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• W2516672017 abstract "The design of randomized controlled clinical studies can greatly benefit from iterative assessments of population representativeness of eligibility criteria. We propose a multi-trait metric - GIST 2.0 that can compute the a priori generalizability based on the population representativeness of a clinical study by explicitly modeling the dependencies among all eligibility criteria. We evaluate this metric on twenty clinical studies of two diseases and analyze how a study's eligibility criteria affect its generalizability (collectively and individually). We statistically analyze the effects of trial setting, trait selection and trait summarizing technique on GIST 2.0. Finally we provide theoretical as well as empirical validations for the expected properties of GIST 2.0." @default.
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• W2516672017 date "2016-10-01" @default.
• W2516672017 modified "2023-10-04" @default.
• W2516672017 title "GIST 2.0: A scalable multi-trait metric for quantifying population representativeness of individual clinical studies" @default.
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• W2516672017 doi "https://doi.org/10.1016/j.jbi.2016.09.003" @default.
• W2516672017 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5077682" @default.
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