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• W2516459603 abstract "DAO Diseases of Aquatic Organisms Contact the journal Facebook Twitter RSS Mailing List Subscribe to our mailing list via Mailchimp HomeLatest VolumeAbout the JournalEditorsSpecials DAO 121:189-199 (2016) - DOI: https://doi.org/10.3354/dao03053 In vitro antiviral efficacy of moroxydine hydrochloride and ribavirin against grass carp reovirus and giant salamander iridovirus Xiao-Bo Yu, Xiao-Hui Chen, Li-Peng Shan, Kai Hao, Gao-Xue Wang* College of Animal Science and Technology, Northwest A&F University, Yangling, Shaanxi 712100, PR China *Corresponding author: wanggaoxue@126.com ABSTRACT: Moroxydine hydrochloride (Mor) and ribavirin (Rib) have been reported to exhibit multi-antiviral activities against DNA and RNA viruses, but their antiviral activities and pharmacologies have seldom been studied in aquaculture. This paper has selected 3 aquatic viruses including a double-stranded RNA virus (grass carp reovirus, GCRV), a single-stranded RNA virus (spring viraemia of carp virus, SVCV) and a DNA virus (giant salamander iridovirus, GSIV) for antiviral testing. The results showed that Mor and Rib can effectively control the infection of GCRV and GSIV in respective host cells. Further study was undertaken to explore the antivirus efficiencies and pharmacological mechanisms of Mor and Rib on GCRV and GSIV in vitro. Briefly, compounds showed over 50% protective effects at 15.9 µg ml-1 except for the group of GSIV-infected epithelioma papulosum cyprinid (EPC) cells treated with Mor. Moreover, Mor and Rib blocked the virus-induced cytopathic effects and apoptosis in host cells to keep the normal cellular structure. The expression of VP1 (GCRV) and major capsid protein (MCP; GSIV) gene was also significantly inhibited in the virus-infected cells when treated with Mor and Rib. Cytotoxicity assay verified the 2 compounds had no toxic effects on grass carp ovary (GCO) cells and EPC cells at ≤96 µg ml-1. In conclusion, these results indicated that exposing GCRV-infected GCO cells and GSIV-infected EPC cells to Mor and Rib could elicit significant antiviral responses, and the 2 compounds have been shown to be promising agents for viral control in the aquaculture industry. KEY WORDS: Moroxydine hydrochloride · Ribavirin · GCO cell · EPC cell · GCRV · GSIV · Apoptotic response Full text in pdf format PreviousNextCite this article as: Yu XB, Chen XH, Shan LP, Hao K, Wang GX (2016) In vitro antiviral efficacy of moroxydine hydrochloride and ribavirin against grass carp reovirus and giant salamander iridovirus. Dis Aquat Org 121:189-199. https://doi.org/10.3354/dao03053 Export citation RSS - Facebook - Tweet - linkedIn Cited by Published in DAO Vol. 121, No. 3. Online publication date: October 27, 2016 Print ISSN: 0177-5103; Online ISSN: 1616-1580 Copyright © 2016 Inter-Research." @default.
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• W2516459603 date "2016-10-27" @default.
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• W2516459603 title "In vitro antiviral efficacy of moroxydine hydrochloride and ribavirin against grass carp reovirus and giant salamander iridovirus" @default.
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