Matches in SemOpenAlex for { <https://semopenalex.org/work/W2518219785> ?p ?o ?g. }
- W2518219785 endingPage "21" @default.
- W2518219785 startingPage "14" @default.
- W2518219785 abstract "Originally described by the late evolutionary biologist Leigh Van Valen, the Red Queen hypothesis posits that the evolutionary arms race between hosts and their pathogens selects for discrete, genetically encoded events that lead to competitive advantages over the other species. Examples of immune evasion strategies are seen throughout the co-evolution of the mammalian immune system and pathogens, such as the enzymatic inactivation of nuclear factor-κB signaling or host translation by pathogen-encoded virulence factors. Such immunoevasive maneuvers would be expected to select for the evolution of innate immune counterstrategies. Recent advances in our understanding of host immunity and microbial pathogenesis have provided insight into a particular innate immune adaptation, termed bystander activation. Bystander activation occurs as a consequence of infected cells alerting and instructing neighboring uninfected cells to produce inflammatory mediators, either through direct cell contact or paracrine signals. Thus, bystander activation can allow the immune system to overcome the ability of pathogens to disarm immune signaling in directly infected cells. This review presents an overview of the general hallmarks of bystander activation and their emerging role in innate immunity to intracellular pathogens, as well as examples of recent mechanistic discoveries relating to the bystander activation during infection with specific pathogens relevant to human health and disease." @default.
- W2518219785 created "2016-09-16" @default.
- W2518219785 creator A5016591105 @default.
- W2518219785 creator A5050644860 @default.
- W2518219785 creator A5059475430 @default.
- W2518219785 date "2016-08-22" @default.
- W2518219785 modified "2023-10-18" @default.
- W2518219785 title "Outrunning the Red Queen: bystander activation as a means of outpacing innate immune subversion by intracellular pathogens" @default.
- W2518219785 cites W1486509539 @default.
- W2518219785 cites W1489360290 @default.
- W2518219785 cites W1496641192 @default.
- W2518219785 cites W1576621433 @default.
- W2518219785 cites W1653521872 @default.
- W2518219785 cites W1747289823 @default.
- W2518219785 cites W1821774298 @default.
- W2518219785 cites W1897605380 @default.
- W2518219785 cites W1933048492 @default.
- W2518219785 cites W1966495986 @default.
- W2518219785 cites W1966615097 @default.
- W2518219785 cites W1968134126 @default.
- W2518219785 cites W1968777463 @default.
- W2518219785 cites W1973757265 @default.
- W2518219785 cites W1978525119 @default.
- W2518219785 cites W1980190751 @default.
- W2518219785 cites W1980923315 @default.
- W2518219785 cites W1989129419 @default.
- W2518219785 cites W1996649087 @default.
- W2518219785 cites W1997001575 @default.
- W2518219785 cites W1997571827 @default.
- W2518219785 cites W2013420333 @default.
- W2518219785 cites W2018122290 @default.
- W2518219785 cites W2022273251 @default.
- W2518219785 cites W2023974021 @default.
- W2518219785 cites W2028465756 @default.
- W2518219785 cites W2032370476 @default.
- W2518219785 cites W2032958179 @default.
- W2518219785 cites W2033098156 @default.
- W2518219785 cites W2035396878 @default.
- W2518219785 cites W2039390702 @default.
- W2518219785 cites W2041345682 @default.
- W2518219785 cites W2042366210 @default.
- W2518219785 cites W2044757050 @default.
- W2518219785 cites W2045506129 @default.
- W2518219785 cites W2048765000 @default.
- W2518219785 cites W2050383810 @default.
- W2518219785 cites W2055128358 @default.
- W2518219785 cites W2059804687 @default.
- W2518219785 cites W2066586758 @default.
- W2518219785 cites W2072109464 @default.
- W2518219785 cites W2076294822 @default.
- W2518219785 cites W2082538292 @default.
- W2518219785 cites W2086764655 @default.
- W2518219785 cites W2087661745 @default.
- W2518219785 cites W2088545939 @default.
- W2518219785 cites W2089228242 @default.
- W2518219785 cites W2089503694 @default.
- W2518219785 cites W2093579074 @default.
- W2518219785 cites W2099610218 @default.
- W2518219785 cites W2102164310 @default.
- W2518219785 cites W2104276267 @default.
- W2518219785 cites W2124081239 @default.
- W2518219785 cites W2127654332 @default.
- W2518219785 cites W2133815101 @default.
- W2518219785 cites W2135783899 @default.
- W2518219785 cites W2139832462 @default.
- W2518219785 cites W2140258573 @default.
- W2518219785 cites W2142992860 @default.
- W2518219785 cites W2143119237 @default.
- W2518219785 cites W2146546101 @default.
- W2518219785 cites W2147701649 @default.
- W2518219785 cites W2147727360 @default.
- W2518219785 cites W2152347367 @default.
- W2518219785 cites W2155578687 @default.
- W2518219785 cites W2158049453 @default.
- W2518219785 cites W2161638634 @default.
- W2518219785 cites W2167381616 @default.
- W2518219785 cites W2168935743 @default.
- W2518219785 cites W2169289106 @default.
- W2518219785 cites W4256529798 @default.
- W2518219785 doi "https://doi.org/10.1038/cmi.2016.36" @default.
- W2518219785 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5214943" @default.
- W2518219785 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27545071" @default.
- W2518219785 hasPublicationYear "2016" @default.
- W2518219785 type Work @default.
- W2518219785 sameAs 2518219785 @default.
- W2518219785 citedByCount "20" @default.
- W2518219785 countsByYear W25182197852016 @default.
- W2518219785 countsByYear W25182197852017 @default.
- W2518219785 countsByYear W25182197852018 @default.
- W2518219785 countsByYear W25182197852020 @default.
- W2518219785 countsByYear W25182197852021 @default.
- W2518219785 countsByYear W25182197852022 @default.
- W2518219785 countsByYear W25182197852023 @default.
- W2518219785 crossrefType "journal-article" @default.
- W2518219785 hasAuthorship W2518219785A5016591105 @default.
- W2518219785 hasAuthorship W2518219785A5050644860 @default.
- W2518219785 hasAuthorship W2518219785A5059475430 @default.
- W2518219785 hasBestOaLocation W25182197851 @default.