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- W2516492722 abstract "Objectives To compare neuronal firing rates from the Globus Pallidus interna (GPi) and externa (GPe) in children undergoing DBS for different types of dystonia and to relate findings to outcome. Methods Microelectrode data were obtained to guide electrode position in 44 children with dystonia (14 Primary, 22 Secondary Static, 8 Secondary Progressive due to Neurodegeneration and Brain Iron Accumulation (NBIA); age 3.3–18.1 years). Digitised spike trains were analysed off-line, blind to clinical data. Results We identified 267 GPi and 87 GPe cells. Median GPi firing frequency was higher in Primary (13.5 Hz) than Secondary Static dystonia (9.6 Hz) ( p = 0.002) and higher in NBIA (25 Hz) than either Primary ( p = 0.006) or Secondary Static dystonia ( p = 0.00004). Median GPe firing frequency was higher in NBIA (15.9 Hz) than Secondary Static dystonia (7 Hz) ( p = 0.013). The proportion of regular versus irregularly firing cells also varied significantly across groups ( p p = 0.040) and particularly for the non-progressive patients ( p = 0.006). Conclusion Pallidal firing rates differ with dystonia type and correlate with DBS outcome. This information could guide future target selection in a more individualized approach to neuromodulation." @default.
- W2516492722 created "2016-09-16" @default.
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- W2516492722 date "2016-03-01" @default.
- W2516492722 modified "2023-09-27" @default.
- W2516492722 title "Globus pallidus neuronal firing rates relate to dystonia aetiology and outcome from Deep Brain Stimulation (DBS) in children" @default.
- W2516492722 doi "https://doi.org/10.1016/j.clinph.2015.11.124" @default.
- W2516492722 hasPublicationYear "2016" @default.
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