cycle protein CDK4 were down-regulated while p27Kip1 and p21Waf1/Cip1 were up-expressed in U87 cells in vitro Moreover, the growth of U87 cell-transplanted tumors in nude mice was inhibited by transduced with Lv-shRNF135. Conclusion: Our findings provide the biological effects of RNF135 in glioblastoma cell proliferation, migration and cell cycle, and its role in the progression of glioblastoma may be associated with ERK signal transduction pathway." @default.
- W2516347749 created "2016-09-16" @default.
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- W2516347749 date "2015-10-01" @default.
- W2516347749 modified "2023-09-24" @default.
- W2516347749 title "RNF135, a ring finger protein, promote proliferation of human glioblastoma cells in vivo and in vitro via ERK pathway" @default.
- W2516347749 doi "https://doi.org/10.1016/j.jns.2015.08.655" @default.
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