Matches in SemOpenAlex for { <https://semopenalex.org/work/W2518040215> ?p ?o ?g. }
Showing items 1 to 73 of
73
with 100 items per page.
- W2518040215 endingPage "90" @default.
- W2518040215 startingPage "1086" @default.
- W2518040215 abstract "Objective：To explore the influence of co-inhibiting mTORC2 and HSP90 on the proliferation and apoptosis of multiple myeloma(MM) cell line U266.During culture, the human MM cell line U266 were treated with 20 nmol/L of rapamycin, 600 nmol/L 17-AAG, 20 nmol/L of rapamycin + 600 nmol/L 17-AGG and phosphate-buffered saline (PBS), then the growth inhibition rate, morphologic changes, apoptosis rate and the expression of caspase 3 and ATK protein in U266 cells were compared and analyzed.The rapamycin and 17-AAG both could inhibit the growth of U266 cells, while the inhibitory effect of rapamycin in combination with 17-AAG on growth of U266 cells was significantly higher them that of rapamycin and 17-AAG alone and control (PBS); the apoptosis rate of U266 cells treated with rapamycin, 17-AAG and their combination was higher than that of control PBS groups, and the efficacy of 2 drug conbination was higher than that of control PBS group, and the efficacy of 2 drug combination was superior to single drug. The expression levels of caspase 3 and ATK in U266 cells treated with rapamycin, 17-AAG and their combination were higher and lower than those in control group respectively, and the efficacy of 2 drug combination was superior to signle drug. There were significant difference between them (P<0.05).The co-inhibition of mTORC2 and HSP90 can suppress the proliferation and induce the apoptosis of MM cells." @default.
- W2518040215 created "2016-09-16" @default.
- W2518040215 creator A5009669628 @default.
- W2518040215 creator A5012574212 @default.
- W2518040215 creator A5021963549 @default.
- W2518040215 creator A5028012876 @default.
- W2518040215 creator A5030376340 @default.
- W2518040215 creator A5034785395 @default.
- W2518040215 creator A5042891271 @default.
- W2518040215 creator A5064023466 @default.
- W2518040215 creator A5068553713 @default.
- W2518040215 creator A5085918263 @default.
- W2518040215 date "2016-08-01" @default.
- W2518040215 modified "2023-09-26" @default.
- W2518040215 title "[Influence of Co-inhibiting mTORC2 and HSP90 on Proliferation Apoptosis of Multiple Myeloma Cells]." @default.
- W2518040215 doi "https://doi.org/10.7534/j.issn.1009-2137.2016.04.023" @default.
- W2518040215 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27531779" @default.
- W2518040215 hasPublicationYear "2016" @default.
- W2518040215 type Work @default.
- W2518040215 sameAs 2518040215 @default.
- W2518040215 citedByCount "0" @default.
- W2518040215 crossrefType "journal-article" @default.
- W2518040215 hasAuthorship W2518040215A5009669628 @default.
- W2518040215 hasAuthorship W2518040215A5012574212 @default.
- W2518040215 hasAuthorship W2518040215A5021963549 @default.
- W2518040215 hasAuthorship W2518040215A5028012876 @default.
- W2518040215 hasAuthorship W2518040215A5030376340 @default.
- W2518040215 hasAuthorship W2518040215A5034785395 @default.
- W2518040215 hasAuthorship W2518040215A5042891271 @default.
- W2518040215 hasAuthorship W2518040215A5064023466 @default.
- W2518040215 hasAuthorship W2518040215A5068553713 @default.
- W2518040215 hasAuthorship W2518040215A5085918263 @default.
- W2518040215 hasConcept C190283241 @default.
- W2518040215 hasConcept C2779707156 @default.
- W2518040215 hasConcept C502942594 @default.
- W2518040215 hasConcept C54355233 @default.
- W2518040215 hasConcept C55493867 @default.
- W2518040215 hasConcept C62112901 @default.
- W2518040215 hasConcept C81885089 @default.
- W2518040215 hasConcept C86803240 @default.
- W2518040215 hasConcept C95444343 @default.
- W2518040215 hasConcept C98274493 @default.
- W2518040215 hasConceptScore W2518040215C190283241 @default.
- W2518040215 hasConceptScore W2518040215C2779707156 @default.
- W2518040215 hasConceptScore W2518040215C502942594 @default.
- W2518040215 hasConceptScore W2518040215C54355233 @default.
- W2518040215 hasConceptScore W2518040215C55493867 @default.
- W2518040215 hasConceptScore W2518040215C62112901 @default.
- W2518040215 hasConceptScore W2518040215C81885089 @default.
- W2518040215 hasConceptScore W2518040215C86803240 @default.
- W2518040215 hasConceptScore W2518040215C95444343 @default.
- W2518040215 hasConceptScore W2518040215C98274493 @default.
- W2518040215 hasIssue "4" @default.
- W2518040215 hasLocation W25180402151 @default.
- W2518040215 hasOpenAccess W2518040215 @default.
- W2518040215 hasPrimaryLocation W25180402151 @default.
- W2518040215 hasRelatedWork W2070291783 @default.
- W2518040215 hasRelatedWork W2107855445 @default.
- W2518040215 hasRelatedWork W2352505828 @default.
- W2518040215 hasRelatedWork W2354718223 @default.
- W2518040215 hasRelatedWork W2358073269 @default.
- W2518040215 hasRelatedWork W2363844476 @default.
- W2518040215 hasRelatedWork W2372398475 @default.
- W2518040215 hasRelatedWork W2377991732 @default.
- W2518040215 hasRelatedWork W2381619202 @default.
- W2518040215 hasRelatedWork W3183408539 @default.
- W2518040215 hasVolume "24" @default.
- W2518040215 isParatext "false" @default.
- W2518040215 isRetracted "false" @default.
- W2518040215 magId "2518040215" @default.
- W2518040215 workType "article" @default.