FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2517297211> ?p ?o ?g. }

• W2517297211 endingPage "56" @default.
• W2517297211 startingPage "46" @default.
• W2517297211 abstract "Hypo- and hyperthyroid states, as well as functional abnormalities in the hypothalamic-pituitary-thyroid axis have been associated with psychiatric conditions like anxiety and depression. However, the nature of this relationship is poorly understood since it is difficult to ascertain the thyroid status of the brain in humans. Data from animal models indicate that the brain exhibits efficient homeostatic mechanisms that maintain local levels of the active thyroid hormone, triiodothyronine (T3) within a narrow range. To better understand the consequences of peripheral and central thyroid status for mood-related behaviors, we used a mouse model of type 3 deiodinase (DIO3) deficiency (Dio3 -/- mouse). This enzyme inactivates thyroid hormone and is highly expressed in the adult central nervous system. Adult Dio3 -/- mice exhibit elevated levels of T3-dependent gene expression in the brain, despite peripheral hypothyroidism as indicated by low circulating levels of thyroxine and T3. Dio3 -/- mice of both sexes exhibit hyperactivity and significantly decreased anxiety-like behavior, as measured by longer time spent in the open arms of the elevated plus maze and in the light area of the light/dark box. During the tail suspension, they stayed immobile for a significantly shorter time than their wild-type littermates, suggesting decreased depression-like behavior. These results indicate that increased thyroid hormone in the brain, not necessarily in peripheral tissues, correlates with hyperactivity and with decreases in anxiety and depression-like behaviors. Our results also underscore the importance of DIO3 as a determinant of behavior by locally regulating the brain levels of thyroid hormone." @default.
• W2517297211 created "2016-09-16" @default.
• W2517297211 creator A5025755871 @default.
• W2517297211 creator A5030192169 @default.
• W2517297211 creator A5052406385 @default.
• W2517297211 date "2016-12-01" @default.
• W2517297211 modified "2023-09-30" @default.
• W2517297211 title "Decreased anxiety- and depression-like behaviors and hyperactivity in a type 3 deiodinase-deficient mouse showing brain thyrotoxicosis and peripheral hypothyroidism" @default.
• W2517297211 cites W1516263550 @default.
• W2517297211 cites W1722766836 @default.
• W2517297211 cites W1900867665 @default.
• W2517297211 cites W1966744758 @default.
• W2517297211 cites W1966895214 @default.
• W2517297211 cites W1972385615 @default.
• W2517297211 cites W1975711757 @default.
• W2517297211 cites W1976816826 @default.
• W2517297211 cites W1978457136 @default.
• W2517297211 cites W1978960933 @default.
• W2517297211 cites W1980185058 @default.
• W2517297211 cites W1981076591 @default.
• W2517297211 cites W1983139854 @default.
• W2517297211 cites W1984376871 @default.
• W2517297211 cites W1984748289 @default.
• W2517297211 cites W1984784098 @default.
• W2517297211 cites W1986224284 @default.
• W2517297211 cites W1994845177 @default.
• W2517297211 cites W1997376959 @default.
• W2517297211 cites W1997852508 @default.
• W2517297211 cites W2003795436 @default.
• W2517297211 cites W2003958296 @default.
• W2517297211 cites W2003982930 @default.
• W2517297211 cites W2012173637 @default.
• W2517297211 cites W2018421710 @default.
• W2517297211 cites W2020027766 @default.
• W2517297211 cites W2022499635 @default.
• W2517297211 cites W2023059234 @default.
• W2517297211 cites W2023463989 @default.
• W2517297211 cites W2026234549 @default.
• W2517297211 cites W2028506700 @default.
• W2517297211 cites W2030111883 @default.
• W2517297211 cites W2030299359 @default.
• W2517297211 cites W2032988342 @default.
• W2517297211 cites W2036110060 @default.
• W2517297211 cites W2038964583 @default.
• W2517297211 cites W2041767992 @default.
• W2517297211 cites W2042645039 @default.
• W2517297211 cites W2043548753 @default.
• W2517297211 cites W2045165986 @default.
• W2517297211 cites W2046186891 @default.
• W2517297211 cites W2048983470 @default.
• W2517297211 cites W2049813666 @default.
• W2517297211 cites W2053714798 @default.
• W2517297211 cites W2055276225 @default.
• W2517297211 cites W2055628238 @default.
• W2517297211 cites W2056276679 @default.
• W2517297211 cites W2063595480 @default.
• W2517297211 cites W2065440547 @default.
• W2517297211 cites W2068220687 @default.
• W2517297211 cites W2070802749 @default.
• W2517297211 cites W2079439953 @default.
• W2517297211 cites W2082033604 @default.
• W2517297211 cites W2083952100 @default.
• W2517297211 cites W2083961421 @default.
• W2517297211 cites W2086045896 @default.
• W2517297211 cites W2087520612 @default.
• W2517297211 cites W2089360863 @default.
• W2517297211 cites W2090877505 @default.
• W2517297211 cites W2090879071 @default.
• W2517297211 cites W2093802594 @default.
• W2517297211 cites W2094906331 @default.
• W2517297211 cites W2100826494 @default.
• W2517297211 cites W2101123075 @default.
• W2517297211 cites W2102755501 @default.
• W2517297211 cites W2102954259 @default.
• W2517297211 cites W2109053894 @default.
• W2517297211 cites W2112018308 @default.
• W2517297211 cites W2113649741 @default.
• W2517297211 cites W2117218916 @default.
• W2517297211 cites W2118393645 @default.
• W2517297211 cites W2122579597 @default.
• W2517297211 cites W2124333455 @default.
• W2517297211 cites W2126376525 @default.
• W2517297211 cites W2142658622 @default.
• W2517297211 cites W2144034070 @default.
• W2517297211 cites W2154944793 @default.
• W2517297211 cites W2165022229 @default.
• W2517297211 cites W2177906629 @default.
• W2517297211 cites W2418008442 @default.
• W2517297211 cites W2461249801 @default.
• W2517297211 cites W2471351149 @default.
• W2517297211 doi "https://doi.org/10.1016/j.psyneuen.2016.08.021" @default.
• W2517297211 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5159228" @default.
• W2517297211 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27580013" @default.
• W2517297211 hasPublicationYear "2016" @default.
• W2517297211 type Work @default.
• W2517297211 sameAs 2517297211 @default.
• W2517297211 citedByCount "29" @default.
• W2517297211 countsByYear W25172972112017 @default.

• next