FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W25175084> ?p ?o ?g. }

• W25175084 endingPage "65" @default.
• W25175084 startingPage "55" @default.
• W25175084 abstract "Double-strand breaks (DSBs) represent major threats in chromosomal DNA. They arise either as intermediate structures during recombination, replication and repair events or as potentially lethal lesions introduced by ionising radiation or drugs. In any case, DSBs have to be eliminated immediately, because of the recombinogenic capacity of the DNA ends generated by the DSB that increases the risk for undesired chromosomal aberrations (CAs). In order to cope with DSBs, cells exhibit two different sets of repair activities, namely non-homlogous end joining (NHEJ) and homologous recombinational repair (HRR). Both pathways are regulated during the cell cycle with peak activities either in G1 phase (NHEJ) or in late S and G2 phases (HRR). While NHEJ has the capacity to join arbitrary DNA ends together, HRR depends on the presence of a second undamaged sequence in the genome providing a template for the reconstitution of the sequence at the DSB site. While most of the proteins identified so far participate in one of the two repair pathways, a few proteins are known to participate in both pathways. These last group of proteins is supposed to be involved in the selection process of the DNA repair pathway. Mutations in one DSB repair system result in the accumulation of DSBs and increased levels of CAs. As a result, genome instability is observed in cells with impaired DSB repair functions." @default.
• W25175084 created "2016-06-24" @default.
• W25175084 creator A5062875789 @default.
• W25175084 date "2007-05-31" @default.
• W25175084 modified "2023-09-24" @default.
• W25175084 title "Double Strand Break Repair Mechanisms in Mammalian Cells" @default.
• W25175084 cites W1964882397 @default.
• W25175084 cites W1977001542 @default.
• W25175084 cites W1981372238 @default.
• W25175084 cites W1986262530 @default.
• W25175084 cites W1986320226 @default.
• W25175084 cites W1986802053 @default.
• W25175084 cites W1999064296 @default.
• W25175084 cites W2001341440 @default.
• W25175084 cites W2003239553 @default.
• W25175084 cites W2005284058 @default.
• W25175084 cites W2009721257 @default.
• W25175084 cites W2010659234 @default.
• W25175084 cites W2012071848 @default.
• W25175084 cites W2025015409 @default.
• W25175084 cites W2034252391 @default.
• W25175084 cites W2043990544 @default.
• W25175084 cites W2050821897 @default.
• W25175084 cites W2053311488 @default.
• W25175084 cites W2065872558 @default.
• W25175084 cites W2067982379 @default.
• W25175084 cites W2068206902 @default.
• W25175084 cites W2073005211 @default.
• W25175084 cites W2076720368 @default.
• W25175084 cites W2087565131 @default.
• W25175084 cites W2099627146 @default.
• W25175084 cites W2102570250 @default.
• W25175084 cites W2108742137 @default.
• W25175084 cites W2117502397 @default.
• W25175084 cites W2120486350 @default.
• W25175084 cites W2122922362 @default.
• W25175084 cites W2124037827 @default.
• W25175084 cites W2127141477 @default.
• W25175084 cites W2135418033 @default.
• W25175084 cites W2144550200 @default.
• W25175084 cites W2146176862 @default.
• W25175084 cites W2156645202 @default.
• W25175084 cites W2159825246 @default.
• W25175084 cites W2416999392 @default.
• W25175084 cites W2087505473 @default.
• W25175084 doi "https://doi.org/10.1007/978-3-540-71414-9_4" @default.
• W25175084 hasPublicationYear "2007" @default.
• W25175084 type Work @default.
• W25175084 sameAs 25175084 @default.
• W25175084 citedByCount "1" @default.
• W25175084 crossrefType "book-chapter" @default.
• W25175084 hasAuthorship W25175084A5062875789 @default.
• W25175084 hasBestOaLocation W251750841 @default.
• W25175084 hasConcept C102744134 @default.
• W25175084 hasConcept C104317684 @default.
• W25175084 hasConcept C104451858 @default.
• W25175084 hasConcept C113271649 @default.
• W25175084 hasConcept C122917832 @default.
• W25175084 hasConcept C134935766 @default.
• W25175084 hasConcept C141231307 @default.
• W25175084 hasConcept C143425029 @default.
• W25175084 hasConcept C145803527 @default.
• W25175084 hasConcept C1491633281 @default.
• W25175084 hasConcept C153911025 @default.
• W25175084 hasConcept C178169997 @default.
• W25175084 hasConcept C29537977 @default.
• W25175084 hasConcept C54355233 @default.
• W25175084 hasConcept C552990157 @default.
• W25175084 hasConcept C73573662 @default.
• W25175084 hasConcept C74054111 @default.
• W25175084 hasConcept C86339819 @default.
• W25175084 hasConcept C86803240 @default.
• W25175084 hasConcept C94966510 @default.
• W25175084 hasConcept C95444343 @default.
• W25175084 hasConceptScore W25175084C102744134 @default.
• W25175084 hasConceptScore W25175084C104317684 @default.
• W25175084 hasConceptScore W25175084C104451858 @default.
• W25175084 hasConceptScore W25175084C113271649 @default.
• W25175084 hasConceptScore W25175084C122917832 @default.
• W25175084 hasConceptScore W25175084C134935766 @default.
• W25175084 hasConceptScore W25175084C141231307 @default.
• W25175084 hasConceptScore W25175084C143425029 @default.
• W25175084 hasConceptScore W25175084C145803527 @default.
• W25175084 hasConceptScore W25175084C1491633281 @default.
• W25175084 hasConceptScore W25175084C153911025 @default.
• W25175084 hasConceptScore W25175084C178169997 @default.
• W25175084 hasConceptScore W25175084C29537977 @default.
• W25175084 hasConceptScore W25175084C54355233 @default.
• W25175084 hasConceptScore W25175084C552990157 @default.
• W25175084 hasConceptScore W25175084C73573662 @default.
• W25175084 hasConceptScore W25175084C74054111 @default.
• W25175084 hasConceptScore W25175084C86339819 @default.
• W25175084 hasConceptScore W25175084C86803240 @default.
• W25175084 hasConceptScore W25175084C94966510 @default.
• W25175084 hasConceptScore W25175084C95444343 @default.
• W25175084 hasLocation W251750841 @default.
• W25175084 hasOpenAccess W25175084 @default.
• W25175084 hasPrimaryLocation W251750841 @default.

• next