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• W2517804568 abstract "To compare the number of metaphase 2 (M2) oocytes vitrified following GnRH agonist (GnRHa) or hCG priming, 36h before oocyte retrieval, in cancer patients undergoing IVM for urgent FP. Prospective study. From January 2009 to April 2015, we prospectively studied 373 patients, aged 18-41 years and candidates for FP with IVM of oocytes followed by oocyte or embryo cryopreservation. All patients met the following inclusion criteria: two ovaries visible and easily accessible to ultrasound-guided puncture and antral follicle count (AFC) > 8. Exclusion criteria were previous history of chemotherapy and polycystic ovarian syndrome (PCOS). Priming was achieved with either GnRHa (triptorelin 0.2 mg, SC, n=235) or hCG (recombinant hCG, 250 μg, SC, n=138). Patients in the hCG and the GnRHa groups were comparable in terms of age (32.2±4.9 vs 31.7±4.4 years, respectively, NS), body mass index (22.8±3.9 vs 23.2±4.3 Kg/m2, respectively, NS) and ovarian reserve tests (AFC: 18.6±8.0 vs 18.8±7.6 follicles, respectively, NS; serum Anti-Mullerian Hormone (AMH) levels: 3.6±2.7 vs 3.6±2.4 ng/mL, respectively, NS). The number of immature oocytes retrieved was significantly higher in the GnRHa group compared to hCG group (9.1±6.8 vs 7.7±5.5 oocytes, respectively, p = 0.04) but the maturation rate after 48h was statistically similar (59±31 vs 64±26 %, respectively, p=0.07). Finally, the total number of vitrified M2 oocytes was comparable between the two groups (5.2±4.2 vs 4.9±4.0, respectively, p=0.6). Priming with administration of hCG has been shown to improve outcomes of IVM cycles in PCOS infertile women. In addition, it has been suggested that a mild stimulation with FSH before hCG priming could further increase the oocyte yield. However, this double priming is not always feasible in cancer patients undergoing urgent FP with IVM. GnRHa offer the advantage of stimulating a combined endogenous FSH and LH surge in a single injection. Our study showed that GnRHa priming leads to similar outcomes than hCG in IVM cycles for urgent FP. Randomized control trials are needed to objectively assess the need for priming in normo-ovulatory cancer patients, and the best way to provide it if required." @default.
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• W2517804568 date "2016-09-01" @default.
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• W2517804568 title "Comparison of GnRH agonist and hCG for priming in vitro maturation (IVM) cycles in cancer patients undergoing urgent fertility preservation (FP)" @default.
• W2517804568 doi "https://doi.org/10.1016/j.fertnstert.2016.07.393" @default.
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