Matches in SemOpenAlex for { <https://semopenalex.org/work/W2517587462> ?p ?o ?g. }
Showing items 1 to 94 of
94
with 100 items per page.
- W2517587462 endingPage "1455" @default.
- W2517587462 startingPage "1451" @default.
- W2517587462 abstract "<h3>BACKGROUND:</h3> Continuous high-frequency oscillation (CHFO) creates a pressure gradient in the small airways that accelerates expiratory flow. The intended use of CHFO therapy is to facilitate secretion removal and treat atelectasis. Our objective was to assess the feasibility, safety, and efficacy of CHFO in the mechanically ventilated pediatric population. <h3>METHODS:</h3> After institutional review board approval, we retrospectively reviewed medical records of mechanically ventilated children treated with CHFO (the MetaNeb system) at our institution from July 1, 2007 through August 31, 2012. Patients supported with extracorporeal membrane oxygenation were excluded. We evaluated changes in ventilator settings in subjects with ventilator data documented within 6 h pre- and post-treatment. We evaluated arterial blood gas (ABG) results for individual treatments, comparing ABG results within 8 h pre-therapy to ABG results within 3 h post-treatment. Oxygen index and P<sub>aO<sub>2</sub></sub>/F<sub>IO<sub>2</sub></sub> were calculated. Demographic data, blood pressure, heart rate, and development of new air leak while being treated with CHFO were recorded. Pre- and post-CHFO measurements were compared using Wilcoxon signed-rank testing. <h3>RESULTS:</h3> Our cohort included 59 invasively ventilated subjects. Median age was 2 y (range 1 month to 19 y), and median weight was 14 kg (2–81 kg). We evaluated data on 528 total treatments (range per subject 1–39 treatments). Peak inspiratory pressure significantly decreased with CHFO, whereas other parameters, including P<sub>aCO<sub>2</sub></sub> and breathing frequency, remained stable. There was no significant change in systolic blood pressure, diastolic blood pressure, or heart rate following treatment with CHFO. One subject (2%) developed a clinically insignificant pneumothorax during CHFO. <h3>CONCLUSIONS:</h3> CHFO is feasible and seems safe in our cohort of mechanically ventilated pediatric subjects. The rate of pneumothorax was consistent with that seen in similar pediatric ICU populations. These preliminary results suggest that CHFO may be beneficial by improving lung compliance in pediatric subjects with secretion-induced atelectasis. Prospective clinical studies are needed to further evaluate the clinical efficacy and safety of CHFO in children receiving invasive mechanical ventilation." @default.
- W2517587462 created "2016-09-16" @default.
- W2517587462 creator A5009991130 @default.
- W2517587462 creator A5012994707 @default.
- W2517587462 creator A5020991645 @default.
- W2517587462 creator A5021053494 @default.
- W2517587462 creator A5037855924 @default.
- W2517587462 creator A5085031950 @default.
- W2517587462 date "2016-08-16" @default.
- W2517587462 modified "2023-10-01" @default.
- W2517587462 title "Continuous High-Frequency Oscillation Therapy in Invasively Ventilated Pediatric Subjects in the Critical Care Setting" @default.
- W2517587462 cites W1876655787 @default.
- W2517587462 cites W1880210517 @default.
- W2517587462 cites W1975501160 @default.
- W2517587462 cites W1977269716 @default.
- W2517587462 cites W1990460863 @default.
- W2517587462 cites W2007113418 @default.
- W2517587462 cites W2020565177 @default.
- W2517587462 cites W2036060010 @default.
- W2517587462 cites W2133982835 @default.
- W2517587462 cites W2150237232 @default.
- W2517587462 cites W2186497021 @default.
- W2517587462 cites W90601029 @default.
- W2517587462 cites W992313 @default.
- W2517587462 doi "https://doi.org/10.4187/respcare.04368" @default.
- W2517587462 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27530418" @default.
- W2517587462 hasPublicationYear "2016" @default.
