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• W2516695993 abstract "Plants possess intracellular immune receptors designated nucleotide-binding domain and leucine-rich repeat (NLR) proteins that translate pathogen-specific recognition into disease-resistance signaling. The wheat immune receptors Sr33 and Sr50 belong to the class of coiled-coil (CC) NLRs. They confer resistance against a broad spectrum of field isolates of Puccinia graminis f. sp. tritici, including the Ug99 lineage, and are homologs of the barley powdery mildew-resistance protein MLA10. Here, we show that, similarly to MLA10, the Sr33 and Sr50 CC domains are sufficient to induce cell death in Nicotiana benthamiana Autoactive CC domains and full-length Sr33 and Sr50 proteins self-associate in planta In contrast, truncated CC domains equivalent in size to an MLA10 fragment for which a crystal structure was previously determined fail to induce cell death and do not self-associate. Mutations in the truncated region also abolish self-association and cell-death signaling. Analysis of Sr33 and Sr50 CC domains fused to YFP and either nuclear localization or nuclear export signals in N benthamiana showed that cell-death induction occurs in the cytosol. In stable transgenic wheat plants, full-length Sr33 proteins targeted to the cytosol provided rust resistance, whereas nuclear-targeted Sr33 was not functional. These data are consistent with CC-mediated induction of both cell-death signaling and stem rust resistance in the cytosolic compartment, whereas previous research had suggested that MLA10-mediated cell-death and disease resistance signaling occur independently, in the cytosol and nucleus, respectively." @default.
• W2516695993 created "2016-09-16" @default.
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• W2516695993 date "2016-08-23" @default.
• W2516695993 modified "2023-10-14" @default.
• W2516695993 title "Cytosolic activation of cell death and stem rust resistance by cereal MLA-family CC–NLR proteins" @default.
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• W2516695993 cites W1974182935 @default.
• W2516695993 cites W1981932072 @default.
• W2516695993 cites W1985835804 @default.
• W2516695993 cites W1987526931 @default.
• W2516695993 cites W1996735891 @default.
• W2516695993 cites W1999214874 @default.
• W2516695993 cites W2001845502 @default.
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• W2516695993 cites W2007855110 @default.
• W2516695993 cites W2008421769 @default.
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• W2516695993 cites W2010854320 @default.
• W2516695993 cites W2018806611 @default.
• W2516695993 cites W2021408028 @default.
• W2516695993 cites W2022549989 @default.
• W2516695993 cites W2024645073 @default.
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• W2516695993 cites W2116439866 @default.
• W2516695993 cites W2121429996 @default.
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• W2516695993 doi "https://doi.org/10.1073/pnas.1605483113" @default.
• W2516695993 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5018743" @default.
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• W2516695993 hasPublicationYear "2016" @default.
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