FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2516586611> ?p ?o ?g. }

• W2516586611 endingPage "230" @default.
• W2516586611 startingPage "221" @default.
• W2516586611 abstract "Therapeutic exposure to high doses of radiation can severely impair organ function due to ablation of stem cells. Normal tissue injury is a dose-limiting toxicity for radiation therapy (RT). Although advances in the delivery of high-precision conformal RT has increased normal tissue sparing, mitigating and therapeutic strategies that could alleviate early and chronic radiation effects are urgently needed in order to deliver curative doses of RT, especially in abdominal, pelvic, and thoracic malignancies. Radiation-induced gastrointestinal injury is also a major cause of lethality from accidental or intentional exposure to whole-body irradiation in the case of nuclear accidents or terrorism. This review examines the therapeutic options for mitigation of non-hematopoietic radiation injuries. We have developed stem cell-based therapies for the mitigation of acute radiation syndrome and radiation-induced gastrointestinal syndrome. This is a promising option because of the robustness of standardized isolation and transplantation of stromal cell protocols, and their ability to support and replace radiation-damaged stem cells and stem cell niche. Stromal progenitor cells (SPC) represent a unique multipotent and heterogeneous cell population with regenerative, immunosuppressive, anti-inflammatory, and wound-healing properties. SPC are also known to secrete various key cytokines and growth factors such as platelet-derived growth factors, keratinocyte growth factor, R-spondins, and may consequently exert their regenerative effects via paracrine function. Additionally, secretory vesicles such as exosomes or microparticles can potentially be a cell-free alternative replacing the cell transplant in some cases. This review highlights the beneficial effects of SPC on tissue regeneration with their ability to (a) target the irradiated tissues, (b) recruit host stromal cells, (c) regenerate endothelium and epithelium, (d) and secrete regenerative and immunomodulatory paracrine signals to control inflammation, ulceration, wound healing, and fibrosis." @default.
• W2516586611 created "2016-09-16" @default.
• W2516586611 creator A5034242696 @default.
• W2516586611 creator A5036020772 @default.
• W2516586611 creator A5055510159 @default.
• W2516586611 date "2016-09-07" @default.
• W2516586611 modified "2023-09-26" @default.
• W2516586611 title "Stromal Progenitor Cells in Mitigation of Non-hematopoietic Radiation Injuries" @default.
• W2516586611 cites W1493614585 @default.
• W2516586611 cites W1791828066 @default.
• W2516586611 cites W1965547342 @default.
• W2516586611 cites W1971314603 @default.
• W2516586611 cites W1972340608 @default.
• W2516586611 cites W1978869139 @default.
• W2516586611 cites W1982603620 @default.
• W2516586611 cites W1987528768 @default.
• W2516586611 cites W1993640536 @default.
• W2516586611 cites W1994075616 @default.
• W2516586611 cites W1994216131 @default.
• W2516586611 cites W1996482730 @default.
• W2516586611 cites W1997424290 @default.
• W2516586611 cites W1999755482 @default.
• W2516586611 cites W2002386116 @default.
• W2516586611 cites W2003299661 @default.
• W2516586611 cites W2007680735 @default.
• W2516586611 cites W2011921502 @default.
• W2516586611 cites W2013817848 @default.
• W2516586611 cites W2016899305 @default.
• W2516586611 cites W2017218715 @default.
• W2516586611 cites W2017828716 @default.
• W2516586611 cites W2022915249 @default.
• W2516586611 cites W2041294219 @default.
• W2516586611 cites W2044351980 @default.
• W2516586611 cites W2046237540 @default.
• W2516586611 cites W2049108649 @default.
• W2516586611 cites W2051378737 @default.
• W2516586611 cites W2061607163 @default.
• W2516586611 cites W2066426973 @default.
• W2516586611 cites W2069028561 @default.
• W2516586611 cites W2077123113 @default.
• W2516586611 cites W2088109716 @default.
• W2516586611 cites W2089736989 @default.
• W2516586611 cites W2092001441 @default.
• W2516586611 cites W2113774857 @default.
• W2516586611 cites W2118943250 @default.
• W2516586611 cites W2119770129 @default.
• W2516586611 cites W2120307675 @default.
• W2516586611 cites W2123771262 @default.
• W2516586611 cites W2126762891 @default.
• W2516586611 cites W2129477690 @default.
• W2516586611 cites W2142765996 @default.
• W2516586611 cites W2146629016 @default.
• W2516586611 cites W2152944453 @default.
• W2516586611 cites W2154146648 @default.
• W2516586611 cites W2155614329 @default.
• W2516586611 cites W2175253011 @default.
• W2516586611 cites W2206448027 @default.
• W2516586611 cites W2271519897 @default.
• W2516586611 cites W2317447792 @default.
• W2516586611 cites W2400660038 @default.
• W2516586611 cites W2410910200 @default.
• W2516586611 cites W64319318 @default.
• W2516586611 doi "https://doi.org/10.1007/s40139-016-0114-6" @default.
• W2516586611 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5409531" @default.
• W2516586611 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/28462013" @default.
• W2516586611 hasPublicationYear "2016" @default.
• W2516586611 type Work @default.
• W2516586611 sameAs 2516586611 @default.
• W2516586611 citedByCount "5" @default.
• W2516586611 countsByYear W25165866112019 @default.
• W2516586611 countsByYear W25165866112020 @default.
• W2516586611 countsByYear W25165866112021 @default.
• W2516586611 crossrefType "journal-article" @default.
• W2516586611 hasAuthorship W2516586611A5034242696 @default.
• W2516586611 hasAuthorship W2516586611A5036020772 @default.
• W2516586611 hasAuthorship W2516586611A5055510159 @default.
• W2516586611 hasBestOaLocation W25165866112 @default.
• W2516586611 hasConcept C109159458 @default.
• W2516586611 hasConcept C126322002 @default.
• W2516586611 hasConcept C142724271 @default.
• W2516586611 hasConcept C151872237 @default.
• W2516586611 hasConcept C16930146 @default.
• W2516586611 hasConcept C170493617 @default.
• W2516586611 hasConcept C171056886 @default.
• W2516586611 hasConcept C18903297 @default.
• W2516586611 hasConcept C198826908 @default.
• W2516586611 hasConcept C201750760 @default.
• W2516586611 hasConcept C203014093 @default.
• W2516586611 hasConcept C2780007613 @default.
• W2516586611 hasConcept C28328180 @default.
• W2516586611 hasConcept C2908647359 @default.
• W2516586611 hasConcept C502942594 @default.
• W2516586611 hasConcept C71924100 @default.
• W2516586611 hasConcept C7876069 @default.
• W2516586611 hasConcept C86803240 @default.
• W2516586611 hasConcept C95444343 @default.
• W2516586611 hasConcept C99454951 @default.
• W2516586611 hasConceptScore W2516586611C109159458 @default.

• next