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- W2518334202 abstract "A reverse phase ultra-high performance liquid chromatography (RP-UHPLC) method was developed and validated for the simultaneous estimation of Loteprednoletabonate (LOTE) and Gatifloxacin (GAT) in pharmaceuticaldosage form. The separation was carried on zorbax eclipse plus column C18 (4.6 × 50 mm, 1.8 μ particle size) column with mobile phase (pH 6.0 withtriethylamine) containing Acetonitrile, Methanol and 0.02M potassiumdihydrogen phosphate in the ratio of 40:30:30 v/v/v with a flow rate of 0.7 mL/min and UV detection at 272 nm. The linearity was found to be in range of 15.34-46.03 μg/mL (R 2 = 0.999) and 24.94-74.81 μg/mL (R 2 = 0.999) for GAT and LOTE respectively. The method has shown good, consistent recoveries for GAT 98.88-101.24% and LOTE 98.42 - 100.94% respectively. The method was found to be accurate, precise, specific,robust and linear for the determination of GAT and LOTE in pharmaceutical dosage form." @default.
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- W2518334202 date "2016-04-01" @default.
- W2518334202 modified "2023-10-06" @default.
- W2518334202 title "Simultaneous Estimation of Loteprednol Etabonate and Gatifloxacin in Pharmaceutical Dosage Form by UHPLC Method" @default.
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- W2518334202 doi "https://doi.org/10.9790/3008-1104018287" @default.
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