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- W2517382837 abstract "Endometriosis is a painful condition characterized by growth of endometrial cysts outside the uterus. Here, we tested the hypothesis that peripheral innervation and prostaglandin levels contribute to endometriosis-associated pain. Female Sprague-Dawley rats (n = 16) were surgically instrumented by transplanting uterine tissue onto mesenteric arteries within the peritoneal cavity to create a model of endometriosis which forms extra-uterine endometrial cysts and vaginal hyperalgesia. Our results describe a significant positive correlation between endometriosis-induced vaginal hyperalgesia and cyst innervation density (sensory, r = 0.70, p = 0.003; sympathetic, r = 0.55, p = 0.03), vaginal canal sympathetic innervation density (r = 0.80, p = 0.003), and peritoneal fluid levels of the prostaglandins PGE2 (r = 0.65, p = 0.01) and PGF2α (r = 0.63, p = 0.02). These results support the involvement of cyst innervation and prostaglandins in endometriosis-associated pain. We also describe how sympathetic innervation density of the vaginal canal is an important predictor of vaginal hyperalgesia." @default.
- W2517382837 created "2016-09-16" @default.
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- W2517382837 date "2016-12-01" @default.
- W2517382837 modified "2023-10-14" @default.
- W2517382837 title "Prostaglandin levels, vaginal innervation, and cyst innervation as peripheral contributors to endometriosis-associated vaginal hyperalgesia in rodents" @default.
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- W2517382837 doi "https://doi.org/10.1016/j.mce.2016.08.017" @default.
- W2517382837 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5048574" @default.
- W2517382837 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27524411" @default.
- W2517382837 hasPublicationYear "2016" @default.
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