FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2516488001> ?p ?o ?g. }

• W2516488001 endingPage "e0161029" @default.
• W2516488001 startingPage "e0161029" @default.
• W2516488001 abstract "Twist proteins belong to the basic helix-loop-helix (bHLH) family of multifunctional transcriptional factors. These factors are known to use domains other than the common bHLH in protein-protein interactions. There has been much work characterizing the bHLH domain and the C-terminus in protein-protein interactions but despite a few attempts more focus is needed at the N-terminus. Since the region of highest diversity in Twist proteins is the N-terminus, we analyzed the conservation of this region in different vertebrate Twist proteins and study the sequence differences between Twist1 and Twist2 with emphasis on the glycine-rich regions found in Twist1. We found a highly conserved sequence motif in all Twist1 (SSSPVSPADDSLSNSEEE) and Twist2 (SSSPVSPVDSLGTSEEE) mammalian species with unknown function. Through sequence comparison we demonstrate that the Twist protein family ancestor was “Twist2-like” and the two glycine-rich regions found in Twist1 sequences were acquired late in evolution, apparently not at the same time. The second glycine-rich region started developing first in the fish vertebrate group, while the first glycine region arose afterwards within the reptiles. Disordered domain and secondary structure predictions showed that the amino acid sequence and disorder feature found at the N-terminus is highly evolutionary conserved and could be a functional site that interacts with other proteins. Detailed examination of the glycine-rich regions in the N-terminus of Twist1 demonstrate that the first region is completely aliphatic while the second region contains some polar residues that could be subject to post-translational modification. Phylogenetic and sequence space analysis showed that the Twist1 subfamily is the result of a gene duplication during Twist2 vertebrate fish evolution, and has undergone more evolutionary drift than Twist2. We identified a new signature motif that is characteristic of each Twist paralog and identified important residues within this motif that can be used to distinguish between these two paralogs, which will help reduce Twist1 and Twist2 sequence annotation errors in public databases." @default.
• W2516488001 created "2016-09-16" @default.
• W2516488001 creator A5059857304 @default.
• W2516488001 creator A5060968798 @default.
• W2516488001 creator A5064736805 @default.
• W2516488001 date "2016-08-24" @default.
• W2516488001 modified "2023-10-12" @default.
• W2516488001 title "Evolution of the Twist Subfamily Vertebrate Proteins: Discovery of a Signature Motif and Origin of the Twist1 Glycine-Rich Motifs in the Amino-Terminus Disordered Domain" @default.
• W2516488001 cites W1524025768 @default.
• W2516488001 cites W1669146528 @default.
• W2516488001 cites W1823905903 @default.
• W2516488001 cites W1922639853 @default.
• W2516488001 cites W1940463779 @default.
• W2516488001 cites W1965716280 @default.
• W2516488001 cites W1966570578 @default.
• W2516488001 cites W1970265228 @default.
• W2516488001 cites W1973354049 @default.
• W2516488001 cites W1973416922 @default.
• W2516488001 cites W1981106225 @default.
• W2516488001 cites W1983019887 @default.
• W2516488001 cites W1983231547 @default.
• W2516488001 cites W1990207722 @default.
• W2516488001 cites W1998918975 @default.
• W2516488001 cites W2004377868 @default.
• W2516488001 cites W2016170088 @default.
• W2516488001 cites W2027824503 @default.
• W2516488001 cites W2029176324 @default.
• W2516488001 cites W2029537439 @default.
• W2516488001 cites W2031297102 @default.
• W2516488001 cites W2052658057 @default.
• W2516488001 cites W2055043387 @default.
• W2516488001 cites W2060259273 @default.
• W2516488001 cites W2072989962 @default.
• W2516488001 cites W2073745520 @default.
• W2516488001 cites W2074149867 @default.
• W2516488001 cites W2075328770 @default.
• W2516488001 cites W2081680313 @default.
• W2516488001 cites W2082604468 @default.
• W2516488001 cites W2085656056 @default.
• W2516488001 cites W2086441524 @default.
• W2516488001 cites W2089333424 @default.
• W2516488001 cites W2107097650 @default.
• W2516488001 cites W2107158607 @default.
• W2516488001 cites W2111303992 @default.
• W2516488001 cites W2115888213 @default.
• W2516488001 cites W2117484859 @default.
• W2516488001 cites W2119693327 @default.
• W2516488001 cites W2120734105 @default.
• W2516488001 cites W2123927702 @default.
• W2516488001 cites W2125022522 @default.
• W2516488001 cites W2133014215 @default.
• W2516488001 cites W2135749238 @default.
• W2516488001 cites W2136216033 @default.
• W2516488001 cites W2137991504 @default.
• W2516488001 cites W2141791765 @default.
• W2516488001 cites W2142872318 @default.
• W2516488001 cites W2148487263 @default.
• W2516488001 cites W2149286566 @default.
• W2516488001 cites W2152688507 @default.
• W2516488001 cites W2159957100 @default.
• W2516488001 cites W2160378721 @default.
• W2516488001 cites W2161320035 @default.
• W2516488001 cites W2169890434 @default.
• W2516488001 cites W2472378828 @default.
• W2516488001 cites W4210968583 @default.
• W2516488001 cites W83012740 @default.
• W2516488001 doi "https://doi.org/10.1371/journal.pone.0161029" @default.
• W2516488001 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5061384" @default.
• W2516488001 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27732679" @default.
• W2516488001 hasPublicationYear "2016" @default.
• W2516488001 type Work @default.
• W2516488001 sameAs 2516488001 @default.
• W2516488001 citedByCount "11" @default.
• W2516488001 countsByYear W25164880012016 @default.
• W2516488001 countsByYear W25164880012018 @default.
• W2516488001 countsByYear W25164880012019 @default.
• W2516488001 countsByYear W25164880012021 @default.
• W2516488001 countsByYear W25164880012022 @default.
• W2516488001 countsByYear W25164880012023 @default.
• W2516488001 crossrefType "journal-article" @default.
• W2516488001 hasAuthorship W2516488001A5059857304 @default.
• W2516488001 hasAuthorship W2516488001A5060968798 @default.
• W2516488001 hasAuthorship W2516488001A5064736805 @default.
• W2516488001 hasBestOaLocation W25164880011 @default.
• W2516488001 hasConcept C104317684 @default.
• W2516488001 hasConcept C117745874 @default.
• W2516488001 hasConcept C132677234 @default.
• W2516488001 hasConcept C144292202 @default.
• W2516488001 hasConcept C167625842 @default.
• W2516488001 hasConcept C171897839 @default.
• W2516488001 hasConcept C193252679 @default.
• W2516488001 hasConcept C199216141 @default.
• W2516488001 hasConcept C2778961482 @default.
• W2516488001 hasConcept C45484198 @default.
• W2516488001 hasConcept C47701112 @default.
• W2516488001 hasConcept C50929876 @default.
• W2516488001 hasConcept C515207424 @default.
• W2516488001 hasConcept C54355233 @default.

• next