FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2516361476> ?p ?o ?g. }

• W2516361476 abstract "Recent studies show that the Agkistrodon acutus (Viperidae) (syn. Deinagkistrodon acutus) protein C activator (PCA) treats acute myocardial infarction and ischaemia-reperfusion animal models effectively, while the underlying mechanism remains unknown.To study the effect of PCA on the injury of human umbilical vein endothelial cells (HUVECs) induced by H2O2 and the underlying mechanism.Primary cultured HUVECs were pretreated with PCA (20, 40 and 80 μg/mL) for 1 h, then HUVEC apoptosis was induced by 300 μmol/mL H2O2. Apoptosis was analyzed by AnnexinV-FITC/PI, and reactive oxygen species (ROS) level was tested by flow cytometry. Colorimetric methods were used to detect the levels of NO and IL-1. In addition, real-time PCR and western blot analyses were used to detect the expression of eNOS and phospho-p38/MAPK.Morphological changes were induced by H2O2 in HUVECs. The cell survival rate was increased by 43.9, 64.0 and 80.6% in each PCA pretreated group (20, 40 and 80 μg/mL) compared to the model group. In each PCA pretreated group, oxidative stress level was also decreased to 54.7, 42.7 and 25.1%. Moreover, the level of IL-1 was decreased to 83.3, 62.2 and 30.7%. The level of NO was increased by 155.9, 232.4 and 317.6%. Apoptosis rate was decreased to 59.0, 47.7 and 32.7%. Phospho-p38 expression was downregulated, but eNOS expression was upregulated.The results suggest that PCA can effectively protect the endothelial cells from injury induced by H2O2, which may be associated with antioxidation, upregulation of eNOS and downregulation of p38-MAPK." @default.
• W2516361476 created "2016-09-16" @default.
• W2516361476 creator A5006616499 @default.
• W2516361476 creator A5021963362 @default.
• W2516361476 creator A5041744597 @default.
• W2516361476 creator A5053892310 @default.
• W2516361476 creator A5055560303 @default.
• W2516361476 creator A5071269156 @default.
• W2516361476 creator A5078404866 @default.
• W2516361476 creator A5084936138 @default.
• W2516361476 date "2016-08-30" @default.
• W2516361476 modified "2023-09-26" @default.
• W2516361476 title "Agkistrodon acutus-purified protein C activator protects human umbilical vein endothelial cells against H2O2-induced apoptosis" @default.
• W2516361476 cites W1991174176 @default.
• W2516361476 cites W1999376351 @default.
• W2516361476 cites W2004465286 @default.
• W2516361476 cites W2010868948 @default.
• W2516361476 cites W2027685796 @default.
• W2516361476 cites W2061110648 @default.
• W2516361476 cites W2072122716 @default.
• W2516361476 cites W2077999697 @default.
• W2516361476 cites W2082427741 @default.
• W2516361476 cites W2084418891 @default.
• W2516361476 cites W2085466541 @default.
• W2516361476 cites W2093369666 @default.
• W2516361476 cites W2132731612 @default.
• W2516361476 cites W2134644007 @default.
• W2516361476 cites W2140918209 @default.
• W2516361476 cites W2160079423 @default.
• W2516361476 cites W2167757432 @default.
• W2516361476 doi "https://doi.org/10.1080/13880209.2016.1224259" @default.
• W2516361476 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27572701" @default.
• W2516361476 hasPublicationYear "2016" @default.
• W2516361476 type Work @default.
• W2516361476 sameAs 2516361476 @default.
• W2516361476 citedByCount "4" @default.
• W2516361476 countsByYear W25163614762018 @default.
• W2516361476 countsByYear W25163614762019 @default.
• W2516361476 countsByYear W25163614762020 @default.
• W2516361476 crossrefType "journal-article" @default.
• W2516361476 hasAuthorship W2516361476A5006616499 @default.
• W2516361476 hasAuthorship W2516361476A5021963362 @default.
• W2516361476 hasAuthorship W2516361476A5041744597 @default.
• W2516361476 hasAuthorship W2516361476A5053892310 @default.
• W2516361476 hasAuthorship W2516361476A5055560303 @default.
• W2516361476 hasAuthorship W2516361476A5071269156 @default.
• W2516361476 hasAuthorship W2516361476A5078404866 @default.
• W2516361476 hasAuthorship W2516361476A5084936138 @default.
• W2516361476 hasConcept C104317684 @default.
• W2516361476 hasConcept C153911025 @default.
• W2516361476 hasConcept C16685009 @default.
• W2516361476 hasConcept C181199279 @default.
• W2516361476 hasConcept C185592680 @default.
• W2516361476 hasConcept C190283241 @default.
• W2516361476 hasConcept C202751555 @default.
• W2516361476 hasConcept C2776415932 @default.
• W2516361476 hasConcept C2777411675 @default.
• W2516361476 hasConcept C2777622882 @default.
• W2516361476 hasConcept C2778326061 @default.
• W2516361476 hasConcept C48349386 @default.
• W2516361476 hasConcept C51551487 @default.
• W2516361476 hasConcept C553184892 @default.
• W2516361476 hasConcept C55493867 @default.
• W2516361476 hasConcept C57074206 @default.
• W2516361476 hasConcept C62478195 @default.
• W2516361476 hasConcept C71924100 @default.
• W2516361476 hasConcept C86803240 @default.
• W2516361476 hasConceptScore W2516361476C104317684 @default.
• W2516361476 hasConceptScore W2516361476C153911025 @default.
• W2516361476 hasConceptScore W2516361476C16685009 @default.
• W2516361476 hasConceptScore W2516361476C181199279 @default.
• W2516361476 hasConceptScore W2516361476C185592680 @default.
• W2516361476 hasConceptScore W2516361476C190283241 @default.
• W2516361476 hasConceptScore W2516361476C202751555 @default.
• W2516361476 hasConceptScore W2516361476C2776415932 @default.
• W2516361476 hasConceptScore W2516361476C2777411675 @default.
• W2516361476 hasConceptScore W2516361476C2777622882 @default.
• W2516361476 hasConceptScore W2516361476C2778326061 @default.
• W2516361476 hasConceptScore W2516361476C48349386 @default.
• W2516361476 hasConceptScore W2516361476C51551487 @default.
• W2516361476 hasConceptScore W2516361476C553184892 @default.
• W2516361476 hasConceptScore W2516361476C55493867 @default.
• W2516361476 hasConceptScore W2516361476C57074206 @default.
• W2516361476 hasConceptScore W2516361476C62478195 @default.
• W2516361476 hasConceptScore W2516361476C71924100 @default.
• W2516361476 hasConceptScore W2516361476C86803240 @default.
• W2516361476 hasLocation W25163614761 @default.
• W2516361476 hasLocation W25163614762 @default.
• W2516361476 hasOpenAccess W2516361476 @default.
• W2516361476 hasPrimaryLocation W25163614761 @default.
• W2516361476 hasRelatedWork W2351932264 @default.
• W2516361476 hasRelatedWork W2353915214 @default.
• W2516361476 hasRelatedWork W2357373123 @default.
• W2516361476 hasRelatedWork W2361697175 @default.
• W2516361476 hasRelatedWork W2364000628 @default.
• W2516361476 hasRelatedWork W2364760575 @default.
• W2516361476 hasRelatedWork W2372947435 @default.
• W2516361476 hasRelatedWork W2378425588 @default.
• W2516361476 hasRelatedWork W2381381190 @default.
• W2516361476 hasRelatedWork W2383508001 @default.

• next