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- W2517399327 abstract "HCV (Hepatitis C virus) infection leads to complex liver diseases by affecting the hepatocytes. HCV Non-structural protein NS3 protease play major role in the processing of polyprotein and replication of HCV. NS5b is also a key enzyme in the replication of the virus. In our study we first selected 5 plants based on their significance in inhibiting liver disorders, viral infections and their use in treatment of viral infection. A library of 10 flavonoids were constructed and docked against NS3 protease and 5 sites of NS5B which includes active site and allosteric sites; palm site 1, palm site 2, thumb site 1, thumb site 2. quercetin 3-O- rutinoside showed the best interactions with both NS3 and 5 sites of NS5B. However, in-vitro studies have to be performed in order to confirm the inhibitory effect of these flavonoids." @default.
- W2517399327 created "2016-09-16" @default.
- W2517399327 creator A5071761955 @default.
- W2517399327 date "2016-09-25" @default.
- W2517399327 modified "2023-09-27" @default.
- W2517399327 title "COMPUTATIONAL SCREENING OF FLAVONOIDS FOR HCV INHIBITION" @default.
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- W2517399327 doi "https://doi.org/10.15623/ijret.2016.0529007" @default.
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