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• W2517751539 startingPage "1012" @default.
• W2517751539 abstract "The hypothesis of atherosclerosis as an inflammatory process has been a leitmotiv in cardiology for the past 20 years, and has now led to the launch of clinical trials aimed at testing whether drugs that primarily target inflammation can reduce cardiovascular events. Inflammation indeed drives all phases of atherosclerosis, from inception, through progression, and ultimately acute thrombotic complications (plaque rupture and probably plaque erosion). Since plaque rupture and erosion cause most acute coronary syndromes, appropriately tuned anti-inflammatory treatments should limit myocardial infarction and cardiovascular death. Beyond interrupting inflammation-related plaque disruption, such treatments might, however, also ameliorate the propensity to thrombosis once the trigger (plaque rupture or erosion) has occurred. Several lines of evidence support this view: experimental data document the role of inflammation in platelet activation, tissue factor-mediated coagulation, hyperfibrinogenaemia, impaired activity of natural anticoagulants (including those expressed by endothelial cells), and reduced fibrinolytic activity. Supporting evidence also derives from the involvement of inflammation in venous thrombosis, a process that commonly occurs in the absence of traditional risk factors for atherosclerosis but is associated with several inflammatory diseases including obesity. Ongoing trials, in addition to evaluating effects on primary outcomes, will afford the opportunity to probe the possibility that anti-inflammatory interventions that yield salutary changes in biomarkers of the thrombotic/fibrinolytic balance also translate into reduction of clinical events." @default.
• W2517751539 created "2016-09-16" @default.
• W2517751539 creator A5001863713 @default.
• W2517751539 creator A5043201732 @default.
• W2517751539 creator A5067302152 @default.
• W2517751539 date "2016-11-01" @default.
• W2517751539 modified "2023-10-10" @default.
• W2517751539 title "Inflammation and thrombosis – testing the hypothesis with anti- inflammatory drug trials" @default.
• W2517751539 cites W116933141 @default.
• W2517751539 cites W146872388 @default.
• W2517751539 cites W1489090304 @default.
• W2517751539 cites W1553985728 @default.
• W2517751539 cites W1558766638 @default.
• W2517751539 cites W1593008417 @default.
• W2517751539 cites W166112863 @default.
• W2517751539 cites W1840986526 @default.
• W2517751539 cites W1925096404 @default.
• W2517751539 cites W1959701674 @default.
• W2517751539 cites W1972483153 @default.
• W2517751539 cites W1975968199 @default.
• W2517751539 cites W1976129489 @default.
• W2517751539 cites W1985554823 @default.
• W2517751539 cites W2008960002 @default.
• W2517751539 cites W2010132585 @default.
• W2517751539 cites W2010352517 @default.
• W2517751539 cites W2010867960 @default.
• W2517751539 cites W2015639803 @default.
• W2517751539 cites W2024761692 @default.
• W2517751539 cites W2024773717 @default.
• W2517751539 cites W2025119523 @default.
• W2517751539 cites W2029613484 @default.
• W2517751539 cites W2029884260 @default.
• W2517751539 cites W2031583285 @default.
• W2517751539 cites W2045819100 @default.
• W2517751539 cites W2049749101 @default.
• W2517751539 cites W2053634523 @default.
• W2517751539 cites W2056844042 @default.
• W2517751539 cites W2057654013 @default.
• W2517751539 cites W2058842531 @default.
• W2517751539 cites W2064369146 @default.
• W2517751539 cites W2066963386 @default.
• W2517751539 cites W2071181759 @default.
• W2517751539 cites W2072339607 @default.
• W2517751539 cites W2072453475 @default.
• W2517751539 cites W2073054137 @default.
• W2517751539 cites W2074115529 @default.
• W2517751539 cites W2076988382 @default.
• W2517751539 cites W2078817520 @default.
• W2517751539 cites W2090465797 @default.
• W2517751539 cites W2092707717 @default.
• W2517751539 cites W2093529862 @default.
• W2517751539 cites W2095277844 @default.
• W2517751539 cites W2095377565 @default.
• W2517751539 cites W2099224777 @default.
• W2517751539 cites W2103339073 @default.
• W2517751539 cites W2113978145 @default.
• W2517751539 cites W2116209993 @default.
• W2517751539 cites W2118154631 @default.
• W2517751539 cites W2118869024 @default.
• W2517751539 cites W2119394245 @default.
• W2517751539 cites W2123566103 @default.
• W2517751539 cites W2124551895 @default.
• W2517751539 cites W2125412499 @default.
• W2517751539 cites W2126384096 @default.
• W2517751539 cites W2128611300 @default.
• W2517751539 cites W2129598732 @default.
• W2517751539 cites W2131525958 @default.
• W2517751539 cites W2132064529 @default.
• W2517751539 cites W2133872135 @default.
• W2517751539 cites W2138566208 @default.
• W2517751539 cites W2139957955 @default.
• W2517751539 cites W2150100875 @default.
• W2517751539 cites W2151247869 @default.
• W2517751539 cites W2152143425 @default.
• W2517751539 cites W2152502508 @default.
• W2517751539 cites W2154036638 @default.
• W2517751539 cites W2160613916 @default.
• W2517751539 cites W2161735825 @default.
• W2517751539 cites W2163331533 @default.
• W2517751539 cites W2166646911 @default.
• W2517751539 cites W2166854766 @default.
• W2517751539 cites W2172191543 @default.
• W2517751539 cites W2276329456 @default.
• W2517751539 cites W2285780972 @default.
• W2517751539 cites W2312972812 @default.
• W2517751539 cites W2316243284 @default.
• W2517751539 cites W2316376271 @default.
• W2517751539 cites W2334118820 @default.
• W2517751539 cites W2337488815 @default.
• W2517751539 cites W2342188548 @default.
• W2517751539 cites W2342473733 @default.
• W2517751539 cites W2349457619 @default.
• W2517751539 cites W2396184234 @default.
• W2517751539 cites W2408538721 @default.
• W2517751539 cites W4211168907 @default.
• W2517751539 cites W4213319115 @default.
• W2517751539 cites W581266853 @default.
• W2517751539 cites W82493482 @default.

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