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- W2518186768 endingPage "231" @default.
- W2518186768 startingPage "207" @default.
- W2518186768 abstract "Before being absorbed in the small intestine and/or colon, orally administered drugs inevitably need to pass through the stomach. Hence, it seems reasonable that the residence of a dosage form in the gastric environment, however brief it may be, may influence drug disposition further down the gastrointestinal tract and may potentially impact systemic exposure to a drug of interest. However, research efforts in the past mainly focused on drug disposition at the level of the intestine, i.e. the main site of absorption, hereby disregarding or oversimplifying the stomach's contribution to gastrointestinal drug disposition. In the first part of this review, the complexity of the stomach with regard to anatomy, physiology and gastric fluid composition is emphasized. Between-population differences in gastric functioning and physicochemical characteristics of gastric fluids are discussed. The second part of this review focuses on several of the processes to which a dosage form can be exposed during its passage through the stomach and the implications for gastrointestinal drug behaviour and systemic drug disposition. Finally, the influence of real-life dosing conditions on drug disposition is discussed in the context of the stomach." @default.
- W2518186768 created "2016-09-16" @default.
- W2518186768 creator A5000206935 @default.
- W2518186768 creator A5001257020 @default.
- W2518186768 creator A5052752998 @default.
- W2518186768 creator A5083389734 @default.
- W2518186768 date "2017-01-01" @default.
- W2518186768 modified "2023-10-12" @default.
- W2518186768 title "The dynamic gastric environment and its impact on drug and formulation behaviour" @default.
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