- W2517587462 type Work @default.
- W2517587462 sameAs 2517587462 @default.
- W2517587462 citedByCount "8" @default.
- W2517587462 countsByYear W25175874622017 @default.
- W2517587462 countsByYear W25175874622018 @default.
- W2517587462 countsByYear W25175874622019 @default.
- W2517587462 countsByYear W25175874622020 @default.
- W2517587462 countsByYear W25175874622021 @default.
- W2517587462 countsByYear W25175874622022 @default.
- W2517587462 crossrefType "journal-article" @default.
- W2517587462 hasAuthorship W2517587462A5009991130 @default.
- W2517587462 hasAuthorship W2517587462A5012994707 @default.
- W2517587462 hasAuthorship W2517587462A5020991645 @default.
- W2517587462 hasAuthorship W2517587462A5021053494 @default.
- W2517587462 hasAuthorship W2517587462A5037855924 @default.
- W2517587462 hasAuthorship W2517587462A5085031950 @default.
- W2517587462 hasBestOaLocation W25175874621 @default.
- W2517587462 hasConcept C126322002 @default.
- W2517587462 hasConcept C141071460 @default.
- W2517587462 hasConcept C177713679 @default.
- W2517587462 hasConcept C2776691311 @default.
- W2517587462 hasConcept C2776858399 @default.
- W2517587462 hasConcept C2777080012 @default.
- W2517587462 hasConcept C2777714996 @default.
- W2517587462 hasConcept C2781101014 @default.
- W2517587462 hasConcept C2908647359 @default.
- W2517587462 hasConcept C2987404301 @default.
- W2517587462 hasConcept C42219234 @default.
- W2517587462 hasConcept C70289976 @default.
- W2517587462 hasConcept C71924100 @default.
- W2517587462 hasConcept C99454951 @default.
- W2517587462 hasConceptScore W2517587462C126322002 @default.
- W2517587462 hasConceptScore W2517587462C141071460 @default.
- W2517587462 hasConceptScore W2517587462C177713679 @default.
- W2517587462 hasConceptScore W2517587462C2776691311 @default.
- W2517587462 hasConceptScore W2517587462C2776858399 @default.
- W2517587462 hasConceptScore W2517587462C2777080012 @default.
- W2517587462 hasConceptScore W2517587462C2777714996 @default.
- W2517587462 hasConceptScore W2517587462C2781101014 @default.
- W2517587462 hasConceptScore W2517587462C2908647359 @default.
- W2517587462 hasConceptScore W2517587462C2987404301 @default.
- W2517587462 hasConceptScore W2517587462C42219234 @default.
- W2517587462 hasConceptScore W2517587462C70289976 @default.
- W2517587462 hasConceptScore W2517587462C71924100 @default.
- W2517587462 hasConceptScore W2517587462C99454951 @default.
- W2517587462 hasIssue "11" @default.
- W2517587462 hasLocation W25175874621 @default.
- W2517587462 hasLocation W25175874622 @default.
- W2517587462 hasOpenAccess W2517587462 @default.
- W2517587462 hasPrimaryLocation W25175874621 @default.
- W2517587462 hasRelatedWork W144797025 @default.
- W2517587462 hasRelatedWork W1983917694 @default.
- W2517587462 hasRelatedWork W2074217702 @default.
- W2517587462 hasRelatedWork W2296325480 @default.
- W2517587462 hasRelatedWork W2413564653 @default.
- W2517587462 hasRelatedWork W2466768823 @default.
- W2517587462 hasRelatedWork W2519916179 @default.
- W2517587462 hasRelatedWork W2591244723 @default.
- W2517587462 hasRelatedWork W3198698033 @default.
- W2517587462 hasRelatedWork W4302009456 @default.
- W2517587462 hasVolume "61" @default.
- W2517587462 isParatext "false" @default.
- W2517587462 isRetracted "false" @default.
- W2517587462 magId "2517587462" @default.
- W2517587462 workType "article" @default.