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- W2516483676 endingPage "e0161679" @default.
- W2516483676 startingPage "e0161679" @default.
- W2516483676 abstract "The adaptive mechanisms of homo- and heterosynaptic plasticity play an important role in learning and memory. In order to maintain plasticity-induced changes for longer time scales (up to several days), they have to be consolidated by transferring them from a short-lasting early-phase to a long-lasting late-phase state. The underlying processes of this synaptic consolidation are already well-known for homosynaptic plasticity, however, it is not clear whether the same processes also enable the induction and consolidation of heterosynaptic plasticity. In this study, by extending a generic calcium-based plasticity model with the processes of synaptic consolidation, we show in simulations that indeed heterosynaptic plasticity can be induced and, furthermore, consolidated by the same underlying processes as for homosynaptic plasticity. Furthermore, we show that by local diffusion processes the heterosynaptic effect can be restricted to a few synapses neighboring the homosynaptically changed ones. Taken together, this generic model reproduces many experimental results of synaptic tagging and consolidation, provides several predictions for heterosynaptic induction and consolidation, and yields insights into the complex interactions between homo- and heterosynaptic plasticity over a broad variety of time (minutes to days) and spatial scales (several micrometers)." @default.
- W2516483676 created "2016-09-16" @default.
- W2516483676 creator A5045734309 @default.
- W2516483676 creator A5071193084 @default.
- W2516483676 creator A5084861593 @default.
- W2516483676 date "2016-08-25" @default.
- W2516483676 modified "2023-10-17" @default.
- W2516483676 title "Induction and Consolidation of Calcium-Based Homo- and Heterosynaptic Potentiation and Depression" @default.
- W2516483676 cites W1538429890 @default.
- W2516483676 cites W1539683305 @default.
- W2516483676 cites W1548401665 @default.
- W2516483676 cites W1598503391 @default.
- W2516483676 cites W1733248925 @default.
- W2516483676 cites W1884265787 @default.
- W2516483676 cites W1894307146 @default.
- W2516483676 cites W1957331510 @default.
- W2516483676 cites W1963929105 @default.
- W2516483676 cites W1967019061 @default.
- W2516483676 cites W1967178540 @default.
- W2516483676 cites W1968581566 @default.
- W2516483676 cites W1969507049 @default.
- W2516483676 cites W1971367829 @default.
- W2516483676 cites W1972815737 @default.
- W2516483676 cites W1974948986 @default.
- W2516483676 cites W1975412204 @default.
- W2516483676 cites W1979009696 @default.
- W2516483676 cites W1979317467 @default.
- W2516483676 cites W1986347418 @default.
- W2516483676 cites W1990501032 @default.
- W2516483676 cites W1990561503 @default.
- W2516483676 cites W1991779336 @default.
- W2516483676 cites W1992882361 @default.
- W2516483676 cites W1993868308 @default.
- W2516483676 cites W1995001752 @default.
- W2516483676 cites W1995484013 @default.
- W2516483676 cites W1997375364 @default.
- W2516483676 cites W2002517479 @default.
- W2516483676 cites W2004797666 @default.
- W2516483676 cites W2011882079 @default.
- W2516483676 cites W2012417073 @default.
- W2516483676 cites W2014295524 @default.
- W2516483676 cites W2015701831 @default.
- W2516483676 cites W2017547127 @default.
- W2516483676 cites W2019523818 @default.
- W2516483676 cites W2021024875 @default.
- W2516483676 cites W2023913445 @default.
- W2516483676 cites W2027731726 @default.
- W2516483676 cites W2030661554 @default.
- W2516483676 cites W2034425096 @default.
- W2516483676 cites W2035774707 @default.
- W2516483676 cites W2040353213 @default.
- W2516483676 cites W2044670260 @default.
- W2516483676 cites W2047598284 @default.
- W2516483676 cites W2049511526 @default.
- W2516483676 cites W2050066016 @default.
- W2516483676 cites W2052405748 @default.
- W2516483676 cites W2055131918 @default.
- W2516483676 cites W2055354495 @default.
- W2516483676 cites W2055568369 @default.
- W2516483676 cites W2056179104 @default.
- W2516483676 cites W2060647065 @default.
- W2516483676 cites W2063206977 @default.
- W2516483676 cites W2065546903 @default.
- W2516483676 cites W2066783383 @default.
- W2516483676 cites W2067187446 @default.
- W2516483676 cites W2072949646 @default.
- W2516483676 cites W2074965724 @default.
- W2516483676 cites W2077501133 @default.
- W2516483676 cites W2078170624 @default.
- W2516483676 cites W2088093088 @default.
- W2516483676 cites W2088267783 @default.
- W2516483676 cites W2089442458 @default.
- W2516483676 cites W2092170706 @default.
- W2516483676 cites W2095202445 @default.
- W2516483676 cites W2096081604 @default.
- W2516483676 cites W2101346672 @default.
- W2516483676 cites W2103137532 @default.
- W2516483676 cites W2106308939 @default.
- W2516483676 cites W2118069376 @default.
- W2516483676 cites W2125001634 @default.
- W2516483676 cites W2125517286 @default.
- W2516483676 cites W2131023774 @default.
- W2516483676 cites W2131039108 @default.
- W2516483676 cites W2133445885 @default.
- W2516483676 cites W2139053813 @default.
- W2516483676 cites W2141232319 @default.
- W2516483676 cites W2147101007 @default.
- W2516483676 cites W2150753693 @default.
- W2516483676 cites W2153561332 @default.
- W2516483676 cites W2154045630 @default.
- W2516483676 cites W2155773585 @default.
- W2516483676 cites W2159187100 @default.
- W2516483676 cites W2160361560 @default.
- W2516483676 cites W2161432648 @default.
- W2516483676 cites W2165658101 @default.
- W2516483676 cites W2166138822 @default.
- W2516483676 cites W2182180700 @default.
- W2516483676 cites W2276533724 @default.