FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2517503832> ?p ?o ?g. }

• W2517503832 abstract "Hepatocellular carcinoma (HCC) is the third leading cause of cancer-related deaths. The average survival and 5-year survival rates of HCC patients still remains poor. Thus, there is an urgent need to better understand the mechanisms of cancer progression in HCC and to identify useful biomarkers to predict prognosis.Public data portals including Oncomine, The Cancer Genome Atlas (TCGA) and Gene Expression Omnibus (GEO) profiles were used to retrieve the HCC-related microarrays and to identify potential genes contributed to cancer progression. Bioinformatics analyses including pathway enrichment, protein/gene interaction and text mining were used to explain the potential roles of the identified genes in HCC. Quantitative real-time polymerase chain reaction analysis and Western blotting were used to measure the expression of the targets. The data were analysed by SPSS 20.0 software.We identified 80 genes that were significantly dysregulated in HCC according to four independent microarrays covering 386 cases of HCC and 327 normal liver tissues. Twenty genes were consistently and stably dysregulated in the four microarrays by at least 2-fold and detection of gene expression by RT-qPCR and western blotting showed consistent expression profiles in 11 HCC tissues compared with corresponding paracancerous tissues. Eleven of these 20 genes were associated with disease-free survival (DFS) or overall survival (OS) in a cohort of 157 HCC patients, and eight genes were associated with tumour pathologic PT, tumour stage or vital status. Potential roles of those 20 genes in regulation of HCC progression were predicted, primarily in association with metastasis. INTS8 was specifically correlated with most clinical characteristics including DFS, OS, stage, metastasis, invasiveness, diagnosis, and age.The significantly dysregulated genes identified in this study were associated with cancer progression and prognosis in HCC, and might be potential therapeutic targets for HCC treatment or potential biomarkers for diagnosis and prognosis." @default.
• W2517503832 created "2016-09-16" @default.
• W2517503832 creator A5009697908 @default.
• W2517503832 creator A5012748027 @default.
• W2517503832 creator A5016282780 @default.
• W2517503832 creator A5023103876 @default.
• W2517503832 creator A5034266315 @default.
• W2517503832 creator A5042453706 @default.
• W2517503832 creator A5053427316 @default.
• W2517503832 creator A5053892310 @default.
• W2517503832 creator A5061817335 @default.
• W2517503832 date "2016-08-27" @default.
• W2517503832 modified "2023-10-14" @default.
• W2517503832 title "Microarray-based identification of genes associated with cancer progression and prognosis in hepatocellular carcinoma" @default.
• W2517503832 cites W1169587918 @default.
• W2517503832 cites W1484632492 @default.
• W2517503832 cites W1539688055 @default.
• W2517503832 cites W1697344940 @default.
• W2517503832 cites W1802924733 @default.
• W2517503832 cites W1854013706 @default.
• W2517503832 cites W1904080989 @default.
• W2517503832 cites W1950402335 @default.
• W2517503832 cites W1964636469 @default.
• W2517503832 cites W1974070001 @default.
• W2517503832 cites W1977918192 @default.
• W2517503832 cites W1981045629 @default.
• W2517503832 cites W1981284797 @default.
• W2517503832 cites W1981849943 @default.
• W2517503832 cites W1984303873 @default.
• W2517503832 cites W1998546180 @default.
• W2517503832 cites W2004879434 @default.
• W2517503832 cites W2007601283 @default.
• W2517503832 cites W2010016726 @default.
• W2517503832 cites W2018786027 @default.
• W2517503832 cites W2019528720 @default.
• W2517503832 cites W2019691887 @default.
• W2517503832 cites W2029693465 @default.
• W2517503832 cites W2036809336 @default.
• W2517503832 cites W2041343642 @default.
• W2517503832 cites W2045252000 @default.
• W2517503832 cites W2048793404 @default.
• W2517503832 cites W2053491138 @default.
• W2517503832 cites W2058038024 @default.
• W2517503832 cites W2059683048 @default.
• W2517503832 cites W2061743943 @default.
• W2517503832 cites W2064808249 @default.
• W2517503832 cites W2067110241 @default.
• W2517503832 cites W2068321316 @default.
• W2517503832 cites W2069524579 @default.
• W2517503832 cites W2075005938 @default.
• W2517503832 cites W2077852082 @default.
• W2517503832 cites W2077871358 @default.
• W2517503832 cites W2079472457 @default.
• W2517503832 cites W2084262557 @default.
• W2517503832 cites W2086035953 @default.
• W2517503832 cites W2088953432 @default.
• W2517503832 cites W2092888413 @default.
• W2517503832 cites W2094953050 @default.
• W2517503832 cites W2095673674 @default.
• W2517503832 cites W2096525273 @default.
• W2517503832 cites W2114843025 @default.
• W2517503832 cites W2116443392 @default.
• W2517503832 cites W2116482230 @default.
• W2517503832 cites W2118258530 @default.
• W2517503832 cites W2121906867 @default.
• W2517503832 cites W2124649441 @default.
• W2517503832 cites W2133465414 @default.
• W2517503832 cites W2134081190 @default.
• W2517503832 cites W2138920974 @default.
• W2517503832 cites W2147358995 @default.
• W2517503832 cites W2149441684 @default.
• W2517503832 cites W2156934935 @default.
• W2517503832 cites W2158217645 @default.
• W2517503832 cites W2158485828 @default.
• W2517503832 cites W2199138983 @default.
• W2517503832 cites W2244015304 @default.
• W2517503832 cites W2422223356 @default.
• W2517503832 cites W4237629094 @default.
• W2517503832 doi "https://doi.org/10.1186/s13046-016-0403-2" @default.
• W2517503832 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5002170" @default.
• W2517503832 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27567667" @default.
• W2517503832 hasPublicationYear "2016" @default.
• W2517503832 type Work @default.
• W2517503832 sameAs 2517503832 @default.
• W2517503832 citedByCount "33" @default.
• W2517503832 countsByYear W25175038322017 @default.
• W2517503832 countsByYear W25175038322018 @default.
• W2517503832 countsByYear W25175038322019 @default.
• W2517503832 countsByYear W25175038322020 @default.
• W2517503832 countsByYear W25175038322021 @default.
• W2517503832 countsByYear W25175038322022 @default.
• W2517503832 countsByYear W25175038322023 @default.
• W2517503832 crossrefType "journal-article" @default.
• W2517503832 hasAuthorship W2517503832A5009697908 @default.
• W2517503832 hasAuthorship W2517503832A5012748027 @default.
• W2517503832 hasAuthorship W2517503832A5016282780 @default.
• W2517503832 hasAuthorship W2517503832A5023103876 @default.
• W2517503832 hasAuthorship W2517503832A5034266315 @default.
• W2517503832 hasAuthorship W2517503832A5042453706 @default.
• W2517503832 hasAuthorship W2517503832A5053427316 @default.

• next