FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2517504297> ?p ?o ?g. }

• W2517504297 endingPage "3597" @default.
• W2517504297 startingPage "3591" @default.
• W2517504297 abstract "Survivin is one of the apoptosis-related inhibitors that is associated with a more aggressive behavior and a poor prognosis in numerous types of malignancies, including colorectal cancer (CRC). The objective of the present study was to perform immunohistochemical tissue analysis of survivin expression and serum analysis of survivin levels in CRC patients. The study group consisted of 55 CRC patients. Survivin expression was assessed by immunohistochemistry in 38 patients using monoclonal antibodies. Color reactions were observed in the nucleus and cytoplasm of the cancer cells. The expression was defined based on the H-score method. The level of survivin was determined using the enzyme-linked immunosorbent assay method. A positive immunoreaction was observed in the tumor tissues of 84.2% (32/38) of patients with CRC, consisting of nuclear (63.2%; 24/38) and cytoplasmic (81.6%; 31/38) expression. The survivin nuclear expression was associated with tumor mass location and the presence of distant metastases (P=0.048 and P=0.026, respectively). Survivin was detected in the sera of 38.2% (21/55) of CRC patients and in 81.8% (18/22) of healthy individuals. Serum protein levels were found to correlate with hematocrit (P=0.035), hemoglobin (P=0.008) and albumin (P=0.045), but not with any of the investigated clinicopathological parameters. The immunohistochemical positive reaction of survivin in the nuclei of cancer cells may condition their proliferative capacity, which is associated with higher risk of developing metastatic foci. Thus, the present study suggests that the expression of survivin may have diagnostic implications in cancer of the colon and thus requires further research. By contrast, the survivin serum level in CRC patients appears to be diagnostically ineffectual for clinical use." @default.
• W2517504297 created "2016-09-16" @default.
• W2517504297 creator A5000020921 @default.
• W2517504297 creator A5002251157 @default.
• W2517504297 creator A5050652846 @default.
• W2517504297 creator A5089281935 @default.
• W2517504297 creator A5091619787 @default.
• W2517504297 date "2016-09-01" @default.
• W2517504297 modified "2023-10-16" @default.
• W2517504297 title "Immunohistochemical expression and serum level of survivin protein in colorectal cancer patients" @default.
• W2517504297 cites W1549487237 @default.
• W2517504297 cites W1757111527 @default.
• W2517504297 cites W1964165239 @default.
• W2517504297 cites W1976890165 @default.
• W2517504297 cites W1977147979 @default.
• W2517504297 cites W1981989535 @default.
• W2517504297 cites W1998073543 @default.
• W2517504297 cites W2013501682 @default.
• W2517504297 cites W2020333634 @default.
• W2517504297 cites W2035523654 @default.
• W2517504297 cites W2045796964 @default.
• W2517504297 cites W2058615464 @default.
• W2517504297 cites W2084495964 @default.
• W2517504297 cites W2092735347 @default.
• W2517504297 cites W2111789143 @default.
• W2517504297 cites W2117692326 @default.
• W2517504297 cites W2124785173 @default.
• W2517504297 cites W2131563286 @default.
• W2517504297 cites W2142614342 @default.
• W2517504297 cites W2143209174 @default.
• W2517504297 cites W2145941511 @default.
• W2517504297 cites W2150027485 @default.
• W2517504297 cites W2151559423 @default.
• W2517504297 cites W2160330814 @default.
• W2517504297 cites W2163755403 @default.
• W2517504297 cites W2165234400 @default.
• W2517504297 cites W2169293095 @default.
• W2517504297 cites W2399462535 @default.
• W2517504297 cites W4236504362 @default.
• W2517504297 cites W4249233937 @default.
• W2517504297 cites W52745064 @default.
• W2517504297 cites W137220887 @default.
• W2517504297 cites W2097849581 @default.
• W2517504297 doi "https://doi.org/10.3892/ol.2016.5075" @default.
• W2517504297 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5104054" @default.
• W2517504297 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27900041" @default.
• W2517504297 hasPublicationYear "2016" @default.
• W2517504297 type Work @default.
• W2517504297 sameAs 2517504297 @default.
• W2517504297 citedByCount "16" @default.
• W2517504297 countsByYear W25175042972018 @default.
• W2517504297 countsByYear W25175042972019 @default.
• W2517504297 countsByYear W25175042972020 @default.
• W2517504297 countsByYear W25175042972021 @default.
• W2517504297 countsByYear W25175042972022 @default.
• W2517504297 countsByYear W25175042972023 @default.
• W2517504297 crossrefType "journal-article" @default.
• W2517504297 hasAuthorship W2517504297A5000020921 @default.
• W2517504297 hasAuthorship W2517504297A5002251157 @default.
• W2517504297 hasAuthorship W2517504297A5050652846 @default.
• W2517504297 hasAuthorship W2517504297A5089281935 @default.
• W2517504297 hasAuthorship W2517504297A5091619787 @default.
• W2517504297 hasBestOaLocation W25175042971 @default.
• W2517504297 hasConcept C121608353 @default.
• W2517504297 hasConcept C126322002 @default.
• W2517504297 hasConcept C142724271 @default.
• W2517504297 hasConcept C143998085 @default.
• W2517504297 hasConcept C204232928 @default.
• W2517504297 hasConcept C2775975398 @default.
• W2517504297 hasConcept C2781018059 @default.
• W2517504297 hasConcept C29537977 @default.
• W2517504297 hasConcept C502942594 @default.
• W2517504297 hasConcept C526805850 @default.
• W2517504297 hasConcept C67082663 @default.
• W2517504297 hasConcept C71924100 @default.
• W2517504297 hasConceptScore W2517504297C121608353 @default.
• W2517504297 hasConceptScore W2517504297C126322002 @default.
• W2517504297 hasConceptScore W2517504297C142724271 @default.
• W2517504297 hasConceptScore W2517504297C143998085 @default.
• W2517504297 hasConceptScore W2517504297C204232928 @default.
• W2517504297 hasConceptScore W2517504297C2775975398 @default.
• W2517504297 hasConceptScore W2517504297C2781018059 @default.
• W2517504297 hasConceptScore W2517504297C29537977 @default.
• W2517504297 hasConceptScore W2517504297C502942594 @default.
• W2517504297 hasConceptScore W2517504297C526805850 @default.
• W2517504297 hasConceptScore W2517504297C67082663 @default.
• W2517504297 hasConceptScore W2517504297C71924100 @default.
• W2517504297 hasIssue "5" @default.
• W2517504297 hasLocation W25175042971 @default.
• W2517504297 hasLocation W25175042972 @default.
• W2517504297 hasLocation W25175042973 @default.
• W2517504297 hasLocation W25175042974 @default.
• W2517504297 hasOpenAccess W2517504297 @default.
• W2517504297 hasPrimaryLocation W25175042971 @default.
• W2517504297 hasRelatedWork W1990949341 @default.
• W2517504297 hasRelatedWork W2106872445 @default.
• W2517504297 hasRelatedWork W2120086268 @default.
• W2517504297 hasRelatedWork W2148971136 @default.

• next