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• W2517165807 abstract "To assess associations between HbA1c and progression of coronary artery calcification (CAC) in persons with and without diabetes. In the Heinz Nixdorf Recall Study, a population-based cohort study in Germany (N = 3453, aged 45–74 years), CAC was assessed by electron-beam tomography at baseline and at 5-year follow-up. At baseline, participants were divided into five groups: poorly (HbA1c ≥ 7.0%) and well (HbA1c < 7.0%) controlled previously known diabetes (group I/II); no previously known diabetes with HbA1c ≥ 6.5% (group III), HbA1c 5.7–6.4% (group IV), and HbA1c < 5.7% (group V). We fitted linear, logistic and robust Poisson regression models to assess associations between diabetes group and PF5 (factor by which CAC after 5-year follow-up is larger than baseline CAC), and categories of CAC change, respectively. Relative to group V, adjusted percentage increase of the geometric mean of PF5 (95% CI) was: 69.1% (33.9%;113.6%), 15.4% (− 5.6%;41.1%), − 4.1% (− 22.2%;18.2%), 4.2% (− 5.4%;14.8%) for groups I–IV, respectively. The corresponding odds ratios for annual CAC increase ≥ 100 Agatston units (reference: < 10) were 10.0 (4.8;20.6), 4.0 (2.1;7.6), 1.5 (0.7;3.2), and 1.1 (0.7;1.8). In known diabetes, CAC progression was stronger in poor diabetes control. For newly detected diabetes diagnosed by HbA1c ≥ 6.5%, associations with CAC progression were weak." @default.
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• W2517165807 date "2017-01-01" @default.
• W2517165807 modified "2023-09-28" @default.
• W2517165807 title "Progression of coronary artery calcification is stronger in poorly than in well controlled diabetes: Results from the Heinz Nixdorf Recall Study" @default.
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• W2517165807 doi "https://doi.org/10.1016/j.jdiacomp.2016.08.011" @default.
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