FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2516541128> ?p ?o ?g. }

• W2516541128 endingPage "e0161926" @default.
• W2516541128 startingPage "e0161926" @default.
• W2516541128 abstract "Whole genome sequencing and analyses of Ureaplasma diversum ATCC 49782 was undertaken as a step towards understanding U. diversum biology and pathogenicity. The complete genome showed 973,501 bp in a single circular chromosome, with 28.2% of G+C content. A total of 782 coding DNA sequences (CDSs), and 6 rRNA and 32 tRNA genes were predicted and annotated. The metabolic pathways are identical to other human ureaplasmas, including the production of ATP via hydrolysis of the urea. Genes related to pathogenicity, such as urease, phospholipase, hemolysin, and a Mycoplasma Ig binding protein (MIB)-Mycoplasma Ig protease (MIP) system were identified. More interestingly, a large number of genes (n = 40) encoding surface molecules were annotated in the genome (lipoproteins, multiple-banded antigen like protein, membrane nuclease lipoprotein and variable surface antigens lipoprotein). In addition, a gene encoding glycosyltransferase was also found. This enzyme has been associated with the production of capsule in mycoplasmas and ureaplasma. We then sought to detect the presence of a capsule in this organism. A polysaccharide capsule from 11 to 17 nm of U. diversum was observed trough electron microscopy and using specific dyes. This structure contained arabinose, xylose, mannose, galactose and glucose. In order to understand the inflammatory response against these surface molecules, we evaluated the response of murine macrophages J774 against viable and non-viable U. diversum. As with viable bacteria, non-viable bacteria were capable of promoting a significant inflammatory response by activation of Toll like receptor 2 (TLR2), indicating that surface molecules are important for the activation of inflammatory response. Furthermore, a cascade of genes related to the inflammasome pathway of macrophages was also up-regulated during infection with viable organisms when compared to non-infected cells. In conclusion, U. diversum has a typical ureaplasma genome and metabolism, and its surface molecules, including the identified capsular material, represent major components of the organism immunopathogenesis." @default.
• W2516541128 created "2016-09-16" @default.
• W2516541128 creator A5000569088 @default.
• W2516541128 creator A5009807180 @default.
• W2516541128 creator A5018555525 @default.
• W2516541128 creator A5031781033 @default.
• W2516541128 creator A5033120586 @default.
• W2516541128 creator A5035503672 @default.
• W2516541128 creator A5044241083 @default.
• W2516541128 creator A5046824665 @default.
• W2516541128 creator A5051351483 @default.
• W2516541128 creator A5054795368 @default.
• W2516541128 creator A5056771688 @default.
• W2516541128 creator A5058776961 @default.
• W2516541128 creator A5064685546 @default.
• W2516541128 creator A5067898614 @default.
• W2516541128 creator A5070936165 @default.
• W2516541128 creator A5074801042 @default.
• W2516541128 creator A5085426668 @default.
• W2516541128 creator A5088796122 @default.
• W2516541128 creator A5091261084 @default.
• W2516541128 date "2016-09-07" @default.
• W2516541128 modified "2023-10-12" @default.
• W2516541128 title "Ureaplasma diversum Genome Provides New Insights about the Interaction of the Surface Molecules of This Bacterium with the Host" @default.
• W2516541128 cites W129483469 @default.
• W2516541128 cites W131986677 @default.
• W2516541128 cites W1485061158 @default.
• W2516541128 cites W1543305843 @default.
• W2516541128 cites W1557267727 @default.
• W2516541128 cites W157154501 @default.
• W2516541128 cites W1591079287 @default.
• W2516541128 cites W1606763929 @default.
• W2516541128 cites W1627863859 @default.
• W2516541128 cites W1662190871 @default.
• W2516541128 cites W1691257023 @default.
• W2516541128 cites W1809721560 @default.
• W2516541128 cites W1827312519 @default.
• W2516541128 cites W1863090314 @default.
• W2516541128 cites W1894139727 @default.
• W2516541128 cites W1930428284 @default.
• W2516541128 cites W1935212338 @default.
• W2516541128 cites W1952042246 @default.
• W2516541128 cites W1961138835 @default.
• W2516541128 cites W1961523214 @default.
• W2516541128 cites W1964479231 @default.
• W2516541128 cites W1969177042 @default.
• W2516541128 cites W1978729875 @default.
• W2516541128 cites W1981238709 @default.
• W2516541128 cites W1981258085 @default.
• W2516541128 cites W1985518641 @default.
• W2516541128 cites W1990063572 @default.
• W2516541128 cites W1992685494 @default.
• W2516541128 cites W1996423252 @default.
• W2516541128 cites W2004018150 @default.
• W2516541128 cites W2005364961 @default.
• W2516541128 cites W2010913746 @default.
• W2516541128 cites W2013414094 @default.
• W2516541128 cites W2019594697 @default.
• W2516541128 cites W2037233339 @default.
• W2516541128 cites W2038159324 @default.
• W2516541128 cites W2044726854 @default.
• W2516541128 cites W2050950894 @default.
• W2516541128 cites W2055340750 @default.
• W2516541128 cites W2056335097 @default.
• W2516541128 cites W2064093933 @default.
• W2516541128 cites W2068333798 @default.
• W2516541128 cites W2070230521 @default.
• W2516541128 cites W2071153998 @default.
• W2516541128 cites W2078969200 @default.
• W2516541128 cites W2080361131 @default.
• W2516541128 cites W2085013260 @default.
• W2516541128 cites W2087365863 @default.
• W2516541128 cites W2087781281 @default.
• W2516541128 cites W2092611193 @default.
• W2516541128 cites W2095825788 @default.
• W2516541128 cites W2097706568 @default.
• W2516541128 cites W2099911577 @default.
• W2516541128 cites W2099927731 @default.
• W2516541128 cites W2100380298 @default.
• W2516541128 cites W2103826176 @default.
• W2516541128 cites W2106458129 @default.
• W2516541128 cites W2108422303 @default.
• W2516541128 cites W2113993968 @default.
• W2516541128 cites W2116391539 @default.
• W2516541128 cites W2120711580 @default.
• W2516541128 cites W2121703775 @default.
• W2516541128 cites W2122550385 @default.
• W2516541128 cites W2128656073 @default.
• W2516541128 cites W2128892592 @default.
• W2516541128 cites W2130449683 @default.
• W2516541128 cites W2131778683 @default.
• W2516541128 cites W2132099146 @default.
• W2516541128 cites W2133426017 @default.
• W2516541128 cites W2133800748 @default.
• W2516541128 cites W2138569764 @default.
• W2516541128 cites W2143485490 @default.
• W2516541128 cites W2145803213 @default.
• W2516541128 cites W2149429041 @default.

• next