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- W2517963434 abstract "While percutaneous transluminal coronary intervention has revolutionized the management of patients with coronary artery disease, this technological advance is neither innocuous nor a panacea. In addition to the technical limitations of the procedure, it is now well recognized that serious vascular injury is caused by the treatment device that creates a perfect milieu for coronary thrombosis (1–3). Clinical trials of the monoclonal antibody abciximab (c7E3 Fab; ReoProTM, Eli Lilly and Company [Indianapolis, IN]/Centocor [Malvern, PA]) directed at the platelet glycoprotein (GP) lib/Illa integrin have clearly documented that inhibition of this receptor during coronary intervention reduces thrombotic complications and improves clinical outcomes (4–8). These positive clinical trial results, coupled with a clearer understanding of platelet physiology, have stimulated the search and encouraged the development of other parenteral inhibitors of the GP IIb/IIIa receptor." @default.
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- W2517963434 date "1999-01-01" @default.
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- W2517963434 title "Eptifibatide in Coronary Intervention—The IMPACT Trials" @default.
- W2517963434 doi "https://doi.org/10.1007/978-1-59259-724-6_6" @default.
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