FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W2518440008> ?p ?o ?g. }

• W2518440008 abstract "The acquisition of inappropriate migratory feature is crucial for tumor metastasis. Rho-family GTPases including RhoA are molecular switches that play critical roles in regulating cell movement. We investigated the molecular mechanism underlying CD147 induced RhoA deactivation in hepatocellular carcinoma (HCC) cells. Wound-healing assay was performed to study the cell motility. Analysis of RhoA activation in living cells was conducted using RhoA biosensor. Changes in the expression of certain genes were determined by quantitative real-time PCR. The expression of proteins was evaluated by Western blot. Cytoskeleton reorganization and focal adhesion formation were observed by immunofluorescence staining. Further investigation on the correlation between CD147 and p190-B RhoGAP (p190-B) in HCC tissues was performed by immunological histological chemistry analysis. CD147 promoted cell movement and suppressed RhoA activation. p190-B, a negative regulator of RhoA activity, was upregulated by CD147 at both mRNA and protein levels. This regulatory relationship was further confirmed by analyzing the expression pattern of CD147 and p190-B in human HCC tissues. Silencing of p190-B caused the increased formation of stress fiber and focal adhesion and blunted the impact of CD147 overexpression on cell movement, indicating that the regulatory effect of CD147 on cell movement is mediated, at least partially, by p190-B. These findings indicated that p190-B, a negative regulator of RhoA, is positively regulated by CD147 and contributes to the regulation of cell movement in HCC. CD147 plays critical roles in the motility of cancer cells and may be therefore a valuable drug target for anti-cancer therapy." @default.
• W2518440008 created "2016-09-16" @default.
• W2518440008 creator A5010225963 @default.
• W2518440008 creator A5018051539 @default.
• W2518440008 creator A5022802322 @default.
• W2518440008 creator A5035195373 @default.
• W2518440008 creator A5070334057 @default.
• W2518440008 creator A5087061299 @default.
• W2518440008 date "2016-09-06" @default.
• W2518440008 modified "2023-10-12" @default.
• W2518440008 title "CD147 promotes cell motility via upregulation of p190-B RhoGAP in hepatocellular carcinoma" @default.
• W2518440008 cites W1551667737 @default.
• W2518440008 cites W1559117395 @default.
• W2518440008 cites W1974172346 @default.
• W2518440008 cites W1984491329 @default.
• W2518440008 cites W1985673045 @default.
• W2518440008 cites W1988475719 @default.
• W2518440008 cites W1990408088 @default.
• W2518440008 cites W1991911689 @default.
• W2518440008 cites W1997347624 @default.
• W2518440008 cites W2001439351 @default.
• W2518440008 cites W2014977030 @default.
• W2518440008 cites W2018357808 @default.
• W2518440008 cites W2019226300 @default.
• W2518440008 cites W2025540819 @default.
• W2518440008 cites W2029526923 @default.
• W2518440008 cites W2030262674 @default.
• W2518440008 cites W2031220858 @default.
• W2518440008 cites W2032268024 @default.
• W2518440008 cites W2043827150 @default.
• W2518440008 cites W2068505074 @default.
• W2518440008 cites W2070634808 @default.
• W2518440008 cites W2075487594 @default.
• W2518440008 cites W2089210429 @default.
• W2518440008 cites W2095221589 @default.
• W2518440008 cites W2101436740 @default.
• W2518440008 cites W2119427598 @default.
• W2518440008 cites W2146473598 @default.
• W2518440008 cites W2169242829 @default.
• W2518440008 cites W2216871881 @default.
• W2518440008 cites W4231400324 @default.
• W2518440008 doi "https://doi.org/10.1186/s12935-016-0344-z" @default.
• W2518440008 hasPubMedCentralId "https://www.ncbi.nlm.nih.gov/pmc/articles/5012051" @default.
• W2518440008 hasPubMedId "https://pubmed.ncbi.nlm.nih.gov/27601938" @default.
• W2518440008 hasPublicationYear "2016" @default.
• W2518440008 type Work @default.
• W2518440008 sameAs 2518440008 @default.
• W2518440008 citedByCount "6" @default.
• W2518440008 countsByYear W25184400082017 @default.
• W2518440008 countsByYear W25184400082018 @default.
• W2518440008 countsByYear W25184400082019 @default.
• W2518440008 countsByYear W25184400082022 @default.
• W2518440008 countsByYear W25184400082023 @default.
• W2518440008 crossrefType "journal-article" @default.
• W2518440008 hasAuthorship W2518440008A5010225963 @default.
• W2518440008 hasAuthorship W2518440008A5018051539 @default.
• W2518440008 hasAuthorship W2518440008A5022802322 @default.
• W2518440008 hasAuthorship W2518440008A5035195373 @default.
• W2518440008 hasAuthorship W2518440008A5070334057 @default.
• W2518440008 hasAuthorship W2518440008A5087061299 @default.
• W2518440008 hasBestOaLocation W25184400081 @default.
• W2518440008 hasConcept C104317684 @default.
• W2518440008 hasConcept C119056186 @default.
• W2518440008 hasConcept C127561419 @default.
• W2518440008 hasConcept C137738243 @default.
• W2518440008 hasConcept C142669718 @default.
• W2518440008 hasConcept C1491633281 @default.
• W2518440008 hasConcept C151166631 @default.
• W2518440008 hasConcept C185592680 @default.
• W2518440008 hasConcept C2777093181 @default.
• W2518440008 hasConcept C2993400109 @default.
• W2518440008 hasConcept C502942594 @default.
• W2518440008 hasConcept C55493867 @default.
• W2518440008 hasConcept C58207958 @default.
• W2518440008 hasConcept C62478195 @default.
• W2518440008 hasConcept C85789140 @default.
• W2518440008 hasConcept C86803240 @default.
• W2518440008 hasConcept C95444343 @default.
• W2518440008 hasConceptScore W2518440008C104317684 @default.
• W2518440008 hasConceptScore W2518440008C119056186 @default.
• W2518440008 hasConceptScore W2518440008C127561419 @default.
• W2518440008 hasConceptScore W2518440008C137738243 @default.
• W2518440008 hasConceptScore W2518440008C142669718 @default.
• W2518440008 hasConceptScore W2518440008C1491633281 @default.
• W2518440008 hasConceptScore W2518440008C151166631 @default.
• W2518440008 hasConceptScore W2518440008C185592680 @default.
• W2518440008 hasConceptScore W2518440008C2777093181 @default.
• W2518440008 hasConceptScore W2518440008C2993400109 @default.
• W2518440008 hasConceptScore W2518440008C502942594 @default.
• W2518440008 hasConceptScore W2518440008C55493867 @default.
• W2518440008 hasConceptScore W2518440008C58207958 @default.
• W2518440008 hasConceptScore W2518440008C62478195 @default.
• W2518440008 hasConceptScore W2518440008C85789140 @default.
• W2518440008 hasConceptScore W2518440008C86803240 @default.
• W2518440008 hasConceptScore W2518440008C95444343 @default.
• W2518440008 hasFunder F4320321001 @default.
• W2518440008 hasIssue "1" @default.
• W2518440008 hasLocation W25184400081 @default.
• W2518440008 hasLocation W25184400082 @default.
• W2518440008 hasLocation W25184400083 @default.

• next