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• W2517586180 abstract "While the accuracy of patient setup itself has been well documented in stereotactic radiosurgery (SRS), the amount of rotational patient setup errors needed to impact this accuracy is not well defined. The purpose of this study is to explore potential rotational setup error thresholds for SRS treatments of brain metastases. Two groups were analyzed in this study: Group A consisted of twenty cases where a single brain metastasis treatment was planned using a single isocenter located within the tumor; Group B consisted of five cases where two brain metastases were planned using a single isocenter located between the tumors. All twenty-five cases underwent simulations for rotations around the treatment isocenter of ±1°, ±3°, ±5°, and ±7°. In addition, cases in Group B included simulations of ±0.5° and ±2°. The percent of the gross target volume (GTV) and planning target volume (PTV) that received the prescription dose (Vp) was compared between the original plans and rotation simulations to determine what degree of rotations will cause Vp loss greater than 0% and 1% respectively. In Group A, the average loss in Vp for the GTV and PTV was 0% and below 1% respectively for rotations below ±3°. Using the Spearman correlation coefficient, Vp loss in Group A showed very weak to weak correlation with physical characteristic of the tumor. In Group B, the average loss in Vp for the GTV and PTV was 0% and below 1% respectively for rotations of ±0.5°. Vp loss as a result of rotations showed very strong correlation with increasing tumor distance from treatment isocenter. Our study suggests that a patient rotational setup error threshold of ±2° around all axes for isocentric treatments is conservative. For nonisocentric treatments, the rotational setup error threshold may need to be as low as or lower than ±0.5° for tumors that are far from the treatment isocenter." @default.
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• W2517586180 date "2016-08-23" @default.
• W2517586180 modified "2023-09-25" @default.
• W2517586180 title "Establishing a threshold for rotational patient setup errors in linear accelerator-based stereotactic radiosurgery" @default.
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• W2517586180 doi "https://doi.org/10.1088/2057-1976/2/4/045018" @default.
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