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- W2518451436 abstract "Glioblastoma (GBM) is radioresistant tumors with an infaust prognosis. Local disease control is the main intent of treatment because of the high incidence of recurrence. Radiotherapy post surgical resection is the mainstay of the management of GBM; however, high dose treatments fail to improve survival. Major determinants of radioresistance are here reviewed. GBM is characterized by genomic heterogeneity intra- and intertumors. GBM cells can present dysregulation of genes involved in main sensors and effectors of DNA damage, DNA repair, cell cycle regulation, apoptosis, and signaling pathways. High expression of growth factor can affect response to radiation, as well as angiogenesis, hypoxia and presence of cancer stem cells can increase radioresistance. High expression of extracellular matrix degrading enzymes and of transcription factors master regulators of epithelial mesenchymal transition support invasiveness and diffuse infiltration. A good knowledge of basic radiobiology of GBM can help in finding new therapeutic targets." @default.
- W2518451436 created "2016-09-16" @default.
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- W2518451436 date "2016-01-01" @default.
- W2518451436 modified "2023-09-27" @default.
- W2518451436 title "Basic Knowledge of Glioblastoma Radiobiology" @default.
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- W2518451436 doi "https://doi.org/10.1007/978-3-319-28305-0_9" @default.
- W2518451436 hasPublicationYear "2016" @default.
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