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- W2517731408 startingPage "e1005343" @default.
- W2517731408 abstract "Experiments show that spike-triggered stimulation performed with Bidirectional Brain-Computer-Interfaces (BBCI) can artificially strengthen connections between separate neural sites in motor cortex (MC). When spikes from a neuron recorded at one MC site trigger stimuli at a second target site after a fixed delay, the connections between sites eventually strengthen. It was also found that effective spike-stimulus delays are consistent with experimentally derived spike-timing-dependent plasticity (STDP) rules, suggesting that STDP is key to drive these changes. However, the impact of STDP at the level of circuits, and the mechanisms governing its modification with neural implants remain poorly understood. The present work describes a recurrent neural network model with probabilistic spiking mechanisms and plastic synapses capable of capturing both neural and synaptic activity statistics relevant to BBCI conditioning protocols. Our model successfully reproduces key experimental results, both established and new, and offers mechanistic insights into spike-triggered conditioning. Using analytical calculations and numerical simulations, we derive optimal operational regimes for BBCIs, and formulate predictions concerning the efficacy of spike-triggered conditioning in different regimes of cortical activity." @default.
- W2517731408 created "2016-09-16" @default.
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- W2517731408 date "2017-02-02" @default.
- W2517731408 modified "2023-10-13" @default.
- W2517731408 title "Correlation-based model of artificially induced plasticity in motor cortex by a bidirectional brain-computer interface" @default.
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- W2517731408 doi "https://doi.org/10.1371/journal.pcbi.1005343" @default.
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