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• W2516848655 abstract "Event Abstract Back to Event Characterization of striatal afferents by monosynaptic retrograde tracing Amandine Cornil1*, Alban De Kerchove D'Exaerde1 and Serge N. Schiffmann1 1 laboratoire de neurophysiologie. ULB, Belgium The basal ganglia system is composed of a set of subcortical nuclei mainly involved in the control and motor learning, but also in the reward system as well as emotions. Various neurodegenerative diseases lead to a dysfunction of this system. The largest and entry nucleus in the basal ganglia is the striatum. All striatal projection neurons are inhibitory GABAergic neurons, known as medium spiny neurons (MSNs). They are divided into two subtypes, striatopallidal and striatonigral neurons. These two neuronal populations can be targeted using transgenic mouse lines expressing Cre-recombinase in 2 types of striatal neurons (respectively A2A-Cre and D1-Cre). From a functional point of view, the striatum may be divided into a ventral and a dorsal portion. The first is mainly involved in motivational and rewarding processes as well as drug addiction. The latter is more implicated in the control of locomotor activity and habits learning. The dorsal striatum can be divided into an outer portion called dorsolateral striatum (DLS) and an inner portion, dorsomedial striatum (DMS). Here we used a combinatorial viral approach with engineered rabies virus glycoproteins to monosynaptically highlight the afferents to these neurons in regard of striatal subdivisions. Résumé en Français: Le système des neurones appelés ganglions de la base est principalement impliqué dans le contrôle et l'apprentissage moteur mais également dans le système de la récompense et des émotions. De nombreuses maladies neurodégénératives entrainent un dysfonctionnement de ce système. La structure d’entrée la plus importante de ce système des noyaux de la base est le striatum. Par l’utilisation d’une approche virale utilisant des virus de la rage modifiés, il a été possible de mettre en évidence les afférences (entées) au striatum provenant du thalamus et du cortex en fonction des subdivisions du striatum. Samenvatting in het Nederlands : Het neuronensysteem genaamd basale glangia(of basale kernen) is vooral betrokken bij de controle en het aanleren van de motoriek maar eveneens bij emoties en beloning. Verschillende neurodegeneratieve aandoeningen vervlakken dit systeem. De belangrijkste input van deze basale kernen vindt plaats via het striatium. Door gebruik te maken van een virale aanpak waarbij het rabiësvirus (rabiës = hondsdolheid) gebezigd wordt, is het mogelijk de betrokkenheid van het striatum in dit inputsysteem, vanuit de thalamus en de hersenschors, te markeren in functie van de onderverdelingen van het striatum (het striatum is opgebouwd uit verschillende delen). Keywords: Striatum, tracing, Rabies virus, Neuroanatomy, neural circuits, Medium Spiny Neuron Conference: 6th Belgian Brain Congress, MONS, Belgium, 8 Oct - 8 Oct, 2016. Presentation Type: Poster Presentation Topic: Brain and brain diseases: between heredity and environment Citation: Cornil A, De Kerchove D'Exaerde A and Schiffmann SN (2016). Characterization of striatal afferents by monosynaptic retrograde tracing. Conference Abstract: 6th Belgian Brain Congress. doi: 10.3389/conf.fnagi.2016.03.00065 Copyright: The abstracts in this collection have not been subject to any Frontiers peer review or checks, and are not endorsed by Frontiers. They are made available through the Frontiers publishing platform as a service to conference organizers and presenters. The copyright in the individual abstracts is owned by the author of each abstract or his/her employer unless otherwise stated. Each abstract, as well as the collection of abstracts, are published under a Creative Commons CC-BY 4.0 (attribution) licence (https://creativecommons.org/licenses/by/4.0/) and may thus be reproduced, translated, adapted and be the subject of derivative works provided the authors and Frontiers are attributed. For Frontiers’ terms and conditions please see https://www.frontiersin.org/legal/terms-and-conditions. Received: 27 Jun 2016; Published Online: 13 Jul 2016. * Correspondence: PhD. Amandine Cornil, laboratoire de neurophysiologie. ULB, Bruxelles, 1070, Belgium, amandinecornil@gmail.com Login Required This action requires you to be registered with Frontiers and logged in. To register or login click here. Abstract Info Abstract The Authors in Frontiers Amandine Cornil Alban De Kerchove D'Exaerde Serge N Schiffmann Google Amandine Cornil Alban De Kerchove D'Exaerde Serge N Schiffmann Google Scholar Amandine Cornil Alban De Kerchove D'Exaerde Serge N Schiffmann PubMed Amandine Cornil Alban De Kerchove D'Exaerde Serge N Schiffmann Related Article in Frontiers Google Scholar PubMed Abstract Close Back to top Javascript is disabled. Please enable Javascript in your browser settings in order to see all the content on this page." @default.
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• W2516848655 title "Characterization of striatal afferents by monosynaptic retrograde tracing" @default.
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