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- W2516969557 abstract "The extension in human lifespan in the last century results in a significant increase in incidence of age related diseases. It is therefore crucial to identify key factors that control elderly healthspan. Similar to dietary restriction, mice overexpressing the NAD+ dependent protein deacylase SIRT6 (MOSES) live longer and have reduced IGF-1 levels. However, it is as yet unknown whether SIRT6 also affects various healthspan parameters. Here, a range of age related phenotypes was evaluated in MOSES mice. In comparison to their wild-type (WT) littermates, old MOSES mice showed amelioration of a variety of age-related disorders, including: improved glucose tolerance, younger hormonal profile, reduced age-related adipose inflammation and increased physical activity. The increased activity was accompanied with increased muscle AMP-activated protein kinase (AMPK) activity. Altogether, these results indicate that overexpression of SIRT6 in mice retards important aspects of the aging process and suggest SIRT6 to be a potential therapeutic target for the treatment of a set of age-related disorders." @default.
- W2516969557 created "2016-09-16" @default.
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- W2516969557 date "2016-08-12" @default.
- W2516969557 modified "2023-10-12" @default.
- W2516969557 title "SIRT6 Overexpression Improves Various Aspects of Mouse Healthspan" @default.
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- W2516969557 cites W1935070596 @default.
- W2516969557 cites W1966755977 @default.
- W2516969557 cites W1972924731 @default.
- W2516969557 cites W1973901371 @default.
- W2516969557 cites W1980018325 @default.
- W2516969557 cites W1980835609 @default.
- W2516969557 cites W1982795254 @default.
- W2516969557 cites W1985308585 @default.
- W2516969557 cites W1986760556 @default.
- W2516969557 cites W1991245151 @default.
- W2516969557 cites W1994540097 @default.
- W2516969557 cites W1995217137 @default.
- W2516969557 cites W1997145913 @default.
- W2516969557 cites W2004399750 @default.
- W2516969557 cites W2006690685 @default.
- W2516969557 cites W2014287442 @default.
- W2516969557 cites W2016656923 @default.
- W2516969557 cites W2019755675 @default.
- W2516969557 cites W2020311873 @default.
- W2516969557 cites W2021264577 @default.
- W2516969557 cites W2021469756 @default.
- W2516969557 cites W2023912026 @default.
- W2516969557 cites W2023923918 @default.
- W2516969557 cites W2024434945 @default.
- W2516969557 cites W2025668535 @default.
- W2516969557 cites W2026102269 @default.
- W2516969557 cites W2027106329 @default.
- W2516969557 cites W2042716686 @default.
- W2516969557 cites W2045694545 @default.
- W2516969557 cites W2054866841 @default.
- W2516969557 cites W2062192973 @default.
- W2516969557 cites W2069049877 @default.
- W2516969557 cites W2073175998 @default.
- W2516969557 cites W2073244138 @default.
- W2516969557 cites W2074974899 @default.
- W2516969557 cites W2079179318 @default.
- W2516969557 cites W2080094749 @default.
- W2516969557 cites W2087759495 @default.
- W2516969557 cites W2094714976 @default.
- W2516969557 cites W2097363242 @default.
- W2516969557 cites W2102150703 @default.
- W2516969557 cites W2104438296 @default.
- W2516969557 cites W2105573142 @default.
- W2516969557 cites W2122073743 @default.
- W2516969557 cites W2125257974 @default.
- W2516969557 cites W2126525177 @default.
- W2516969557 cites W2128402823 @default.
- W2516969557 cites W2129155846 @default.
- W2516969557 cites W2130410032 @default.
- W2516969557 cites W2130909039 @default.
- W2516969557 cites W2131039312 @default.
- W2516969557 cites W2131250713 @default.
- W2516969557 cites W2139449514 @default.
- W2516969557 cites W2140323371 @default.
- W2516969557 cites W2141091098 @default.
- W2516969557 cites W2143049294 @default.
- W2516969557 cites W2145540652 @default.
- W2516969557 cites W2152377123 @default.
- W2516969557 cites W2156934560 @default.
- W2516969557 cites W2157649587 @default.
- W2516969557 cites W2158092222 @default.
- W2516969557 cites W2159974907 @default.
- W2516969557 cites W2164361361 @default.
- W2516969557 cites W2165678812 @default.
- W2516969557 cites W2171748049 @default.
- W2516969557 cites W2174684589 @default.
- W2516969557 cites W2234950399 @default.
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- W2516969557 cites W2770839523 @default.
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- W2516969557 doi "https://doi.org/10.1093/gerona/glw152" @default.
- W2516969557 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27519885" @default.
- W2516969557 hasPublicationYear "2016" @default.
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